Results 231 to 240 of about 162,740 (383)

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Saliva-derived exosomes regulate fibroblast metabolic reprogramming in skin wound healing. [PDF]

Front Cell Dev Biol
Song S, Xiang R, Chen S, Wu J, Chen W, Li X.   +5 more
europepmc   +1 more source

The Stimulation of the Mitochondrial Uncoupler-Dependent ATPase in Isolated Hepatocytes by Catecholamines and Glucagon and Its Relationship to Gluconeogenesis [PDF]

, 1979
M A Titheradge, Janet L. Stringer, Robert C. Haynes   +2 more
openalex   +1 more source

Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis

Diabetes, 2018
Junpei Wang, Weili Yang, Zhenzhen Chen, Ji Chen, Yuhong Meng, Biaoqi Feng, Libo Sun, L. Dou, Jian Li, Qinghua Cui, Jichun Yang   +10 more
semanticscholar   +1 more source

Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling

Cell Proliferation, EarlyView.
Paracrine FGF4 from EPI precursor cells promotes lactate synthesis within PrE precursor cells, while the increased lactate in turn stimulates FGF‐ERK signalling via lactate shuttling. The increased lactate in PrE precursor cells directly promotes PrE formation by elevating the level of histone lactylation. ABSTRACT Lactate has been widely recognised as
Xiao Hu, Yawen Tang, Wei Zhao, Juan Liu, Zhize Liu, Qianyin Yang, Meiqiang Chu, Jianhui Tian, Lei An, Shumin Wang   +9 more
wiley   +1 more source

Morin as a Modulator of Hepatic Glucose Fluxes: A Balance Between Antihyperglycemic Potential and Mitochondrial Toxicity. [PDF]

J Biochem Mol Toxicol
Nanami LF, Klosowski EM, Mito MS, Esquissato GNM, Viana GA, Abido ACO, Silva MCD, Mendonça APDS, de Melo GSR, Bueno PSA, Garcia FP, Bidoia DL, Nakamura TU, Nakamura CV, Ishii-Iwamoto EL, Ferro AP, Dos Santos WD, Ferrarese-Filho O, Marchiosi R, Constantin RP.   +19 more
europepmc   +1 more source

Correlation between Rates and Enzyme Levels of Increased Gluconeogenesis in Rat Liver and Kidney after Partial Hepatectomy [PDF]

, 1979
Norbert Katz
openalex   +1 more source

Clinical features and outcomes of diabetic ketoacidosis in patients using SGLT2 inhibitors: A systematic review and meta‐analysis

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are effective antihyperglycaemic agents; however, they also increase the risk of diabetic ketoacidosis (DKA). As the clinical evidence comparing DKA features between SGLT2i users and non‐users remains limited due to the low incidence of DKA, this study aimed to compare the clinical ...
Dahyeon Lee, Gayeong Seo, Yunha Kim, Jea Young Min, Jeong Yee   +4 more
wiley   +1 more source

Proteomic analysis unveils host-parasite interactions in Aedes togoi infected with Dirofilaria immitis and Brugia pahangi. [PDF]

PLoS One
Vinnie-Siow WY, Low VL, Chai HC, Lim YA, Tan TK.   +4 more
europepmc   +1 more source