Results 31 to 40 of about 43,486 (267)
Modulating effects of RAMPs on signaling profiles of the glucagon receptor family
Acta Pharmaceutica Sinica B, 2022 Receptor activity-modulating proteins (RAMPs) are accessory molecules that form complexes with specific G protein-coupled receptors (GPCRs) and modulate their functions. It is established that RAMP interacts with the glucagon receptor family of GPCRs but
Lijun Shao +6 more
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Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice [PDF]
Molecular Metabolism, 2022 Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice.Chronic effects of glucagon receptor signaling on lipid metabolism were studied using oral lipid tolerance tests (OLTTs) in ...
Galsgaard, Katrine D. +16 more
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Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells
FEBS Open Bio, 2015 Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown.
Tadaho Nakamura +7 more
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Does glucagon have a positive inotropic effect in the human heart?
Cardiovascular Diabetology, 2018 Glucagon is considered to exert cardiostimulant effects, most notably the enhancement of heart rate and contractility, due to the stimulation of glucagon receptors associated with Gs protein stimulation which causes adenylyl cyclase activation and the ...
Jesus Hernández-Cascales
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Терапевтический архив, 2023 Glucagon-like peptide-1 receptor agonists (arGLP1) are an effective treatment for patients with type 2 diabetes mellitus (T2DM), mainly due to increasing insulin secretion and suppressing glucagon release by stimulating the respective receptors.
Tatiana Y. Demidova +2 more
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Photoaffinity labeling of the glucagon receptor with a new glucagon analog [PDF]
European Journal of Biochemistry, 1984 The preparation, purification and characterization of N‐4‐azidophenylamidinoglucagon are described. This photoreactive peptide was found to be 50% as potent as native glucagon in competing with 125I‐labeled glucagon for binding to glucagon receptors on rat liver plasma membranes. Similarly, the analog was 50% as potent as native glucagon in its ability
D E, Wright, R, Horuk, M, Rodbell
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Dual Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Receptor Agonists
Endocrinology Research and Practice, 2022 Glucagon-like peptide-1 is the most potent incretin secreted from the intestinal tract. It is synthesized by L-cells in the jejunum and distal ileum of the gastrointestinal system.
Dilek Tüzün
doaj
Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance
Molecular Metabolism, 2015 Objective: Glucagon receptor antagonists and humanized glucagon antibodies are currently studied as promising therapies for obesity and type II diabetes.
Mar Quiñones +6 more
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Translational Psychiatry, 2021 Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism.
Despoina Aslanoglou +15 more
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Potential Therapeutic Targeting Neurotransmitter Receptors in Diabetes
Frontiers in Endocrinology, 2022 Neurotransmitters are signaling molecules secreted by neurons to coordinate communication and proper function among different sections in the central neural system (CNS) by binding with different receptors.
Xiaohui Pan +5 more
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