Results 311 to 320 of about 632,919 (362)

Insulin and Glucose Uptake by the Liver

Acta Physiologica Scandinavica, 1954
Summary.The rate of glucose uptake by the tissues after a large insulin dose has heen determined in normal, hepatectoniized and eviscerated cats. No difference in the rate of uptake, or in the dependence of the rate of uptake on the glucose concentration, was found among the three groups of experiments.Apparently in the cat the liver takes no part in ...
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GLUCOSE PHOSPHORYLATION AS A BARRIER TO MUSCLE GLUCOSE UPTAKE

Clinical and Experimental Pharmacology and Physiology, 2005
SUMMARY1. Glucose phosphorylation is the first irreversible step of the muscle glucose uptake pathway and is catalysed by a hexokinase isozyme.2. While glucose transport is the primary barrier to muscle glucose uptake during basal conditions, glucose phosphorylation becomes an important barrier to muscle glucose uptake during stimulated conditions such
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Osmotic Regulation of Cellular Glucose Uptake

2007
This chapter describes various approaches allowing the study of hyperosmolarity in the functions of 3T3-L1 adipocytes. Hyperosmolarity mimics insulin responses, such as glucose uptake and membrane ruffling, but also antagonizes these insulin effects, which can be evaluated in 3T3-L1 adipocytes.
Gual, Philippe, Gonzalez, Teresa, Gremeaux, Thierry, Le Marchand-Brustel, Yannick, Tanti, Jean-François, Marchand-Brustel, Yannick Le, Tanti, Jean‐françois   +6 more
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Discovery and Optimization of Glucose Uptake Inhibitors

Journal of Medicinal Chemistry, 2020
Aerobic glycolysis, originally identified by Warburg as a hallmark of cancer, has recently been implicated in immune cell activation and growth. Glucose, the starting material for glycolysis, is transported through the cellular membrane by a family of glucose transporters (GLUTs). Therefore, targeting glucose transporters to regulate aerobic glycolysis
Kevin G. Liu, Ji-In Kim, Kellen Olszewski, Anthony M. Barsotti, Koi Morris, Christophe Lamarque, Xuemei Yu, Jack Gaffney, Xiao-Jiang Feng, Jeegar P. Patel, Masha V. Poyurovsky   +10 more
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Reagents track glucose uptake [PDF]

C&EN Global Enterprise, 2019
The methods typically used for studying glucose metabolism in living systems, such as positron-emission tomography (PET) and fluorescence imaging, have drawbacks. PET is expensive and requires radioactive reagents with short half-lives. Fluorescence methods can suffer from high background and low tissue penetration.
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Protein kinase Cζ and glucose uptake

Biochemistry (Moscow), 2006
Protein kinase Czeta (PKCzeta) is a member of the PKC family, serving downstream of insulin receptor and phosphatidylinositol (PI) 3-kinase. Many evidences suggest that PKCzeta plays a very important role in activating glucose transport response. Not only insulin but also glucose and exercise can activate PKCzeta through diverse pathways.
Yi Li, Yongsheng Chang, Fude Fang, Xiaojun Liu, Lizhong Liu, Aibin He   +5 more
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Glucose uptake in dilated small intestine

Journal of Pediatric Surgery, 1998
The development of dilated small intestine in patients with short bowel syndrome results in increased mucosal surface area. This study examines whether the incremental increase in surface area leads to a proportional increase in absorptive function of the small intestine.Partial obstruction of the small intestine was created in rats by placing an ...
Mandy M. Lam, Jared M. Diamond, James C.Y. Dunn, Timothy P. O’Connor, Eric W. Fonkalsrud, Akemi L Kawaguchi   +5 more
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Regulation of glucose uptake in differentiated cells

Frontiers in Bioscience, 2001
Glucose uptake into the cell is mediated by a family of glycosylated membrane proteins, called glucose transporters (GTs) that are able to facilitate passive hexose transfer across the lipid plasma membrane. The tissue-specific transporter isoforms generally differ in their affinity to the natural substrate D-glucose according to the specific functions
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A bioluminescent assay for measuring glucose uptake

Analytical Biochemistry, 2016
Identifying activators and inhibitors of glucose uptake is critical for both diabetes management and anticancer therapy. To facilitate such studies, easy-to-use nonradioactive assays are desired. Here we describe a bioluminescent glucose uptake assay for measuring glucose transport in cells.
Natsuyo Aoyama, James J. Cali, Natasha Karassina, Michael P. Valley, Jolanta Vidugiriene, Coby B. Carlson   +5 more
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Inhibition of myocardial glucose uptake by cGMP

American Journal of Physiology-Heart and Circulatory Physiology, 1998
Guanosine 3′,5′-cyclic monophosphate (cGMP), a second messenger of nitric oxide (NO), regulates myocardial contractility. It is not known whether this effect is accompanied by a change in heart metabolism. We report here the effects of 8-bromoguanosine 3′,5′-cyclic monophosphate (8-BrcGMP), a cGMP analog, on regulatory steps of glucose metabolism in ...
Louis Hue, Jean-Louis Vanoverschelde, Yvan Fischer, Vinciane Gaussin, Sylvie Ponchaut, Christophe Depre   +5 more
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