Results 21 to 30 of about 127,973 (266)

Regulation of CYP3A genes by glucocorticoids in human lung cells [v2; ref status: indexed, http://f1000r.es/1z6]

F1000Research, 2013
Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts, Chad D Moore, Erin G Romero, Robert M Ward, Garold S Yost, Christopher A Reilly   +5 more
doaj   +1 more source

Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells

Cancer Cell International, 2007
Background Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subsequent alteration of a complex ...
Thompson E Brad, Johnson Betty H, Garza Anna S, Miller Aaron L   +3 more
doaj   +1 more source

An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature

BMC Medical Genetics, 2018
Background Glucocorticoid resistance is a rare, sporadic or familial condition caused by mutation of the gene encoding the glucocorticoid receptor (GR).
Ágnes Molnár, Attila Patócs, István Likó, Gábor Nyírő, Károly Rácz, Miklós Tóth, Beatrix Sármán   +6 more
doaj   +1 more source

Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts

Biomolecules, 2023
Over several decades, excess glucocorticoids (GCs) of endogenous or exogenous origin have been recognized to significantly inhibit collagen synthesis and accelerate skin aging. However, little is known regarding their molecular mechanisms.
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park   +4 more
doaj   +1 more source

Glucocorticoid receptor modulators

Annales d'Endocrinologie, 2018
The glucocorticoid hormone cortisol acts throughout the body to support circadian processes and adaptation to stress. The glucocorticoid receptor is the target of cortisol and of synthetic glucocorticoids, which are used widely in the clinic. Both agonism and antagonism of the glucocorticoid receptor may be beneficial in disease, but given the wide ...
Meijer, O.C., Koorneef, L.L., Kroon, J.
openaire   +4 more sources

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

Neural Regeneration Research
The hypothalamic–pituitary–adrenal axis regulates the secretion of glucocorticoids in response to environmental challenges. In the brain, a nuclear receptor transcription factor, the glucocorticoid receptor, is an important component of the hypothalamic ...
Chonglin Su, Taiqi Huang, Meiyu Zhang, Yanyu Zhang, Yan Zeng, Xingxing Chen   +5 more
doaj   +1 more source

Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice

Cell Reports, 2018
Summary: Glucocorticoids (GCs) are master regulators of systemic metabolism. Intriguingly, Cushing’s syndrome, a disorder of excessive GCs, phenocopies several menopause-induced metabolic pathologies.
Matthew A. Quinn, Xiaojiang Xu, Melania Ronfani, John A. Cidlowski   +3 more
doaj   +1 more source

Role of Glucocorticoids and Glucocorticoid Receptors in Glaucoma Pathogenesis

Cells, 2023
The glucocorticoid receptor (GR), including both alternative spliced isoforms (GRα and GRβ), has been implicated in the development of primary open-angle glaucoma (POAG) and iatrogenic glucocorticoid-induced glaucoma (GIG). POAG is the most common form of glaucoma, which is the leading cause of irreversible vision loss and blindness in the world ...
Pinkal D. Patel, Bindu Kodati, Abbot F. Clark   +2 more
openaire   +3 more sources

Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old Problem

Cells, 2021
For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor alpha (GRα), have allowed for the use of these steroid hormones in
Lee-Maine L. Spies, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

Evolution of glucocorticoid receptors with different glucocorticoid sensitivity [PDF]

Journal of Endocrinology, 2006
Glucocorticoids (GCs) are commonly used to treat a variety of immune diseases. However, the efficacy of treatment is greatly influenced by an individual variation in sensitivity to GCs, which is caused by differences in the glucocorticoid receptor (GR). The variable receptor profile results from variations in the GR gene, or alternative splicing of the
Stolte, H.H., Verburg-van Kemenade, B.M.L., Savelkoul, H.F.J., Flik, G.   +3 more
openaire   +4 more sources