Results 1 to 10 of about 632,919 (362)

mTORC2 sustains thermogenesis via Akt‐induced glucose uptake and glycolysis in brown adipose tissue [PDF]

open access: yesEMBO Molecular Medicine, 2016
Activation of non‐shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti‐obesity treatment. Moreover, cold‐induced glucose uptake could normalize blood glucose levels in insulin‐resistant patients.
Verena Albert   +8 more
doaj   +5 more sources

Upregulation of glucose uptake in L8 myotubes by the extract from Lagerstroemia speciosa: a possible mechanism of action [PDF]

open access: yesMaejo International Journal of Science and Technology, 2009
The leaf of Lagerstroemia speciosa L. is used as an anti-diabetic herbal remedy in many countries. In an attempt to discover mechanisms of action of the L.
Juntipa Purintrapiban
doaj   +2 more sources

Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake

open access: yesBiomolecules, 2022
Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 levels ...
Shawna L. McMillin   +12 more
doaj   +1 more source

Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake. [PDF]

open access: yesPLoS ONE, 2010
Glucose homeostasis is maintained by a balance between hepatic glucose production and peripheral glucose utilization. In skeletal muscle cells, glucose utilization is primarily regulated by glucose uptake.
Jong Hyun Kim   +5 more
doaj   +1 more source

The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41. [PDF]

open access: yesPLoS ONE, 2014
Since insulin resistance can lead to hyperglycemia, improving glucose uptake into target tissues is critical for regulating blood glucose levels. Among the free fatty acid receptor (FFAR) family of G protein-coupled receptors, GPR41 is known to be the ...
Joo-Hui Han   +5 more
doaj   +1 more source

Leucine Potentiates Glucose-mediated 18F-FDG Uptake in Brown Adipose Tissue via β-Adrenergic Activation

open access: yesBiomedicines, 2020
Significant depots of brown adipose tissue (BAT) have been identified in many adult humans through positron emission tomography (PET), with the amount of BAT being inversely correlated with obesity. As dietary activation of BAT has implications for whole
Brenda Huska   +3 more
doaj   +1 more source

Differential intracellular management of fatty acids impacts on metabolic stress-stimulated glucose uptake in cardiomyocytes

open access: yesScientific Reports, 2023
Stimulation of glucose uptake in response to ischemic metabolic stress is important for cardiomyocyte function and survival. Chronic exposure of cardiomyocytes to fatty acids (FA) impairs the stimulation of glucose uptake, whereas induction of lipid ...
Ettore Vanni   +3 more
doaj   +1 more source

Methamphetamine inhibits the glucose uptake by human neurons and astrocytes: stabilization by acetyl-L-carnitine. [PDF]

open access: yesPLoS ONE, 2011
Methamphetamine (METH), an addictive psycho-stimulant drug exerts euphoric effects on users and abusers. It is also known to cause cognitive impairment and neurotoxicity.
P M Abdul Muneer   +3 more
doaj   +1 more source

Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: There is considerable interest in identifying compounds that can improve glucose homeostasis. Skeletal muscle, due to its large mass, is the principal organ for glucose disposal in the body and we have investigated here if shikonin, a ...
Anette I Öberg   +8 more
doaj   +1 more source

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

open access: yeseLife, 2017
Insulin, downstream of Akt activation, promotes glucose uptake into fat and muscle cells to lower postprandial blood glucose, an enforced change in cellular metabolism to maintain glucose homeostasis.
Muheeb Beg   +4 more
doaj   +1 more source

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