mTORC2 sustains thermogenesis via Akt‐induced glucose uptake and glycolysis in brown adipose tissue [PDF]
EMBO Molecular Medicine, 2016 Activation of non‐shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti‐obesity treatment. Moreover, cold‐induced glucose uptake could normalize blood glucose levels in insulin‐resistant patients.
Verena Albert +8 more
doaj +5 more sources
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle [PDF]
Molecular MetabolismObjectives: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical models of hyperglycemia.
Dipsikha Biswas +14 more
doaj +2 more sources
AICAR Inhibits Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes via an AMPK-Independent, ZMP-Dependent Mechanism [PDF]
CellsAMP-activated protein kinase (AMPK) is activated by reduced cellular energy charge and mimics the action of insulin in muscle by stimulating increased trafficking of GLUT4 to the plasma membrane.
Yazeed Alshuweishi +3 more
doaj +2 more sources
General aspects of muscle glucose uptake [PDF]
Anais da Academia Brasileira de Ciências, 2015 Glucose uptake in peripheral tissues is dependent on the translocation of GLUT4 glucose transporters to the plasma membrane. Studies have shown the existence of two major signaling pathways that lead to the translocation of GLUT4. The first, and widely investigated, is the insulin activated signaling pathway through insulin receptor substrate-1 and ...
ALVIM, RAFAEL O. +4 more
openaire +7 more sources
Upregulation of glucose uptake in L8 myotubes by the extract from Lagerstroemia speciosa: a possible mechanism of action [PDF]
Maejo International Journal of Science and Technology, 2009 The leaf of Lagerstroemia speciosa L. is used as an anti-diabetic herbal remedy in many countries. In an attempt to discover mechanisms of action of the L.
Juntipa Purintrapiban
doaj +2 more sources
Biomolecules, 2022 Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 levels ...
Shawna L. McMillin +12 more
doaj +1 more source
ARCGHR Neurons Regulate Muscle Glucose Uptake [PDF]
Cells, 2021 The growth hormone receptor (GHR) is expressed in brain regions that are known to participate in the regulation of energy homeostasis and glucose metabolism. We generated a novel transgenic mouse line (GHRcre) to characterize GHR-expressing neurons specifically in the arcuate nucleus of the hypothalamus (ARC).
Juliana Bezerra Medeiros de Lima +10 more
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Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake. [PDF]
PLoS ONE, 2010 Glucose homeostasis is maintained by a balance between hepatic glucose production and peripheral glucose utilization. In skeletal muscle cells, glucose utilization is primarily regulated by glucose uptake.
Jong Hyun Kim +5 more
doaj +1 more source
The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41. [PDF]
PLoS ONE, 2014 Since insulin resistance can lead to hyperglycemia, improving glucose uptake into target tissues is critical for regulating blood glucose levels. Among the free fatty acid receptor (FFAR) family of G protein-coupled receptors, GPR41 is known to be the ...
Joo-Hui Han +5 more
doaj +1 more source
Biomedicines, 2020 Significant depots of brown adipose tissue (BAT) have been identified in many adult humans through positron emission tomography (PET), with the amount of BAT being inversely correlated with obesity. As dietary activation of BAT has implications for whole
Brenda Huska +3 more
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