Results 91 to 100 of about 258,084 (317)

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Dibutyltin disrupts glucocorticoid receptor function and impairs glucocorticoid-induced suppression of cytokine production [PDF]

, 2008
BACKGROUND: Organotins are highly toxic and widely distributed environmental chemicals. Dibutyltin (DBT) is used as stabilizer in the production of polyvinyl chloride plastics, and it is also the major metabolite formed from tributyltin (TBT) in vivo ...
Gumy Christel, Baker Michael E., Chandsawangbhuwana Charlie, Baker, Michael E, Michael E Baker, Dzyakanchuk Anna A., Gumy, C., Kratschmar, D. V., Odermatt, A., Michael E. Baker, Kratschmar, Denise V, Anna A Dzyakanchuk, Denise V Kratschmar, Kratschmar Denise V., Christel Gumy, Dzyakanchuk, A. A., Alex Odermatt, Chandsawangbhuwana, C., Odermatt Alex, Baker, M. E., Gumy, Christel, Dzyakanchuk, Anna A, Odermatt, Alex, Charlie Chandsawangbhuwana, Anna A. Dzyakanchuk, Chandsawangbhuwana, Charlie, Denise V. Kratschmar   +26 more
core   +1 more source

High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello, Rui Xiao, Xuemei Zhang, Jahan Jazayeri, Irit R. Rasooly, Pamela F. Weiss   +5 more
wiley   +1 more source

Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat [PDF]

, 2001
The experiments explored the nature and time course of changes in glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) binding in homogenates of various brain regions and pituitary of male Wistar rats following social defeat stress.
Horváth, K.M., Bohus, B., Bohus, B, Bauke Buwalda, Nyakas, C, Felszeghy, K., Felszeghy, K, Béla Bohus, Klára Felszeghy, Horváth, Katalin M.,, Koolhaas, J M, Buwalda, B, Boer, Sietse F. de,, Nyakas, Csaba,, Csaba Nyakas, Katalin M Horváth, de Boer, S.F., Felszeghy, Klára,, Koolhaas, J.M., Sietse F de Boer, Koolhaas, Jaap M.,, Nyakas, C., Buwalda, Bauke,, Horváth, K M, Buwalda, B., Bohus, Béla,, Jaap M Koolhaas   +26 more
core   +1 more source

Integrating Patient‐Reported Quality Measures in Systemic Lupus Erythematosus: Development of the American College of Rheumatology Implementation Guide

Arthritis Care &Research, EarlyView.
Objective To support high‐quality, patient‐centered care for systemic lupus erythematosus (SLE), the American College of Rheumatology (ACR) developed evidence‐based measures incorporating clinical and patient‐reported outcome measures (PROMs). Using the Consolidated Framework for Implementation Research (CFIR), we conducted semistructured interviews ...
Catherine Nasrallah, Cherish Wilson, Christine Hariz, Christie M. Bartels, Shanthini Kasturi, Wambui Machua, Amy Bennett, Kate Chiseri, Allison Plitman, Starla Hairston Blanks, April Jorge, Patti Katz, Jinoos Yazdany, Shivani Garg   +13 more
wiley   +1 more source

Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans: a systematic review [PDF]

, 2009
BACKGROUND: Synthetic glucocorticoids are commonly used in reproductive medicine. Fetal organ systems are highly sensitive to changes in the intrauterine environment, including overexposure to glucocorticoids.
Pryce, C R, Meinlschmidt, G., Meinlschmidt, M, Tegethoff, M., Pryce, C., Tegethoff, M, Christopher Pryce, Gunther Meinlschmidt, Marion Tegethoff   +8 more
core   +1 more source

IgG4-associated sclerosing cholangitis: a diagnosis that may change the course of events (review of the literature and a clinical case)

Alʹmanah Kliničeskoj Mediciny, 2018
Immunoglobulin G4-associated sclerosing cholangitis (IgG4-SC) can mimic primary sclerosing cholangitis, cholangiocarcinoma, and pancreatic adenocarcinoma. Its proper diagnosis allows for an adequate therapy and an improvement of the outcomes. The article
E. V. Vinnitskaya, T. Yu. Khaimenova, E. S. Sbikina, R. I. Alexandrova, Yu. G. Sandler   +4 more
doaj   +1 more source

Assessing the Sensitivity and the Clinical Impact of the 2023 American College of Rheumatology/EULAR Classification Criteria in Obstetric Antiphospholid Syndrome: Findings From a Multicenter Italian Cohort With a Long‐Term Follow‐Up

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli, Cecilia Nalli, Francesca Crisafulli, Carlo Garaffoni, Marcello Govoni, Giulia Voltarel, Alba C. Pozzi, Beatrice Maranini, Ettore Silvagni, Alessandra Bortoluzzi, Angela Tincani   +10 more
wiley   +1 more source

Glucocorticoid Effects on the Programming of AT1b Angiotensin Receptor Gene Methylation and Expression in the Rat. [PDF]

, 2010
Adverse events in pregnancy may 'programme' offspring for the later development of cardiovascular disease and hypertension. Previously, using a rodent model of programmed hypertension we have demonstrated the role of the renin-angiotensin system in this ...
Irina Bogdarina, Adrian J. L. Clark, Haase, A, Adrian J L Clark, Bogdarina, I, Andrea Haase, Clark, AJ, Haase Andrea, Langley-Evans Simon, Clark Adrian J. L., Bogdarina Irina, Irina Bogdarina, Simon Langley-Evans, Langley-Evans, S   +13 more
core   +1 more source

Sex‐dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice

Bioengineering & Translational Medicine
Traumatic brain injury (TBI) can have long‐lasting physical, emotional, and cognitive consequences due to the neurodegeneration caused by its robust inflammatory response.
Gherardo Baudo, Hannah Flinn, Morgan Holcomb, Anjana Tiwari, Sirena Soriano, Francesca Taraballi, Biana Godin, Assaf Zinger, Sonia Villapol   +8 more
doaj   +1 more source