Results 21 to 30 of about 617,141 (296)

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

Cell Reports, 2016
In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during metabolic challenges such as those associated with pregnancy or high-fat diet.
Joana Almaça, Judith Molina, Danusa Menegaz, Alexey N. Pronin, Alejandro Tamayo, Vladlen Slepak, Per-Olof Berggren, Alejandro Caicedo   +7 more
doaj   +1 more source

Modulation of β-catenin signaling by glucagon receptor activation. [PDF]

PLoS ONE, 2012
The glucagon receptor (GCGR) is a member of the class B G protein-coupled receptor family. Activation of GCGR by glucagon leads to increased glucose production by the liver.
Jiyuan Ke, Chenghai Zhang, Kaleeckal G Harikumar, Cassandra R Zylstra-Diegel, Liren Wang, Laura E Mowry, Laurence J Miller, Bart O Williams, H Eric Xu   +8 more
doaj   +1 more source

Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion [PDF]

, 2010
Context: Glucagon-like peptide-1 (GLP-1) is produced by specialized cells in the gut and secreted in response to carbohydrates and lipids. The mechanisms regulating fat-stimulated GLP-1 release have, however, not been clarified in detail.
Schirra, Joerg, D'Amato, Massimo, Göke, Burkhard, Drewe, Juergen, Beglinger, Svetlana, Beglinger, Christoph   +5 more
core   +1 more source

New perspectives on the use of glucagon-like peptide 1 in diseases of the central nervous system

Current Issues in Pharmacy and Medical Sciences, 2023
Glucagon-like peptide 1 is a neuromodulatory peptide that regulates the carbohydrate metabolism. It can cross the blood-brain barrier, and, indeed, while mostly produced in the distal small intestine and colon, it is also synthesized in the nucleus of ...
Lupina Malgorzata, Listos Joanna
doaj   +1 more source

Betacellulin-Induced α-Cell Proliferation Is Mediated by ErbB3 and ErbB4, and May Contribute to β-Cell Regeneration

Frontiers in Cell and Developmental Biology, 2021
Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells.
Young-Sun Lee, Young-Sun Lee, Young-Sun Lee, Gyun Jee Song, Gyun Jee Song, Hee-Sook Jun, Hee-Sook Jun, Hee-Sook Jun   +7 more
doaj   +1 more source

Contribution of liver nerves, glucagon, and adrenaline to the glycaemic response to exercise in rats [PDF]

, 1994
The contribution of hepatic sympathetic innervation, glucagon and adrenaline to the glycaemic response to exercise was investigated in rats. Hepatically denervated (LDX) or sham operated (SHAM) rats with permanent catheters were therefore submitted to ...
B. AHRÉN, Dijk, G. van,, Bouws, G., van Dijk, Gertjan; id_orcid, Ahrén, B., Lindfeldt, J., KUVAKİ BALKAN, BAHAR, Bouws, G.,, SCHEURINK, AJW, AHREN, B, Balkan, B.,, Balkan, B., A. J. W. SCHEURINK, VAN DIJK, G, BOUWS, G, LINDFELDT, J, Scheurink, A.J.W., BALKAN, B, STEFFENS, AB, G. BOUWS, Steffens, A.B.,, B. BALKAN, Ahrén, B.,, Scheurink, A.J.W.,, A. B. STEFFENS, Steffens, A.B., Lindfeldt, J.,, G. VAN DIJK, van Dijk, Gertjan, VANDIJK, G, J. LINDFELDT   +30 more
core   +2 more sources

Modulating effects of RAMPs on signaling profiles of the glucagon receptor family

Acta Pharmaceutica Sinica B, 2022
Receptor activity-modulating proteins (RAMPs) are accessory molecules that form complexes with specific G protein-coupled receptors (GPCRs) and modulate their functions. It is established that RAMP interacts with the glucagon receptor family of GPCRs but
Lijun Shao, Yan Chen, Shikai Zhang, Zhihui Zhang, Yongbing Cao, Dehua Yang, Ming-Wei Wang   +6 more
doaj   +1 more source

Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells

FEBS Open Bio, 2015
Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown.
Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attayeb Mohsen, Tomomitsu Iida, Yamato Miura, Akira Sugawara, Kazuhiko Yanai   +7 more
doaj   +1 more source

Does glucagon have a positive inotropic effect in the human heart?

Cardiovascular Diabetology, 2018
Glucagon is considered to exert cardiostimulant effects, most notably the enhancement of heart rate and contractility, due to the stimulation of glucagon receptors associated with Gs protein stimulation which causes adenylyl cyclase activation and the ...
Jesus Hernández-Cascales
doaj   +1 more source

Advantages of glucagon-like peptide-1 receptor agonists in the treatment of patients with type 2 diabetes mellitus: A review

Терапевтический архив, 2023
Glucagon-like peptide-1 receptor agonists (arGLP1) are an effective treatment for patients with type 2 diabetes mellitus (T2DM), mainly due to increasing insulin secretion and suppressing glucagon release by stimulating the respective receptors.
Tatiana Y. Demidova, Victoria V. Titova, Maryam Y. Izmaylova   +2 more
doaj   +1 more source