Results 101 to 110 of about 680,023 (357)

Persistent organic pollutant burden, experimental POP exposure and tissue properties affect metabolic profiles of blubber from grey seal pups [PDF]

, 2018
Persistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife.
Bennett, Kimberley A., Debier, Cathy, Eppe, Gauthier, Hall, Ailsa J., Robinson, Kelly J., Thomé, Jean Pierre   +5 more
core   +4 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The effects of capillary transit time heterogeneity (CTH) on the cerebral uptake of glucose and glucose analogs:Application to FDG and comparison to oxygen uptake.

Frontiers in Computational Neuroscience, 2016
Glucose is the brain’s principal source of ATP, but the extent to which cerebral glucose consumption (CMRglc) is coupled with its oxygen consumption (CMRO2) remains unclear.
Hugo Angleys, Sune Nørhøj Jespersen, Sune Nørhøj Jespersen, Leif Østergaard, Leif Østergaard   +4 more
doaj   +1 more source

Methanolic leaf extract of Gymnema sylvestre augments glucose uptake and ameliorates insulin resistance by upregulating glucose transporter-4, peroxisome proliferator-activated receptor-gamma, adiponectin, and leptin levels in vitro. [PDF]

, 2016
The present study was undertaken to evaluate the effect of methanolic leaf extract of Gymnema sylvestre (MLGS) on glucose transport (GLUT) and insulin resistance in vitro. Materials and Methods: Peroxisome proliferator-activated receptor-gamma (PPAR-γ)
Ashok, G., Kumar, P.M., Manjunath, K., Venkataranganna, ., Viswanatha, G.L.   +4 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Early postnatal caloric restriction protects adult male intrauterine growth-restricted offspring from obesity. [PDF]

, 2012
Postnatal ad libitum caloric intake superimposed on intrauterine growth restriction (IUGR) is associated with adult-onset obesity, insulin resistance, and type 2 diabetes mellitus (T2DM).
Dai, Yun, Devaskar, Sherin U, Garg, Meena, Shin, Bo-Chul, Stout, David, Thamotharan, Manikkavasagar, Thamotharan, Shanthie   +6 more
core   +1 more source

¹⁸F-FDG PET/CT Scans Can Identify Sub-Groups of NSCLC Patients with High Glucose Uptake in the Majority of Their Tumor Lesions [PDF]

, 2020
Anne M. Hendriks, Adrienne H. Brouwers, Panagiotis Giannopoulos, Joop D. Lefrandt, Wim Timens, Harry J.M. Groen, Geertruida H. de Bock, Mathilde Jalving   +7 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

The novel family of Warbicin® compounds inhibits glucose uptake both in yeast and human cells and restrains cancer cell proliferation

Frontiers in Oncology
Many cancer cells share with yeast a preference for fermentation over respiration, which is associated with overactive glucose uptake and breakdown, a phenomenon called the Warburg effect in cancer cells. The yeast tps1Δ mutant shows even more pronounced
Ward Vanthienen, Ward Vanthienen, Juan Fernández-García, Juan Fernández-García, Maria Francesca Baietti, Elisa Claeys, Frederik Van Leemputte, Frederik Van Leemputte, Long Nguyen, Long Nguyen, Vera Goossens, Vera Goossens, Quinten Deparis, Quinten Deparis, Dorien Broekaert, Dorien Broekaert, Sophie Vlayen, Dominique Audenaert, Dominique Audenaert, Michel Delforge, Alessandro D’Amuri, Griet Van Zeebroeck, Griet Van Zeebroeck, Eleonora Leucci, Sarah-Maria Fendt, Sarah-Maria Fendt, Johan M. Thevelein, Johan M. Thevelein, Johan M. Thevelein   +28 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source