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Food & Function, 2021
Dapagliflozin alleviates hyperglycemia by increasing glycosuria, but it induces renal gluconeogenesis, thus neutralizing its efficacy. Resveratrol (Rsv), a natural polyphenolic chemical, improves insulin sensitivity in type 2 diabetes (T2D).
Xiaoya Sun +6 more
semanticscholar +1 more source
Dapagliflozin alleviates hyperglycemia by increasing glycosuria, but it induces renal gluconeogenesis, thus neutralizing its efficacy. Resveratrol (Rsv), a natural polyphenolic chemical, improves insulin sensitivity in type 2 diabetes (T2D).
Xiaoya Sun +6 more
semanticscholar +1 more source
Renal gluconeogenesis: an underestimated role of the kidney in systemic glucose metabolism.
Nephrology, Dialysis and Transplantation, 2020Glucose levels are tightly regulated at all times. Gluconeogenesis is the metabolic pathway dedicated to glucose synthesis from non-hexose precursors. Gluconeogenesis is critical for glucose homoeostasis, particularly during fasting or stress conditions.
D. Legouis +3 more
semanticscholar +1 more source
Advances in Enzyme Regulation, 1964
Summary Following stimulation with adrenal steroids a series of metabolic changes occur leading to increased protein catabolism and increased glucose production. Specific hepatic enzymes whose activities are known to increase under these conditions are: glucose-6-phosphatase, phosphohexose isomerase, fructose diphosphatase, phosphoenolpyruvate ...
James Ashmore, T. Uete, S.R. Wagle
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Summary Following stimulation with adrenal steroids a series of metabolic changes occur leading to increased protein catabolism and increased glucose production. Specific hepatic enzymes whose activities are known to increase under these conditions are: glucose-6-phosphatase, phosphohexose isomerase, fructose diphosphatase, phosphoenolpyruvate ...
James Ashmore, T. Uete, S.R. Wagle
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International Journal of Molecular Sciences
Alanine and glutamine are the principal glucogenic amino acids. Most originate from muscles, where branched-chain amino acids (valine, leucine, and isoleucine) are nitrogen donors and, under exceptional circumstances, a source of carbons for glutamate ...
M. Holeček
semanticscholar +1 more source
Alanine and glutamine are the principal glucogenic amino acids. Most originate from muscles, where branched-chain amino acids (valine, leucine, and isoleucine) are nitrogen donors and, under exceptional circumstances, a source of carbons for glutamate ...
M. Holeček
semanticscholar +1 more source
Glucagon and Gluconeogenesis [PDF]
, 1983 Gluconeogenesis is the process whereby lactate, pyruvate, glycerol, and certain amino acids are converted to glucose and glycogen. The liver is the major site of gluconeogenesis, although the kidney becomes important during prolonged starvation. The most important function of gluconeogenesis is the maintenance of blood glucose levels during times when ...
Charles R. Park +2 more
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Gluconeogenesis and the peroxisome
Molecular and Cellular Biochemistry, 1997In this article, the capabilities of peroxisomal involvement in the gluconeogenetic processes of vertebrate animals are reviewed in the light of recent findings on peroxisomal metabolism and proliferation. It is demonstrated that the participation of this organelle affords the potential of alternative pathways for the conversion of triacylglycerols to ...
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Gluconeogenesis in the fetus and neonate
Seminars in Perinatology, 2000Gluconeogenesis (GNG), a key metabolic process, involves the formation of glucose and glycogen from non-glucose precursors via pyruvate. In the strict sense, it also includes the contribution of glycerol as well as recycled glucose carbon (Cori's cycle).
Prabhu S. Parimi, Satish C. Kalhan
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Glycolysis and Gluconeogenesis
2021Carbon metabolic pathways are called central metabolic pathways as these are the key pathways to generate energy and intermediates for the synthesis of biomolecules. The major carbon metabolic pathways are glycolysis/glycolytic pathway/Embden–Meyerhoff–Parnas pathway (EMP), pentose phosphate pathway (PPP) and Entner–Doudoroff (ED) pathway.
Rani Gupta, Namita Gupta
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Journal of Inherited Metabolic Disease, 1996
SummaryGluconeogenesis, or the formation of glucose from mainly lactate/pyruvate, glycerol and alanine, plays an essential role in the maintenance of normoglycaemia during fasting. Inborn deficiencies are known of each of the four enzymes of the glycolytic — gluconeogenic pathway that ensure a unidirectional flux from pyruvate to glucose: pyruvate ...
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SummaryGluconeogenesis, or the formation of glucose from mainly lactate/pyruvate, glycerol and alanine, plays an essential role in the maintenance of normoglycaemia during fasting. Inborn deficiencies are known of each of the four enzymes of the glycolytic — gluconeogenic pathway that ensure a unidirectional flux from pyruvate to glucose: pyruvate ...
openaire +2 more sources