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Causal association between serum bilirubin and ischemic stroke: multivariable Mendelian randomization. [PDF]

Epidemiol Health
Shin JW, Jung KJ, Ryu M, Kim J, Kimm H, Jee SH.   +5 more
europepmc   +1 more source

Identification of the Biotransformation Pathways of a Potential Oral Male Contraceptive, 11β-Methyl-19-Nortestosterone (11β-MNT) and Its Prodrugs: An In Vitro Study Highlights the Contribution of Polymorphic Intestinal UGT2B17. [PDF]

Pharmaceutics
Bachhav N, Singh DK, Blithe DL, Lee MS, Prasad B.   +4 more
europepmc   +1 more source

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Uridine diphosphate glucuronosyltransferase 1A1

Xenobiotica, 2019
The role that the phase-II reaction, glucuronidation, plays in the biotransformation of endo and xenobiotics is discussed with particular emphasis given to the UGT1A1 isoenzyme. This individual isoenzyme is responsible for both the mono and di-glucuronidation of bilirubin together with the glucuronidation of a number of xenobiotics of clinical interest
G. Steventon
openaire   +4 more sources

UDP-Glucuronosyltransferases

Current Drug Metabolism, 2000
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King, G R, Rios, M D, Green, T R, Tephly   +3 more
openaire   +2 more sources

Steroid UDP glucuronosyltransferases

The Journal of Steroid Biochemistry and Molecular Biology, 1992
The glucuronidation of steroids is a major process necessary for their elimination in the bile and urine. In general, steroid glucuronides are biologically less reactive than their parent steroids. However, in some cases often associated with disease and steroid therapy, more reactive or toxic glucuronides may be formed.
Louise Rodbourne, Peter I. Mackenzie, Steven Stranks   +2 more
openaire   +3 more sources

Characterization of UDP-glucuronosyltransferase genes and their possible roles in multi-insecticide resistance in Plutella xylostella (L.).

Pest Management Science, 2018
BACKGROUND Uridine diphosphate-glucuronosyltransferases (UGTs), as multifunctional detoxification enzymes, play important roles in the biotransformation of various compounds. However, their roles in insecticide resistance are still unclear.
Xiuxia Li, Haiyan Shi, Xiwu Gao, P. Liang   +3 more
semanticscholar   +1 more source