Results 11 to 20 of about 45,803 (309)

Glucagon and Its Receptors in the Mammalian Heart [PDF]

International Journal of Molecular Sciences, 2023
Glucagon exerts effects on the mammalian heart. These effects include alterations in the force of contraction, beating rate, and changes in the cardiac conduction system axis. The cardiac effects of glucagon vary according to species, region, age, and concomitant disease.
Joachim Neumann, Britt Hofmann, Stefan Dhein, Ulrich Gergs   +3 more
core   +7 more sources

The Links of Ghrelin to Incretins, Insulin, Glucagon, and Leptin After Bariatric Surgery

Frontiers in Genetics, 2021
Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems. The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental ...
Daria Skuratovskaia, Maria Vulf, Nataliya Chasovskikh, Aleksandra Komar, Elena Kirienkova, Egor Shunkin, Pavel Zatolokin, Larisa Litvinova   +7 more
doaj   +1 more source

The Insulin Receptor Talks to Glucagon? [PDF]

Cell Metabolism, 2009
Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.
Gromada, J, Duttaroy, A, Rorsman, P
openaire   +3 more sources

Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice [PDF]

Molecular Metabolism, 2022
Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice.Chronic effects of glucagon receptor signaling on lipid metabolism were studied using oral lipid tolerance tests (OLTTs) in ...
Galsgaard, Katrine D., Elmelund, Emilie, Johansen, Christian D., Bomholt, Anna B., Kizilkaya, Hüsün S., Ceutz, Frederik, Hunt, Jenna E., Kissow, Hannelouise, Winther-Sørensen, Marie, Sørensen, Charlotte M., Kruse, Thomas, Lau, Jesper F., Rosenkilde, Mette M., Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens J., Wewer Albrechtsen, Nicolai J.   +16 more
openaire   +4 more sources

Glucagon-like peptide-1 receptor imaging for localization of insulinomas [PDF]

, 2009
The surgical removal of insulinomas is hampered by difficulties to localize it using conventional radiological procedures. Recently these tumors were shown to exhibit a very high density of glucagon-like peptide-1 receptors (GLP-1R) in vitro that may be ...
Clerici, Thomas, Forrer, Flavio, Gloor, Beat, Reubi, Jean Claude, Rahel Sahli, Mäcke, Helmut R., Brändle, Michael, Beat Gloor, Martius, Ferdinand, Damian Wild, Reubi, Jean-Claude, Thomas Clerici, Flavio Forrer, Maecke, Helmut, Wild, Damian, Emanuel Christ, Ferdinand Martius, Christ, Emanuel, Sahli, Rahel, Jean Claude Reubi, Michael Brändle, Helmut Maecke   +21 more
core   +1 more source

Variation in responses to incretin therapy: Modifiable and non-modifiable factors

Frontiers in Molecular Biosciences, 2023
Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss.
Gregory O. Austin, Alejandra Tomas
doaj   +1 more source

Photoaffinity labeling of the glucagon receptor with a new glucagon analog [PDF]

European Journal of Biochemistry, 1984
The preparation, purification and characterization of N‐4‐azidophenylamidinoglucagon are described. This photoreactive peptide was found to be 50% as potent as native glucagon in competing with 125I‐labeled glucagon for binding to glucagon receptors on rat liver plasma membranes. Similarly, the analog was 50% as potent as native glucagon in its ability
D E, Wright, R, Horuk, M, Rodbell
openaire   +2 more sources

Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion [PDF]

, 2010
Context: Glucagon-like peptide-1 (GLP-1) is produced by specialized cells in the gut and secreted in response to carbohydrates and lipids. The mechanisms regulating fat-stimulated GLP-1 release have, however, not been clarified in detail.
Schirra, Joerg, D'Amato, Massimo, Göke, Burkhard, Drewe, Juergen, Beglinger, Svetlana, Beglinger, Christoph   +5 more
core   +1 more source

Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR

iScience, 2023
Summary: Crystal and cryo-EM structures of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) bound with their peptide ligands have been obtained with full-length constructs, indicating that the extracellular domain (ECD) is ...
Huixia Wang, Wanhui Hu, Tiandan Xu, Ya Yuan, Dongsheng Liu, Kurt Wüthrich   +5 more
doaj   +1 more source

Hepatic glucagon receptors expression in response to glucose, insulin, glucagon and immune challenge in grass carp (Ctenophcuyngodon idellus)

Aquaculture Reports, 2020
Since discovery, glucagon biology has remained enigmatic. Studies have shown that glucagon may have physiological effects beyond glucose regulation by binding to its receptor (Gcgr).
Chaobin Qin, Wenli Zhao, Guokun Yang, Hui Cao, Liping Yang, Xiaolin Meng, Xiao Yan, Guoxing Nie   +7 more
doaj   +1 more source