Results 81 to 90 of about 680,023 (357)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Glucose uptake in mammalian cells measured by ICP-MS [PDF]

, 2021
Natalie J. Norman, Joyce Ghali, Tatiana L. Radzyukevich, Judith A. Heiny, Julio A. Landero Figueroa   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. [PDF]

, 2017
Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-driven glucose metabolism induces only minimal cell death, it lowers the ...
A Magi, AM Spence, Anthony Letai, AV Follis, AV Vaseva, BA Tannous, BJ Altman, Brian Higgins, C Tovar, CW Brennan, D Jiang, D Nathanson, DA Nathanson, DA Reardon, David A Nathanson, DR Green, E Cerami, E Strom, E Tasdemir, EH Cheng, EQ Lee, G Lessene, H Dai, H Takanaga, Harley I Kornblum, I Babic, I Vivanco, J Deng, J Gao, J Lee, J Lehár, J Montero, J Pomerantz, Jason T Lee, JC Liu, JE Chipuk, JE Chipuk, JE Chipuk, JIJ Leu, Jonathan E Tsang, JP Kruse, K Masui, L Qu, Laura Gosa, Lisa Ta, M Mihara, M-K Han, MG Vander Heiden, Mitra Dehghan Harati, MJ Lee, Nicholas A Bayley, OD Maddocks, P Nagesh Rao, Paul S Mischel, Peter M Clark, PM Clark, PY Wen, Q Ding, R Haq, RGW Verhaak, RJ DeBerardinis, Steven J Bensinger, TF Cloughesy, Timothy F Cloughesy, Veerle W Daniels, W Blake Gilmore, W Wei, WH Yang, William H Yong, Wilson X Mai, Y Zhang, Y Zhao   +71 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Effects of rapid or slow body weight reduction on glucose tolerance during equivalent weight loss in rats fed high-fat diet

Journal of Physical Fitness and Sports Medicine
Excess accumulation of visceral fat induces insulin resistance in skeletal muscle and impairs glucose tolerance. Although weight loss improves glucose tolerance by reducing visceral fat mass, the effects of the speed of weight loss on glucose metabolism ...
Yudai Nonaka, Makoto Inai, Shuhei Nishimura, Shogo Urashima, Shin Terada   +4 more
doaj   +1 more source

TXNIP regulates peripheral glucose metabolism in humans.

PLoS Medicine, 2007
BackgroundType 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying ...
Hemang Parikh, Emma Carlsson, William A Chutkow, Lovisa E Johansson, Heidi Storgaard, Pernille Poulsen, Richa Saxena, Christine Ladd, P Christian Schulze, Michael J Mazzini, Christine Bjørn Jensen, Anna Krook, Marie Björnholm, Hans Tornqvist, Juleen R Zierath, Martin Ridderstråle, David Altshuler, Richard T Lee, Allan Vaag, Leif C Groop, Vamsi K Mootha   +20 more
doaj   +1 more source

Increasing exercise intensity reduces heterogeneity of glucose uptake in human skeletal muscles. [PDF]

PLoS ONE, 2012
Proper muscle activation is a key feature of survival in different tasks in daily life as well as sports performance, but can be impaired in elderly and in diseases.
Ilkka Heinonen, Sergey V Nesterov, Jukka Kemppainen, Toshihiko Fujimoto, Juhani Knuuti, Kari K Kalliokoski   +5 more
doaj   +1 more source