Results 11 to 20 of about 632,919 (362)
Effect of Jardiance on glucose uptake into astrocytomas. [PDF]
J NeurooncolAbstract Purpose SGLT2, the sodium glucose cotransporter two, is expressed in human pancreatic, prostate and brain tumors, and in a mouse cancer model SGLT2 inhibitors reduce tumor glucose uptake and growth. In this study we have measured the effect of a specific SGLT2 inhibitor, Jardiance® (Empagliflozin), on glucose ...
Ghezzi C +5 more
europepmc +5 more sources
Computational Modelling of Glucose Uptake in the Enterocyte [PDF]
Frontiers in Physiology, 2019 We describe an implemented model of glucose absorption in the enterocyte, as previously published by Afshar et al. Afshar et al. (2019), The model used mechanistic descriptions of all the responsible transporters and was built in the CellML framework.
Nima Afshar +5 more
openaire +8 more sources
General aspects of muscle glucose uptake [PDF]
Anais da Academia Brasileira de Ciências, 2015 Glucose uptake in peripheral tissues is dependent on the translocation of GLUT4 glucose transporters to the plasma membrane. Studies have shown the existence of two major signaling pathways that lead to the translocation of GLUT4. The first, and widely investigated, is the insulin activated signaling pathway through insulin receptor substrate-1 and ...
ALVIM, RAFAEL O. +4 more
openaire +6 more sources
Implications of Resveratrol on Glucose Uptake and Metabolism [PDF]
Molecules, 2017 Resveratrol—a polyphenol of natural origin—has been the object of massive research in the past decade because of its potential use in cancer therapy. However, resveratrol has shown an extensive range of cellular targets and effects, which hinders the use of the molecule for medical applications including cancer and type 2 diabetes.
Mónica Salas +3 more
openaire +4 more sources
Putting Rac1 on the Path to Glucose Uptake [PDF]
Diabetes, 2013 In spite of numerous and key advances in our understanding of insulin signaling, the molecular basis for impaired insulin-stimulated glucose uptake underlying insulin resistance remains unclear. Because skeletal muscle accounts for the majority of glucose utilization in the postprandial insulin-regulated state, defects in insulin action in muscle can ...
Assaf Rudich, Amira Klip
openaire +3 more sources
Frontiers in Immunology, 2022 BackgroundAbnormal intracellular glucose/fatty acid metabolism of T cells has tremendous effects on their immuno-modulatory function, which is related to the pathogenesis of autoimmune diseases.
Rong Tang +5 more
doaj +1 more source
Communications Biology, 2023 Although insulin mediated glucose uptake in skeletal muscle is a major mechanism ensuring glucose disposal in humans, glucose effectiveness, i.e., the ability of glucose itself to stimulate its own uptake independent of insulin, accounts for roughly half
Stefan Norlin +3 more
doaj +1 more source
Chronic Elevation of Skeletal Muscle [Ca2+]i Impairs Glucose Uptake. An in Vivo and in Vitro Study
Frontiers in Physiology, 2022 Skeletal muscle is the primary site of insulin-mediated glucose uptake through the body and, therefore, an essential contributor to glucose homeostasis maintenance. We have recently provided evidence that chronic elevated intracellular Ca2+ concentration
Arkady Uryash +4 more
doaj +1 more source
Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects. [PDF]
, 2015 We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of injured brains. To that end, we utilized dual isotope tracer [6,6-(2)H2]glucose, that is, D2-glucose, and [3-(13)C]lactate techniques involving arm vein tracer ...
Brooks, George A +6 more
core +1 more source
In vitro 2-deoxy-2-[18F]fluoro-D-glucose uptake: practical considerations [PDF]
, 2012 In oncology 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]-FDG), a glucose analogue, is the most used positron emission tomography (PET) tracer. There are however some limitations due to low metabolic activity or high surrounding physiological uptake in ...
Goethals, Ingeborg +4 more
core +1 more source