Results 241 to 250 of about 24,745 (276)

UDP-Glucuronosyltransferase in gilbert’s syndrome

Pathology, 1996
The diagnosis of Gilbert's syndrome, a condition characterised by mild jaundice related to chronic unconjugated hyperbilirubinemia, is often presumptive and the pathogenesis is incompletely understood. It would be of interest to develop an immunohistochemical staining method to confirm a diagnosis of Gilbert's syndrome.
J. Rhode, Amar P. Dhillon, H.S. Debinski, Paul V. Desmond, Peter I. Mackenzie, C.S. Lee   +5 more
openaire   +3 more sources

UDP-Glucuronosyltransferases*

2010
The UDP-glucuronosyltransferases (UGT) are enzymes that conjugate glucuronic acid to nucleophilic O, N, S, and C atoms on lipophilic compounds via a nucleophilic bimolecular (SN2) mechanism. The aglycone substrates glucuronidated include drugs, environmental toxins, and endogenous compounds such as bilirubin and steroid hormones.
Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Miners, John Oliver   +2 more
openaire   +3 more sources

Immobilized glucuronosyltransferase for the synthesis of conjugates

Journal of Medicinal Chemistry, 1976
Partially purified rabbit liver UDPglucuronosyltransferase is immobilized on agarose by the cyanogen bromide activation method. Both soluble and matrix-bound enzyme preparations display very similar Km and pH optimum. The storage stability of the immobilized enzyme at 4 degrees is 5-10 times improved over the soluble preparations.
Donald W. MacGlashan, Catherine Fenselau, Indu Parikh   +2 more
openaire   +3 more sources

Heterodimerization of Human UDP-Glucuronosyltransferase 1A9 and UDP-Glucuronosyltransferase 2B7 Alters Their Glucuronidation Activities

Drug Metabolism and Disposition, 2023
Human UDP-glucuronosyltransferases (UGTs) play a pivotal role as prominent phase II metabolic enzymes, mediating the glucuronidation of both endobiotics and xenobiotics. Dimerization greatly modulates the enzymatic activities of UGTs. In this study, we examined the influence of three mutations (H35A, H268Y, and N68A/N315A) and four truncations (signal ...
Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang, Su Zeng   +5 more
openaire   +2 more sources

Regulation of UDP glucuronosyltransferases in the gastrointestinal tract

Toxicology and Applied Pharmacology, 2004
The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution pattern that is subject to ...
Gregory, Philip A, Lewinsky, Rikke Holm, Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne   +3 more
openaire   +4 more sources

GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE

Drug Metabolism and Disposition, 2004
This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology.
Wells, Peter G, Hansen, Antony J, Gregory, Philip A, Ishii, Yuji, Mackenzie, Peter Ian, Guillemette, Chantal, Chowdhury, Jayanta Roy, Choudhury, Namita R, Kessler, Fay K, Kim, Perry M, Ritter, Joseph K   +10 more
openaire   +4 more sources

Structure of UDP‐Glucuronosyltransferases in Membranes

2005
This chapter presents the most recent experimental approaches to the investigation of UDP-glucuronosyltransferase (UGTs) in membranes. The first topic described is the subcellular localization of UGTs with special emphasis on the association of these proteins with the endoplasmic reticulum (ER).
Sylvie Fournel-Gigleux, Jacques Magdalou, Anna Radominska-Pandya, Mohamed Ouzzine   +3 more
openaire   +2 more sources

STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES

Clinical and Experimental Pharmacology and Physiology, 1997
SUMMARY1. The uridine diphosphate (UDP)‐glucuronosyltransferases (UGT) are a family of enzymes that catalyse the covalent addition of glucuronic acid to a wide range of lipophilic chemicals. They play a major role in the detoxification of many exogenous and endogenous compounds by generating products that are more polar and, thus, more readily excreted
Robyn Meech, Peter I. Mackenzie
openaire   +3 more sources

UDP glucuronosyltransferase in the cirrhotic rat liver

Journal of Gastroenterology and Hepatology, 1996
AbstractIn patients with cirrhosis, the elimination of drugs metabolized by glucuronidation is relatively preserved, in comparison with the metabolism of drugs by oxidation. This study explores this phenomenon at a molecular level. In cirrhotic rat livers the content of UDP‐glucuronosyltransferase (UGT) was examined by immunohistochemistry and ...
Thomas R. Tephly, C.S. Lee, H.S. Debinski, Peter I. Mackenzie, Paul V. Desmond, Danks Ja, Maurice L. Mashford, Mitchell D. Green   +7 more
openaire   +3 more sources

Uridine diphosphate glucuronosyltransferase 1A1

Xenobiotica, 2019
The role that the phase-II reaction, glucuronidation, plays in the biotransformation of endo and xenobiotics is discussed with particular emphasis given to the UGT1A1 isoenzyme. This individual isoenzyme is responsible for both the mono and di-glucuronidation of bilirubin together with the glucuronidation of a number of xenobiotics of clinical interest
openaire   +3 more sources