Results 231 to 240 of about 171,466 (287)

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

Chelerythrine-Mediated Growth Inhibition and Resistance Mechanism in <i>Bacillus tropicus</i>. [PDF]

Microorganisms
Wang J, Wan H, Chai W, Cui D, Zhao M.
europepmc   +1 more source

Glycogen Storage Disease in Twins: When Two Lives Reflect One Silent Battle

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Early recognition of hepatomegaly, hypoglycemia, and elevated liver enzymes in infants is crucial for diagnosing glycogen storage disease. Liver biopsy with PAS–diastase staining provides definitive confirmation. Prompt metabolic management and regular follow‐up are essential to prevent progression of fibrosis and long‐term hepatic ...
Rajat Kumar Shah, Sajjad Ahmed Khan, Dikshya Devkota, Manjisha Aryal, Nishan Subedi, Basna Aryal, Binita Gurubacharya, Shamin Parajuli, Ashwini Gupta, Surya Bahadur Parajuli, Huma Kausar   +10 more
wiley   +1 more source

Berberine: A Rising Star in the Management of Type 2 Diabetes-Novel Insights into Its Anti-Inflammatory, Metabolic, and Epigenetic Mechanisms. [PDF]

Pharmaceuticals (Basel)
Liu D, Zhao L, Wang Y, Wang L, Wu D, Liu Y.   +5 more
europepmc   +1 more source

Biological Conversion of Formate to Organic Compounds: Toward a Sustainable Formate Bioeconomy

Carbon Energy, Volume 8, Issue 1, January 2026.
Formate bioconversion plays a crucial role in achieving renewable resource utilization and sustainable development. To tap its full potential, it is important to identify the most appropriate microbial hosts for incorporating formate into building blocks, design the most promising metabolic pathways for transmitting formate into central carbon ...
Jinyi Qian, Tiantian Chai, Chunlei Zhao, Xiulai Chen   +3 more
wiley   +1 more source

AARS1‐mediated AKR1B10 lactylation stabilizes an aerobic glycolysis‐positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
AKR1B10 confers lenvatinib resistance by enhancing aerobic glycolysis in HCC cells. AKR1B10 undergoes AARS1‐mediated lactylation at K173, stabilizing it by antagonizing ubiquitin‐proteasomal degradation. AKR1B10 promotes LDHA Y10 phosphorylation, boosting lactate production, which drives H3K18la‐mediated transcriptional upregulation of LDHA, creating a
Zijian Liu, Jingsheng Yuan, Shitong Su, Jiaqi Han, Ni Zeng, Yuhan Ma, Nianyong Chen, Tao Lv   +7 more
wiley   +1 more source

Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits

Judith Estrada-Meza, Jasmine Videlo, Clara Bron, Adeline Duchampt, C. Saint-Béat, Mickael Zergane, Marine Silva, Fabienne Rajas, Sébastien G. Bouret, Gilles Mithieux, Amandine Gautier‐Stein   +10 more
openalex   +1 more source

Concerted Actions of FoxO1 and PPARα in Hepatic Gene Expression and Metabolic Adaptation. [PDF]

Diabetes
Kitamoto T, Watanabe H, Miyachi Y, Miyabayashi M, Qiang L, Ajiro M, Yoshimi A, Maezawa Y, Yokote K, Accili D.   +9 more
europepmc   +1 more source

Insulin resistance indicators in aortic disease: A large cohort study

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Elevated TyG index and its related parameters were associated with an increased risk of aortic diseases in a prospective cohort of 386 063 participants. Mendelian randomisation suggested a potential causal link with AA but not with aortic dissection (AD). Abstract Background The triglyceride‐glucose index (TyG), a novel marker of insulin resistance, is
Zehua Shao, Zhongyuan Lu, Wanxin Duan, Lingchen Huang, Yangxue Sun, Lixi Gan, Yue Gu, Hongwei Guo   +7 more
wiley   +1 more source

The cancer-induced lactate load and oncologic remodeling hypothesis: lactate as a driver of biosynthesis and epigenetics in cancer. [PDF]

Front Oncol
Aydin H.
europepmc   +1 more source