Results 1 to 10 of about 1,498,808 (299)

Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

Nature Communications, 2016
To modulate gene expression, the glucocorticoid receptor binds to response elements (RE) that vary in sequence. Here, the authors show that RE sequences can modulate glucocorticoid receptor structure and activity, which might provide regulatory ...
Stefanie Schöne, Marcel Jurk, Mahdi Bagherpoor Helabad, Iris Dror, Isabelle Lebars, Bruno Kieffer, Petra Imhof, Remo Rohs, Martin Vingron, Morgane Thomas-Chollier, Sebastiaan H. Meijsing   +10 more
doaj   +1 more source

Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus

Cell Reports, 2019
Summary: Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine glucocorticoid ...
Matthew D. Taves, Paul R. Mittelstadt, Diego M. Presman, Gordon L. Hager, Jonathan D. Ashwell   +4 more
doaj   +1 more source

Polycystic ovary syndrome in a patient with type B insulin resistance syndrome can improve with glucocorticoid treatment: a case report and literature review

Endocrine Journal, 2023
Polycystic ovary syndrome (PCOS) frequently exhibits hyperinsulinemia due to insulin resistance, but there are many unknown aspects of this disease. This report presents the case of a 31-year-old woman with PCOS and type B insulin resistance syndrome ...
Tetsuhiro Watanabe, Saori Okabe, Shohei Sakamoto   +2 more
doaj   +1 more source

PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia

Nature Communications
The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic potential remains underexplored. Glucocorticoids are essential components of treatments for lymphoid cancers, but resistance, driven in part by epigenetic changes ...
Dominik Beck, Honghui Cao, Feng Tian, Yizhou Huang, Miao Jiang, Han Zhao, Xiaolu Tai, Wenqian Xu, Hansen J. Kosasih, David J. Kealy, Weiye Zhao, Samuel J. Taylor, Timothy A. Couttas, Gaoxian Song, Diego Chacon-Fajardo, Yashna Walia, Meng Wang, Adam A. Dowle, Andrew N. Holding, Katherine S. Bridge, Chao Zhang, Jin Wang, Jian-Qing Mi, Richard B. Lock, Charles E. de Bock, Duohui Jing   +25 more
doaj   +1 more source

The Glucocorticoid Receptor: A Revisited Target for Toxins

Toxins, 2010
The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid responses are critical for survival from a number of bacterial, viral and toxic insults, demonstrated by the fact that removal of the HPA axis or GR blockade enhances mortality ...
Jeanette I. Webster Marketon, Esther M. Sternberg   +1 more
doaj   +1 more source

Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury. [PDF]

PLoS ONE, 2014
Glucocorticoid regulates angiotensin II receptor (ATR) expression via activating glucocorticoid receptors and binding to glucocorticoid response elements.
Qin Xue, Andrew J Patterson, Daliao Xiao, Lubo Zhang   +3 more
doaj   +1 more source

GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers

Cell Reports, 2019
Summary: KDM1A-mediated H3K4 demethylation is a well-established mechanism underlying transcriptional gene repression, but its role in gene activation is less clear.
Erin A. Clark, Feizhen Wu, Yirui Chen, Paco Kang, Ursula B. Kaiser, Rui Fang, Yujiang G. Shi   +6 more
doaj   +1 more source

Effect of acute adrenalectomy on rat liver glucocorticoid receptor [PDF]

Archives of Biological Sciences, 2006
In order to improve current clinical treatment of human hypocortisolism, it is necessary to understand molecular aspects of this pathophysiology. In this study liver tissues from male Wistar rats were used as an experimental model to study structural and
Isenović Esma R., Radojčić Marija, Žakula Zorica, Korićanac Goran, Ribarac-Stepić Nevena   +4 more
doaj   +1 more source

Plasma Proteomics in Healthy Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies A Novel Proteomic Signature

Biomedicines, 2022
Significant inter-individual variation in terms of susceptibility to several stress-related disorders, such as myocardial infarction and Alzheimer’s disease, and therapeutic response has been observed among healthy subjects.
Nicolas C. Nicolaides, Manousos Makridakis, Rafael Stroggilos, Vasiliki Lygirou, Eleni Koniari, Ifigeneia Papageorgiou, Amalia Sertedaki, Jerome Zoidakis, Evangelia Charmandari   +8 more
doaj   +1 more source

Inhibiting glucocorticoid receptors enhances adult spinal cord neural stem cell activity and improves outcomes in spinal cord injury

Communications Biology
The spinal cord injury (SCI) microenvironment undergoes significant biochemical changes that influence the behavior of endogenous neural stem/progenitor cells (NSPCs), including elevated glucocorticoid levels.
Xuefeng Zhang, Siyuan Zhou, Shengyu Tang, Xiaotong Hou, Yonghui Cai, Changlong Hu   +5 more
doaj   +1 more source