Results 11 to 20 of about 43,486 (267)
Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression [PDF]
Communications Biology, 2021 Abstract Glucagon is a major regulator of metabolism and drugs targeting the glucagon receptor (GCGR) are being developed. Insight into tissue and cell-specific expression of the GCGR is important to understand the biology of glucagon and to differentiate between direct and indirect actions of glucagon.
Anna Billeschou Bomholt +15 more
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Frontiers in Endocrinology, 2021 The mammalian proglucagon gene (Gcg) encodes three glucagon like sequences, glucagon, glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 that are of similar length and share sequence similarity, with these hormones having cell surface receptors,
David M. Irwin, David M. Irwin
doaj +1 more source
Cardiovascular Diabetology, 2023 Background Glucagon is thought to increase heart rate and contractility by stimulating glucagon receptors and increasing 3′,5′-cyclic adenosine monophosphate (cAMP) production in the myocardium.
Ramón Aranda-Domene +4 more
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Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. [PDF]
PLoS ONE, 2015 This study evaluated the chronotropic and inotropic responses to glucagon in spontaneously beating isolated right atria of rat heart. For comparison, we also investigated the effects resulting from stimulating β-adrenoceptors with isoproterenol in this ...
Beatriz Merino +2 more
doaj +1 more source
Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and Glucagon. [PDF]
PLoS ONE, 2016 GLP-1 and glucagon regulate glucose metabolism through a network of metabolic pathways initiated upon binding to their specific receptors that belong to class B G-protein coupled receptors (GPCRs). The therapeutic potential of glucagon is currently being
Deena A Oren +5 more
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Glucagon Receptor Signaling and Glucagon Resistance [PDF]
International Journal of Molecular Sciences, 2019 Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas).
Lina Janah +8 more
openaire +3 more sources
Computational and Structural Biotechnology Journal, 2022 Class B G protein-coupled receptors (GPCRs) are important targets in the treatment of metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein complexes have been elucidated, the detailed activation mechanism of the ...
Ying Wang +9 more
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Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia
Folia Morphologica, 2020 BACKGROUND: Uraemia leads to a number of metabolic and hormonal disorders including defective carbohydrate metabolism. Endocannabinoids exert their effect on insulin and glucagon secretion via activation of specific receptors named CB1 and CB2.
P. Nowińska +3 more
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Nature Communications, 2022 Glucagon-like peptide-1 receptor (GLP1R) agonists are used to treat type 2 diabetes (T2D), and polyagonists targeting multiple hormone receptors are investigated as potential therapeutics for T2D.
Hongwei Jiang +12 more
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The Links of Ghrelin to Incretins, Insulin, Glucagon, and Leptin After Bariatric Surgery
Frontiers in Genetics, 2021 Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems. The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental ...
Daria Skuratovskaia +7 more
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