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Glucose-6-Phosphate Dehydrogenase
1985Genetic systems have been of interest to human genetics mainly because they exhibit polymorphism in various populations, and therefore seem to be relevant to human evolution, or because they are associated with pathological manifestations. In addition, whereas frequently biological systems are easier to investigate in microorganisms or in experimental ...
L, Luzzatto, G, Battistuzzi
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Glucose 6-phosphate dehydrogenase and the kidney
Current Opinion in Nephrology and Hypertension, 2017Glucose 6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. G6PD is the main source of the essential cellular reductant, NADPH. The purpose of this review is to describe the biochemistry of G6PD and NADPH, cellular factors that regulate G6PD, normal physiologic roles of G6PD, and the pathogenic role altered ...
Netanya Y, Spencer, Robert C, Stanton
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Variants of Glucose 6-Phosphate Dehydrogenase
Annals of Internal Medicine, 1968Excerpt Glucose 6-phosphate dehydrogenase (G6PD) is the enzyme that catalyzes the first step in the pentose phosphate shunt.
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Glucose-6-phosphate dehydrogenase deficiency
Baillière's Clinical Haematology, 1992Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. Because its gene locus is on the X-chromosome it is more common in males than females in all populations. Prevalence rates vary from 62% among Kurdish Jews to the very low rates (0.1% or less in Japan, for example), which are compatible with sporadic cases arising
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Inhibition of glucose-6-phosphate dehydrogenase by steroids
Journal of Steroid Biochemistry, 1971Abstract By incubation of purified human placental glucose-6-phosphate dehydrogenase (G-6-PDH) with DHA. its conjugates or other derivatives, it could be demonstrated that DHA sulfate, phosphate and glucuronoside do not inhibit this enzyme. Conversely, DHA sulfatide proved to be extremely active in the enzyme inhibition test, whereas lipophite DHA ...
P, Benes, G W, Oertel
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Muscle glucose-6-phosphate dehydrogenase deficiency
Journal of Neurology, 1989Muscle glucose-6-phosphate dehydrogenase (G6PD) deficiency is described in four clinically heterogeneous patients: an athlete who developed myoglobinuria after physical exercise; a 7-year-old, mildly mentally retarded boy, who had episodes of dark urine and high creatine kinase; and two brothers of Sardinian origin, the elder showing moderate exercise ...
N, Bresolin +9 more
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Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity
Ageing Research Reviews, 2004Dehydroepiandrosterone (DHEA) is an abundantly produced adrenal steroid whose biological role has never been clarified. DHEA is a potent uncompetitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH) and as a consequence lowers NADPH levels and reduces NADPH-dependent oxygen-free radical production.
Arthur G, Schwartz, Laura L, Pashko
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Glucose-6-phosphate dehydrogenase variants in the chimpanzee
Biochemical Medicine, 1978Abstract Blood samples from 29 male and 25 female chimpanzees were examined for G-6-PD activity and electrophoretic mobility. Wild-type chimpanzee G-6-PD had a slightly slower electrophoretic mobility than human G-6-PD. Fast and slow variants of chimpanzee G-6-PD were detected both by starch gel electrophoresis and by gel isoelectric focusing.
E, Beutler, C, West
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Variants of Glucose-6-phosphate Dehydrogenase in Indonesia
Nature, 1969FOR the elucidation of paths of both migration and evolution, proteins offer certain advantages over other biological markers: qualitative alterations of proteins are usually transmitted in specific genetic patterns; each multicellular form of life has many proteins; and each protein is susceptible to genetic modification in many different ways.
H N, Kirkman, L L, Eng
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Glucose-6-phosphate dehydrogenase deficiency in neonates
The Indian Journal of Pediatrics, 2003Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited deficiency that may be the cause of neonatal hyperbilirubinemia, as has been found in several countries and among widely different ethnic groups, especially in Mediterranean region. Our aim was to study the prevalence of G6PD deficiency in relation to neonatal jaundice.From March 1998 ...
R, Iranpour, M R, Akbar, I, Haghshenas
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