Results 201 to 210 of about 1,221,230 (302)

Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Prostate cancer (PCa) is a leading male malignancy worldwide, with metabolic reprogramming being a critical hallmark of its progression. Extracellular vesicles (EVs) derived from tissues directly reflect the tumor microenvironment, offering unique insights into cancer pathophysiology that are unattainable through cell line or biofluid‐derived ...
Lijuan Yu   +4 more
wiley   +1 more source

Carbon Dot‐Based Mechanofluorescent Hydrogel with Tunable Fluorescence for Bioengineering Applications

open access: yesSmall, EarlyView.
Hybrid hydrogels embedded with carbon‐based quantum dots (CQDs) exhibit real‐time fluorescence change in response to compressive force. These hydrogels demonstrate multifunctionality, biocompatibility, and tunable mechanofluorescent behavior, enabling advanced applications in soft robotics.
Elahe Masaeli   +3 more
wiley   +1 more source

Catalytic Wiring of Enzymatic Cascades Using ROS‐Flux‐Regulated Biodegradable Borophene

open access: yesSmall, EarlyView.
Borophene‐modified electrodes facilitate enhanced electron transfer relative to bare electrodes, enabling efficient electrochemical communication with horseradish peroxidase (HRP) and glucose oxidase (GOx). The borophene–enzyme interface promotes electrocatalytic wiring of redox cascades, yielding amplified current outputs and positioning borophene as ...
Pranay Saha   +6 more
wiley   +1 more source

Motorized DNAzymes Drive Enhanced Electrochemical Biosensing for Rapid Bacterial Detection

open access: yesSmall Methods, EarlyView.
The micromotor DNAzyme analyzer (Motolyzer) enables sensitive electrochemical detection of Legionella pneumophila proteins in unprocessed samples with high specificity. Upon target recognition, DNAzymes actively release redox barcodes, which are detected on DNA‐functionalized electrodes.
Amir Ali Akhlaghi   +9 more
wiley   +1 more source

Organic Transistor‐Based Neuromorphic Electronics and Their Recent Applications

open access: yesSmall Methods, EarlyView.
This review highlights recent progress in organic neuromorphic electronics, showing how organic semiconductors enable synaptic and neuronal functions with low power, mechanical flexibility, and biocompatibility. By bridging materials, devices, and systems, organic platforms are accelerating brain‐inspired computing toward applications in artificial ...
Ziru Wang, Feng Yan
wiley   +1 more source

Advances in cholesterol and lipoproteins detection for healthcare: A review

open access: yesVIEW, EarlyView.
Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta   +7 more
wiley   +1 more source

D‐amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose D‐amino acid oxidase (DAO) has been developed as a chemogenetic tool, to precisely manipulate redox levels in tissues and cells by generating H2O2 in the presence of D‐amino acids. The enzyme's significant oxygen consumption during H2O2 production may influence cellular oxygen levels.
Wiebke Maurer   +10 more
wiley   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters   +6 more
wiley   +1 more source

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