Results 41 to 50 of about 74,867 (310)
Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance
Molecular Metabolism, 2015 Objective: Glucagon receptor antagonists and humanized glucagon antibodies are currently studied as promising therapies for obesity and type II diabetes.
Mar Quiñones +6 more
doaj +1 more source
Potential Therapeutic Targeting Neurotransmitter Receptors in Diabetes
Frontiers in Endocrinology, 2022 Neurotransmitters are signaling molecules secreted by neurons to coordinate communication and proper function among different sections in the central neural system (CNS) by binding with different receptors.
Xiaohui Pan +5 more
doaj +1 more source
Translational Psychiatry, 2021 Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism.
Despoina Aslanoglou +15 more
doaj +1 more source
Glucagon receptor number and the MHC [PDF]
Nature, 1986 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/62898/1/323586b0 ...
openaire +3 more sources
Tail engagement of arrestin at the glucagon receptor
Nature, 2023 AbstractArrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating receptor internalization1,2. It has been proposed that the arrestin binds to the receptor in two different conformations, ‘tail’ and ‘core’, which were suggested to govern distinct processes of receptor ...
Kun Chen +12 more
openaire +2 more sources
A combined activation mechanism for the glucagon receptor [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance Understanding the mechanisms of activation of G-protein–coupled receptors (GPCRs) is a major issue in biophysics and pharmacology. This is particularly true for peptide-activated class B receptors, which are more flexible and have been studied less than class A.
Giulio Mattedi +3 more
openaire +5 more sources
Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Glucagon stimulates hepatic glucose production by activating specific glucagon receptors in the liver, which in turn increase hepatic glycogenolysis as well as gluconeogenesis and ureagenesis from amino acids.
Etienne Larger +10 more
doaj +1 more source
Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian +2 more
core +1 more source
Selective loss of adipose cell responsiveness to glucagon with growth in the rat
Journal of Lipid Research, 1972 In isolated fat cells, the same maximal rate of glycerol production can be induced by epinephrine or ACTH, alone or in combination with each other or with glucagon.
Vincent Manganiello, Martha Vaughan
doaj +1 more source
Different types of soluble fermentable dietary fibre decrease food intake, body weight gain and adiposity in young adult male rats [PDF]
, 2014 We thank Donna Wallace and the Rowett Animal House staff for the daily care of experimental rats, body weight and food intake measurements and MRI scanning, Vivien Buchan and Donna Henderson of the Rowett Analytical Department for proximate analyses and ...
Adam, Clare L +7 more
core +2 more sources