Results 11 to 20 of about 617,141 (296)
Histologic distribution of insulin and glucagon receptors
Brazilian Journal of Medical and Biological Research, 1998 Insulin and glucagon are the hormonal polypeptides secreted by the B and A cells of the endocrine pancreas, respectively. Their major physiologic effects are regulation of carbohydrate metabolism, but they have opposite effects. Insulin and glucagon have
M. Watanabe +3 more
doaj +2 more sources
Glucagon and Its Receptors in the Mammalian Heart [PDF]
International Journal of Molecular Sciences, 2023 Glucagon exerts effects on the mammalian heart. These effects include alterations in the force of contraction, beating rate, and changes in the cardiac conduction system axis. The cardiac effects of glucagon vary according to species, region, age, and concomitant disease.
Joachim Neumann +3 more
core +7 more sources
The binding and activation of the glucagon-like peptide-1 receptor by exendin-4 [PDF]
, 2010 Background and purpose Exendin-4 (EX4) has the same physiological properties as glucagon-like peptide-1 (7-36)amide (GLP-1). EX4 has 50% identity with GLP-1, with an extra nine amino acids at its C-terminus.
Nasr, Elsayed Mohammed Nasr
core +6 more sources
Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model [PDF]
, 2013 Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer's patients, along with age, the presence of Aβ in the brain inhibits this process by reducing stem cell proliferation and cell ...
Vadivel Parthsarathy +7 more
core +6 more sources
Glucagon-like peptide-1 receptor imaging for localization of insulinomas [PDF]
, 2009 The surgical removal of insulinomas is hampered by difficulties to localize it using conventional radiological procedures. Recently these tumors were shown to exhibit a very high density of glucagon-like peptide-1 receptors (GLP-1R) in vitro that may be ...
Clerici, Thomas +21 more
core +3 more sources
Variation in responses to incretin therapy: Modifiable and non-modifiable factors
Frontiers in Molecular Biosciences, 2023 Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss.
Gregory O. Austin, Alejandra Tomas
doaj +1 more source
The Insulin Receptor Talks to Glucagon? [PDF]
Cell Metabolism, 2009 Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.
Gromada, J, Duttaroy, A, Rorsman, P
openaire +3 more sources
Aquaculture Reports, 2020 Since discovery, glucagon biology has remained enigmatic. Studies have shown that glucagon may have physiological effects beyond glucose regulation by binding to its receptor (Gcgr).
Chaobin Qin +7 more
doaj +1 more source
iScience, 2023 Summary: Crystal and cryo-EM structures of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) bound with their peptide ligands have been obtained with full-length constructs, indicating that the extracellular domain (ECD) is ...
Huixia Wang +5 more
doaj +1 more source
Glucagon-Like Peptide-1 Based Therapies: A New Horizon in Obesity Management [PDF]
Endocrinology and MetabolismObesity is a significant risk factor for health issues like type 2 diabetes and cardiovascular disease. It often proves resistant to traditional lifestyle interventions, prompting a need for more precise therapeutic strategies. This has led to a focus on
Jang Won Son, Soo Lim
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