Results 271 to 280 of about 101,548 (353)

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Glucagon-like peptide-1 receptor agonist treatment reduces body weight and improves glycaemic outcomes in patients with concurrent overweight/obesity and type 1 diabetes: A systematic review and meta-analysis. [PDF]

Diabetes Obes Metab
Purcell AR, Zhen XM, Wong J, Glastras SJ.   +3 more
europepmc   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

Glucagon-like peptide-1 receptor agonist-induced cholecystitis and cholelithiasis: a real-world pharmacovigilance analysis using the FAERS database. [PDF]

Front Pharmacol
Tao C, Zhang Y, Wan T, Zhao W, Chen J, Wang K, Yang L, Wang G, Ding Q, Shang J, Zhou M.   +10 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Glucagon-Like Peptide 1 Receptor Agonist Stimulation Inhibits Laser-Induced Choroidal Neovascularization by Suppressing Intraocular Inflammation. [PDF]

Invest Ophthalmol Vis Sci
Machida A, Suzuki K, Nakayama T, Miyagi S, Maekawa Y, Murakami R, Uematsu M, Kitaoka T, Oishi A.   +8 more
europepmc   +1 more source

Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend Four weeks of semaglutide treatment causes significant reductions in total body weight, fat mass, lean mass, and grip strength in mice with diet induced obesity. Mice treated with semaglutide lost a greater amount of total body weight and fat mass compared to mice fed fed a calorie matched diet.
S. Jeromson, B. Baranowski, M. Akcan, B. D. Waters, K. Eisner, A. Bellucci, S. Trang, A. Abolhassani, M. A. Tello‐Palencia, A. Schweitzer, B. Stefanska, C. J. Mitchell, David C. Wright   +12 more
wiley   +1 more source

Effect of glucagon-like peptide-1 receptor agonist on paclitaxel induced neurotoxicity in dorsal root ganglion neuronal cells <i>in vitro</i>. [PDF]

Korean J Pain
Jung Y, Park S, Lim WY, Hong J, Baik J, Lee HJ, Kwon JY, Kim E.   +7 more
europepmc   +1 more source

Preoperative Glucagon-Like Peptide-1 Receptor Agonist Utilization and Association with Bariatric Surgery Outcomes. [PDF]

Obes Surg
AbuHasan Q, Funk LM, Holl JL, Draucker C, Grannis S, Bilimoria KY, Stefanidis D, Yuce TK.   +7 more
europepmc   +1 more source

Comparing SGLT2i and Other Oral Antidiabetic Drugs as Dual Therapy Add‐On to Metformin in Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
This systematic literature review and meta‐analysis compared sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2is) against other metformin‐containing oral dual‐therapies (ODTs) in type 2 diabetes mellitus. SGLT‐2i plus metformin exhibited overall comparable efficacy and safety, with a lower risk of hypoglycaemia and greater weight reduction than other ...
Yuhang Ma, Yi Lin, Xiaoying Ding, Yongde Peng   +3 more
wiley   +1 more source