Results 31 to 40 of about 142,613 (313)

Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells

Cancer Cell International, 2007
Background Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subsequent alteration of a complex ...
Thompson E Brad, Johnson Betty H, Garza Anna S, Miller Aaron L   +3 more
doaj   +1 more source

Glucocorticoid receptor modulators

Annales d'Endocrinologie, 2018
The glucocorticoid hormone cortisol acts throughout the body to support circadian processes and adaptation to stress. The glucocorticoid receptor is the target of cortisol and of synthetic glucocorticoids, which are used widely in the clinic. Both agonism and antagonism of the glucocorticoid receptor may be beneficial in disease, but given the wide ...
Meijer, O.C., Koorneef, L.L., Kroon, J.
openaire   +4 more sources

An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature

BMC Medical Genetics, 2018
Background Glucocorticoid resistance is a rare, sporadic or familial condition caused by mutation of the gene encoding the glucocorticoid receptor (GR).
Ágnes Molnár, Attila Patócs, István Likó, Gábor Nyírő, Károly Rácz, Miklós Tóth, Beatrix Sármán   +6 more
doaj   +1 more source

Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia [PDF]

, 2007
Objective Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R).
Hindmarsh, PC, Dattani, MT, Achermann, JC, Metherell, LA, Al-Ali, M, Brain, CE, Alzyoud, M, Clark, AJ, Lin, L, Clark, AJL   +9 more
core   +1 more source

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

Neural Regeneration Research
The hypothalamic–pituitary–adrenal axis regulates the secretion of glucocorticoids in response to environmental challenges. In the brain, a nuclear receptor transcription factor, the glucocorticoid receptor, is an important component of the hypothalamic ...
Chonglin Su, Taiqi Huang, Meiyu Zhang, Yanyu Zhang, Yan Zeng, Xingxing Chen   +5 more
doaj   +1 more source

Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice

Cell Reports, 2018
Summary: Glucocorticoids (GCs) are master regulators of systemic metabolism. Intriguingly, Cushing’s syndrome, a disorder of excessive GCs, phenocopies several menopause-induced metabolic pathologies.
Matthew A. Quinn, Xiaojiang Xu, Melania Ronfani, John A. Cidlowski   +3 more
doaj   +1 more source

Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts

Biomolecules, 2023
Over several decades, excess glucocorticoids (GCs) of endogenous or exogenous origin have been recognized to significantly inhibit collagen synthesis and accelerate skin aging. However, little is known regarding their molecular mechanisms.
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park   +4 more
doaj   +1 more source

Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old Problem

Cells, 2021
For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor alpha (GRα), have allowed for the use of these steroid hormones in
Lee-Maine L. Spies, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

SIRT1: potential target in glucocorticoid-resistant diseases

Frontiers in Immunology
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases.
Jun Xie, Siyi Che, Jiao Liu, Xiaoru Long
doaj   +1 more source

Insight into glucocorticoid receptor signalling through interactome model analysis. [PDF]

PLoS Computational Biology, 2017
Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research, high
Emyr Bakker, Kun Tian, Luciano Mutti, Constantinos Demonacos, Jean-Marc Schwartz, Marija Krstic-Demonacos   +5 more
doaj   +1 more source