Results 21 to 30 of about 74,867 (310)

Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR

iScience, 2023
Summary: Crystal and cryo-EM structures of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) bound with their peptide ligands have been obtained with full-length constructs, indicating that the extracellular domain (ECD) is ...
Huixia Wang, Wanhui Hu, Tiandan Xu, Ya Yuan, Dongsheng Liu, Kurt Wüthrich   +5 more
doaj   +1 more source

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Hepatic glucagon receptors expression in response to glucose, insulin, glucagon and immune challenge in grass carp (Ctenophcuyngodon idellus)

Aquaculture Reports, 2020
Since discovery, glucagon biology has remained enigmatic. Studies have shown that glucagon may have physiological effects beyond glucose regulation by binding to its receptor (Gcgr).
Chaobin Qin, Wenli Zhao, Guokun Yang, Hui Cao, Liping Yang, Xiaolin Meng, Xiao Yan, Guoxing Nie   +7 more
doaj   +1 more source

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]

, 2015
© 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC, Gribble, FM, Holt, MK, Reimann, F, Richards, JE, Trapp, S   +5 more
core   +2 more sources

Modulation of β-catenin signaling by glucagon receptor activation. [PDF]

PLoS ONE, 2012
The glucagon receptor (GCGR) is a member of the class B G protein-coupled receptor family. Activation of GCGR by glucagon leads to increased glucose production by the liver.
Jiyuan Ke, Chenghai Zhang, Kaleeckal G Harikumar, Cassandra R Zylstra-Diegel, Liren Wang, Laura E Mowry, Laurence J Miller, Bart O Williams, H Eric Xu   +8 more
doaj   +1 more source

Hypothalamically-Induced Insulin Release and its Potentiation During Oral and Intravenous Glucose Loads [PDF]

, 1984
Male Wistar rats were provided with bilateral cannulas in the lateral hypothalamic area (LHA) and cannulas in the left and right jugular vein. Freely moving rats provided in this way with cannulas were infused with transmitters in the LHA and with ...
A.B. Steffens, Bernstein, Berthoud, Berthoud, Bloom, Bloom, Daniel, De Groot, De Jong, E.C. Lotter, F. Kuipers, Frohman, Frohman, G. Flik, Henquin, Inoue, Iversen, Iversen, Kaneto, Kaneto, Kaneto, Kaneto, Karam, Matsushita, McCaleb, Moltz, P.G.M. Luiten, Robertson, Shimazu, Shimazu, Shimazu, Steffens, Steffens, Strubbe, Strubbe, Strubbe   +35 more
core   +4 more sources

Glucagon Cell Hyperplasia and Neoplasia With and Without Glucagon Receptor Mutations [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2015
CONTEXT: Glucagon cell adenomatosis (GCA) was recently recognized as a multifocal hyperplastic and neoplastic disease of the glucagon cells unrelated to multiple endocrine neoplasia type 1 and von-Hippel-Lindau disease. OBJECTIVE: The study focused on the molecular analysis of the glucagon receptor (GCGR) gene in GCA and a description of the ...
Sipos, Bence, Sperveslage, Jan, Anlauf, Martin, Hoffmeister, Maike, Henopp, Tobias, Buch, Stephan, Hampe, Jochen, Weber, Achim, Hammel, Pascal, Couvelard, Anne, Höbling, Walter, Lieb, Wolfgang, Boehm, Bernhard O, Klöppel, Günter   +13 more
openaire   +3 more sources

Glucagon-Like Peptide-1 Based Therapies: A New Horizon in Obesity Management [PDF]

Endocrinology and Metabolism
Obesity is a significant risk factor for health issues like type 2 diabetes and cardiovascular disease. It often proves resistant to traditional lifestyle interventions, prompting a need for more precise therapeutic strategies. This has led to a focus on
Jang Won Son, Soo Lim
doaj   +1 more source

New perspectives on the use of glucagon-like peptide 1 in diseases of the central nervous system

Current Issues in Pharmacy and Medical Sciences, 2023
Glucagon-like peptide 1 is a neuromodulatory peptide that regulates the carbohydrate metabolism. It can cross the blood-brain barrier, and, indeed, while mostly produced in the distal small intestine and colon, it is also synthesized in the nucleus of ...
Lupina Malgorzata, Listos Joanna
doaj   +1 more source

Modulating effects of RAMPs on signaling profiles of the glucagon receptor family

Acta Pharmaceutica Sinica B, 2022
Receptor activity-modulating proteins (RAMPs) are accessory molecules that form complexes with specific G protein-coupled receptors (GPCRs) and modulate their functions. It is established that RAMP interacts with the glucagon receptor family of GPCRs but
Lijun Shao, Yan Chen, Shikai Zhang, Zhihui Zhang, Yongbing Cao, Dehua Yang, Ming-Wei Wang   +6 more
doaj   +1 more source