Results 221 to 230 of about 276,644 (306)

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source

Safety of nonapeptide-pentapeptide mixture as a novel food pursuant to regulation (EU) 2015/2283. [PDF]

EFSA J
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Cámara M, Castenmiller J, De Henauw S, Jos Á, Maciuk A, Mangelsdorf I, McNulty B, Naska A, Pentieva K, Siani A, Thies F, Aguilera-Gómez M, Frenzel T, Marcon F, McArdle HJ, Moldeus P, Neuhäuser-Berthold M, Siskos A, Laganaro M, Nuin Garciarena I, Suriano F, Favata A, Pieger AM, Seminati F, Hirsch-Ernst KI.   +28 more
europepmc   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Gastric Emptying Is a Major Determinant of Postprandial Glycaemia and Prandial Insulin Requirement in Chinese With Type 1 Diabetes. [PDF]

Diabetes Obes Metab
Luo Y, Jin Z, Zhao Y, Luo Y, Xie C, Sun Y, Horowitz M, Jones KL, Rayner CK, Ma J, Wu T.   +10 more
europepmc   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

The need for pharmacotherapy among patients with one or more elevations on glucose tolerance test.

J Clin Endocrinol Metab
Comfort L, Benjamin A, Brenner E, Krantz D, Bonanno C, Levin H, Faizullabhoy A, Rochelson B.   +7 more
europepmc   +1 more source

Higher whole-body and exogenous postprandial glucose oxidation in the luteal versus follicular phase in healthy females. [PDF]

Physiol Rep
Govette A, West DWD, Pettit M, Antonen E, Koussiouris A, Moore DR, Gillen JB.   +6 more
europepmc   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

An Exploratory Study on Beneficial Effect of BE-FD-1 (Mineral-Enriched <i>Raphanus sativus</i> L. Leaf Extract) in High-Fat-Diet- and Streptozotocin-Induced Diabetic Mice. [PDF]

Nutrients
Kim SJ, Yoon KN, Hwang D, Park JE, Yang G, Moon YJ, Kim HW, Jang JE, Kim KH, Park M, Kang KS.   +10 more
europepmc   +1 more source

Toward the harmonization of bioequivalence guidelines in Europe: Commentary on the state of the art and future priorities under ICH M13A for immediate‐release oral forms

British Journal of Clinical Pharmacology, EarlyView.
Domenico Nocera, Giusi Forastiero, Andrea Logreco, Alessia Proietti, Antonio Galluccio, Carlotta Lunghi, Elisabetta Poluzzi, Fabrizio De Ponti   +7 more
wiley   +1 more source