Results 21 to 30 of about 45,803 (309)

Hypothalamically-Induced Insulin Release and its Potentiation During Oral and Intravenous Glucose Loads [PDF]

, 1984
Male Wistar rats were provided with bilateral cannulas in the lateral hypothalamic area (LHA) and cannulas in the left and right jugular vein. Freely moving rats provided in this way with cannulas were infused with transmitters in the LHA and with ...
Steffens, A.B., Steffens, A.B.,, Luiten, P.G.M., Kuipers, F.; id_orcid, Luiten, P.G.M.,, Flik, G., Flik, G.,, Kuipers, F.,, Kuipers, F., Lotter, E.C., Lotter, E.C.,   +10 more
core   +1 more source

Glucagon Cell Hyperplasia and Neoplasia With and Without Glucagon Receptor Mutations [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2015
CONTEXT: Glucagon cell adenomatosis (GCA) was recently recognized as a multifocal hyperplastic and neoplastic disease of the glucagon cells unrelated to multiple endocrine neoplasia type 1 and von-Hippel-Lindau disease. OBJECTIVE: The study focused on the molecular analysis of the glucagon receptor (GCGR) gene in GCA and a description of the ...
Sipos, Bence, Sperveslage, Jan, Anlauf, Martin, Hoffmeister, Maike, Henopp, Tobias, Buch, Stephan, Hampe, Jochen, Weber, Achim, Hammel, Pascal, Couvelard, Anne, Höbling, Walter, Lieb, Wolfgang, Boehm, Bernhard O, Klöppel, Günter   +13 more
openaire   +3 more sources

Glucagon-Like Peptide-1 Based Therapies: A New Horizon in Obesity Management [PDF]

Endocrinology and Metabolism
Obesity is a significant risk factor for health issues like type 2 diabetes and cardiovascular disease. It often proves resistant to traditional lifestyle interventions, prompting a need for more precise therapeutic strategies. This has led to a focus on
Jang Won Son, Soo Lim
doaj   +1 more source

Modulation of β-catenin signaling by glucagon receptor activation. [PDF]

PLoS ONE, 2012
The glucagon receptor (GCGR) is a member of the class B G protein-coupled receptor family. Activation of GCGR by glucagon leads to increased glucose production by the liver.
Jiyuan Ke, Chenghai Zhang, Kaleeckal G Harikumar, Cassandra R Zylstra-Diegel, Liren Wang, Laura E Mowry, Laurence J Miller, Bart O Williams, H Eric Xu   +8 more
doaj   +1 more source

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

Cell Reports, 2016
In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during metabolic challenges such as those associated with pregnancy or high-fat diet.
Joana Almaça, Judith Molina, Danusa Menegaz, Alexey N. Pronin, Alejandro Tamayo, Vladlen Slepak, Per-Olof Berggren, Alejandro Caicedo   +7 more
doaj   +1 more source

New perspectives on the use of glucagon-like peptide 1 in diseases of the central nervous system

Current Issues in Pharmacy and Medical Sciences, 2023
Glucagon-like peptide 1 is a neuromodulatory peptide that regulates the carbohydrate metabolism. It can cross the blood-brain barrier, and, indeed, while mostly produced in the distal small intestine and colon, it is also synthesized in the nucleus of ...
Lupina Malgorzata, Listos Joanna
doaj   +1 more source

Betacellulin-Induced α-Cell Proliferation Is Mediated by ErbB3 and ErbB4, and May Contribute to β-Cell Regeneration

Frontiers in Cell and Developmental Biology, 2021
Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells.
Young-Sun Lee, Young-Sun Lee, Young-Sun Lee, Gyun Jee Song, Gyun Jee Song, Hee-Sook Jun, Hee-Sook Jun, Hee-Sook Jun   +7 more
doaj   +1 more source

Modulating effects of RAMPs on signaling profiles of the glucagon receptor family

Acta Pharmaceutica Sinica B, 2022
Receptor activity-modulating proteins (RAMPs) are accessory molecules that form complexes with specific G protein-coupled receptors (GPCRs) and modulate their functions. It is established that RAMP interacts with the glucagon receptor family of GPCRs but
Lijun Shao, Yan Chen, Shikai Zhang, Zhihui Zhang, Yongbing Cao, Dehua Yang, Ming-Wei Wang   +6 more
doaj   +1 more source

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A–
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
core   +1 more source

Advantages of glucagon-like peptide-1 receptor agonists in the treatment of patients with type 2 diabetes mellitus: A review

Терапевтический архив, 2023
Glucagon-like peptide-1 receptor agonists (arGLP1) are an effective treatment for patients with type 2 diabetes mellitus (T2DM), mainly due to increasing insulin secretion and suppressing glucagon release by stimulating the respective receptors.
Tatiana Y. Demidova, Victoria V. Titova, Maryam Y. Izmaylova   +2 more
doaj   +1 more source