Results 41 to 50 of about 680,023 (357)

Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT

Bone Research, 2023
A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis. However, there is still a limited understanding of the in vivo glucose
Weizhao Lu, Yanhua Duan, Kun Li, Jianfeng Qiu, Zhaoping Cheng   +4 more
doaj   +1 more source

Enhanced T Cell Glucose Uptake Is Associated With Progression of Beta-Cell Function in Type 1 Diabetes

Frontiers in Immunology, 2022
BackgroundAbnormal intracellular glucose/fatty acid metabolism of T cells has tremendous effects on their immuno-modulatory function, which is related to the pathogenesis of autoimmune diseases.
Rong Tang, Ting Zhong, Li Fan, Yuting Xie, Juan Li, Xia Li   +5 more
doaj   +1 more source

Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. [PDF]

, 2020
Altered metabolism in pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs) contributes to the pathology of pulmonary hypertension (PH), but changes in substrate uptake and how substrates are utilized have not been fully ...
D' Alessandro, Angelo, Freeman, Scott, Graham, Brian B, Gu, Sue, Hernandez-Saavedra, Daniel, Kassa, Biruk, Kumar, Rahul, Lee, Michael H, Mickael, Claudia, Reisz, Julie A, Sanders, Linda, Stenmark, Kurt R, Tuder, Rubin M   +12 more
core   +1 more source

Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats [PDF]

, 2014
Chronic psychological stress is a prominent risk factor involved in the pathogenesis of many complex diseases, including major depression, obesity, and type II diabetes.
Abel, Adler, Ahima, Archuleta, Barsy, Bartness, Bartolomucci, Bartolomucci, Bjorntorp, Bose, Bost, Bradesi, Bray, Buren, Cai, Christiansen, Depke, Despres, Desreumaux, Edgar, Fortuno, Gonnissen, Griffin, Hawley, Hennings, Hirosumi, Hotamisligil, Hotamisligil, Hotamisligil, Karagiannides, Karagiannides, Kim, Kyrou, Lamounier-Zepter, Lehrke, Ma, Marra, Morino, Nieuwenhuizen, Ogden, Pechlivanova, Perrini, Razzouk, Rodriguez, Shively, Slentz, Speaker, Stubbs, Tanti, van Reedt Dortland, Willner, Yu, Yuan, Zhang   +53 more
core   +1 more source

Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts [PDF]

Endocrinology, 2016
Recent studies have identified the osteoblast as an insulin responsive cell that participates in global energy homeostasis. Here, we show that glucose transporter-4 (Glut4) is required for insulin-dependent uptake and oxidation of glucose in mature osteoblasts.
Zhu, Li, Julie L, Frey, G William, Wong, Marie-Claude, Faugere, Michael J, Wolfgang, Jason K, Kim, Ryan C, Riddle, Thomas L, Clemens   +7 more
openaire   +2 more sources

Methamphetamine inhibits the glucose uptake by human neurons and astrocytes: stabilization by acetyl-L-carnitine.

PLoS ONE, 2011
Methamphetamine (METH), an addictive psycho-stimulant drug exerts euphoric effects on users and abusers. It is also known to cause cognitive impairment and neurotoxicity.
P M Abdul Muneer, Saleena Alikunju, Adam M Szlachetka, James Haorah   +3 more
doaj   +1 more source

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. [PDF]

, 2017
The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation.
Braas, Daniel, Christofk, Heather, Clark, Peter M, Ding, Xueqin, Dunham, Christopher, Fu, Kai, Gimzewski, James K, Kurdistani, Siavash K, Lusis, Aldons J, Minami, Itsunari, Morselli, Marco, Nakano, Atsushi, Nakano, Haruko, Nakatsuji, Norio, Pappoe, Herman, Pellegrini, Matteo, Reue, Karen, Ribalet, Bernard, Sagadevan, Addelynn, Stieg, Adam Z, Vergnes, Laurent, Wu, Xiuju   +21 more
core   +2 more sources

Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters.

PLoS ONE, 2022
The fluorescent derivative of glucose, 2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)-amino]-D-glucose (2NBDG), is a widely used surrogate reagent to visualize glucose uptake in live cells at single cell resolution. Using CRISPR-Cas9 gene editing in 5TGM1
Lucas J D'Souza, Stephen H Wright, Deepta Bhattacharya   +2 more
doaj   +1 more source

Phytanic acid stimulates glucose uptake in a model of skeletal muscles, the primary porcine myotubes [PDF]

, 2013
BACKGROUND: Phytanic acid (PA) is a chlorophyll metabolite with potentials in regulating glucose metabolism, as it is a natural ligand of the peroxisome proliferator-activated receptor (PPAR) that is known to regulate hepatic glucose homeostasis.
Che, Brita Ngum, Hellgren, Lars, Nielsen, Jacob H, Oksbjerg, Niels, Young, Jette F.   +4 more
core   +3 more sources

β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathway

Molecular Metabolism, 2017
Objective: Today, the presence and activity of brown adipose tissue (BAT) in adult humans is generally equated with the induced accumulation of [2-18F]2-fluoro-2-deoxy-d-glucose ([18F]FDG) in adipose tissues, as investigated by positron emission ...
Jessica M. Olsen, Robert I. Csikasz, Nodi Dehvari, Li Lu, Anna Sandström, Anette I. Öberg, Jan Nedergaard, Sharon Stone-Elander, Tore Bengtsson   +8 more
doaj   +1 more source