Photoaffinity labeling of the glucagon receptor with a new glucagon analog [PDF]
European Journal of Biochemistry, 1984 The preparation, purification and characterization of N‐4‐azidophenylamidinoglucagon are described. This photoreactive peptide was found to be 50% as potent as native glucagon in competing with 125I‐labeled glucagon for binding to glucagon receptors on rat liver plasma membranes. Similarly, the analog was 50% as potent as native glucagon in its ability
D E, Wright, R, Horuk, M, Rodbell
openaire +2 more sources
Dual Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Receptor Agonists
Endocrinology Research and Practice, 2022 Glucagon-like peptide-1 is the most potent incretin secreted from the intestinal tract. It is synthesized by L-cells in the jejunum and distal ileum of the gastrointestinal system.
Dilek Tüzün
doaj
Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance
Molecular Metabolism, 2015 Objective: Glucagon receptor antagonists and humanized glucagon antibodies are currently studied as promising therapies for obesity and type II diabetes.
Mar Quiñones +6 more
doaj +1 more source
Translational Psychiatry, 2021 Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism.
Despoina Aslanoglou +15 more
doaj +1 more source
Potential Therapeutic Targeting Neurotransmitter Receptors in Diabetes
Frontiers in Endocrinology, 2022 Neurotransmitters are signaling molecules secreted by neurons to coordinate communication and proper function among different sections in the central neural system (CNS) by binding with different receptors.
Xiaohui Pan +5 more
doaj +1 more source
Hypothalamically-Induced Insulin Release and its Potentiation During Oral and Intravenous Glucose Loads [PDF]
, 1984 Male Wistar rats were provided with bilateral cannulas in the lateral hypothalamic area (LHA) and cannulas in the left and right jugular vein. Freely moving rats provided in this way with cannulas were infused with transmitters in the LHA and with ...
Steffens, A.B. +10 more
core +2 more sources
Glucagon Cell Hyperplasia and Neoplasia With and Without Glucagon Receptor Mutations [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2015 CONTEXT: Glucagon cell adenomatosis (GCA) was recently recognized as a multifocal hyperplastic and neoplastic disease of the glucagon cells unrelated to multiple endocrine neoplasia type 1 and von-Hippel-Lindau disease. OBJECTIVE: The study focused on the molecular analysis of the glucagon receptor (GCGR) gene in GCA and a description of the ...
Sipos, Bence +13 more
openaire +3 more sources
Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]
, 2012 Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a
Poyner, David +16 more
core +1 more source
Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Glucagon stimulates hepatic glucose production by activating specific glucagon receptors in the liver, which in turn increase hepatic glycogenolysis as well as gluconeogenesis and ureagenesis from amino acids.
Etienne Larger +10 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source