Results 171 to 180 of about 134,956 (333)

Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling

open access: yesCell Proliferation, EarlyView.
Paracrine FGF4 from EPI precursor cells promotes lactate synthesis within PrE precursor cells, while the increased lactate in turn stimulates FGF‐ERK signalling via lactate shuttling. The increased lactate in PrE precursor cells directly promotes PrE formation by elevating the level of histone lactylation. ABSTRACT Lactate has been widely recognised as
Xiao Hu   +9 more
wiley   +1 more source

Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activate hepatic gluconeogenesis. [PDF]

open access: yesMol Metab
Tan J   +8 more
europepmc   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone   +28 more
wiley   +1 more source

Control of Gluconeogenesis in Liver

open access: hybrid, 1968
John H. Exton, C R Park
openalex   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

open access: yesThe FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

Hepatic Ketogenesis and Gluconeogenesis in Humans [PDF]

open access: bronze, 1974
A. J. Garber   +3 more
openalex   +1 more source

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