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Inhibition of myocardial glucose uptake by cGMP
American Journal of Physiology-Heart and Circulatory Physiology, 1998Guanosine 3′,5′-cyclic monophosphate (cGMP), a second messenger of nitric oxide (NO), regulates myocardial contractility. It is not known whether this effect is accompanied by a change in heart metabolism. We report here the effects of 8-bromoguanosine 3′,5′-cyclic monophosphate (8-BrcGMP), a cGMP analog, on regulatory steps of glucose metabolism in ...
C, Depre +5 more
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A bioluminescent assay for measuring glucose uptake
Analytical Biochemistry, 2016Identifying activators and inhibitors of glucose uptake is critical for both diabetes management and anticancer therapy. To facilitate such studies, easy-to-use nonradioactive assays are desired. Here we describe a bioluminescent glucose uptake assay for measuring glucose transport in cells.
Michael P, Valley +5 more
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Regulation of Hepatic Glucose Uptake
Comprehensive Physiology, 2001Abstract The sections in this article are: Homeostatic Mechanisms Overview Insulin Glucagon
Roy Taylor, Gerald I. Shulman
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Glucose uptake in skeletal muscle
2023Glucose uptake occurs in skeletal muscle under basal conditions, and increases in response to stimuli such as insulin and exercise. Exercise is known to increase blood flow, and it appears that insulin has similar hemodynamic effects, including increased blood flow and capillary recruitment, which can modify the amount of glucose uptake occurring under
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Oxyntomodulin stimulates intestinal glucose uptake in rats
Gastroenterology, 1997Enteroglucagon peptides have long been proposed as mediators of intestinal adaptation, including mucosal growth and nutrient absorptive capacity. The hypothesis that infusions of oxyntomodulin, a bioactive form of enteroglucagon, would stimulate glucose and amino acid uptake was tested and its effects were compared with those of glucagon.Rats were ...
N L, Collie +3 more
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Cellular Regulation of Glucose Uptake by Glucose Transporter GLUT4
2014GLUT4 is regulated by its intracellular localization. In the absence of insulin, GLUT4 is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation (and contraction in muscle), GLUT4 translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu
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Studies of Peripheral Glucose Uptake During Sepsis
Archives of Surgery, 1979Glucose intolerance occurs in patients with sepsis, and resistance to insulin has been thought to be part of this process. To study this phenomenon, peritonitis was produced in rats by cecal ligation and puncture. One group was killed ten hours later (early sepsis).
K A, Wichterman, I H, Chaudry, A E, Baue
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Study of Glucose Uptake in Adipose Cells
2008Glucose is the main metabolic fuel in mammalian cells. Glucose entry into cells is facilitated by a family of ubiquitously expressed glucose transporter proteins. Typically, glucose transporters are localized on the plasma membrane. One notable exception is the glucose transporter isoform 4 (Glut4), which is specifically expressed in insulin sensitive ...
Jun, Shi, Konstantin V, Kandror
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Measurement of Glucose Uptake in Cultured Cells
Current Protocols in Pharmacology, 2011AbstractFacilitative glucose uptake transport systems are ubiquitous in animal cells and responsible for transporting glucose across the cell surface membrane. Evaluation of glucose uptake is crucial in the study of numerous diseases and metabolic disorders, such as myocardial ischemia, diabetes mellitus, and cancer.
Norio, Yamamoto +6 more
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