Results 21 to 30 of about 1,498,808 (299)
Neurobiology of Stress, 2021 Chronic stress contributes to numerous human pathologies including cognition impairments and psychiatric disorders. Glucocorticoids are primary stress hormones that activate two closely related nuclear receptors, the glucocorticoid (GR) and ...
Robert H. Oakley +6 more
doaj +1 more source
Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair. [PDF]
Adv Sci (Weinh)Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Souali-Crespo S +11 more
europepmc +2 more sources
Mitochondrial Glucocorticoid Receptors and Their Actions [PDF]
International Journal of Molecular Sciences, 2021 Mitochondria are membrane organelles present in almost all eukaryotic cells. In addition to their well-known role in energy production, mitochondria regulate central cellular processes, including calcium homeostasis, Reactive Oxygen Species (ROS) generation, cell death, thermogenesis, and biosynthesis of lipids, nucleic acids, and steroid hormones ...
Kokkinopoulou, I., Moutsatsou, P.
openaire +3 more sources
The glucocorticoid receptor resource [PDF]
Nucleic Acids Research, 1996 The glucocorticoid receptor resource focuses on the structure-function relationships of the glucocorticoid receptor. As well as links to sequence and bibliographic databases via the World Wide Web, the database contains sequence comparisons of receptors from different species and source information for glucocorticoid receptor clones, probes, cell lines
Mark Danielsen, Elisabeth Martinez
openaire +3 more sources
Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms
Journal of Xenobiotics, 2022 Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this review,
Hong Lu
doaj +1 more source
Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]
, 1987 Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Strähle, Uwe +7 more
core +1 more source
The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 [PDF]
, 2007 Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti ...
Farquharson, C; id_orcid +7 more
core +1 more source
Scientific Reports, 2021 The glucocorticoid receptor is a key regulator of essential physiological processes, which under the control of the Hsp90 chaperone machinery, binds to steroid hormones and steroid-like molecules and in a rather complicated and elusive response ...
Anna Kaziales +2 more
doaj +1 more source
Glucocorticoid receptor activation by long acting steroids and its modification by inflammation [PDF]
, 2007 s: Glucocorticoids have an effective anti-inflammatory, anti-proliferative and immunomodulatory activity. Therefore this class of drugs is used worldwide for the treatment of inflammatory diseases and to prevent rejection following organ transplantation.
Yang, Jing-Qing
core +1 more source
How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
Nature Communications, 2021 Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy.
Dorien Clarisse, Karolien De Bosscher
doaj +1 more source