Results 251 to 260 of about 30,656 (311)

The UDP-Glucuronosyltransferases as Oligomeric Enzymes

Current Drug Metabolism, 2008
The UDP-glucuronosyltransferases (UGTs) are integral membrane proteins of the endoplasmic reticulum that play important roles in the defense against potentially hazardous xenobiotics. The UGTs also participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones.
Moshe Finel, Mika Kurkela
openaire   +3 more sources

Regulation of UDP Glucuronosyltransferase Genes

Current Drug Metabolism, 2003
The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs.
Nishiyama, Takahito, Xie, Wen, Gregory, Philip A, Lewinsky, Rikke Holm, Jorgensen, Bo R, Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Radominska-Pandya, A   +7 more
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Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.

Molecular Pharmaceutics, 2016
Protein expression levels of drug-metabolizing enzymes and transporters in human jejunal tissues excised from morbidly obese subjects during gastric bypass surgery were evaluated using quantitative targeted absolute proteomics.
Eisuke Miyauchi, M. Tachikawa, X. Declèves, Yasuo Uchida, J. Bouillot, C. Poitou, J. Oppert, S. Mouly, J. Bergmann, T. Terasaki, J. Scherrmann, C. Lloret-Linares   +11 more
semanticscholar   +1 more source

Regulation of Mammalian UDP-Glucuronosyltransferases

Current Drug Metabolism, 2018
UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity of UGTs are regulated by multiple dimensions of mechanisms and can be influenced by diverse ...
Haiping Hao, Guoxiu Cao, Hong Wang, Guangji Wang   +3 more
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Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases [PDF]

Expert Opinion on Drug Metabolism & Toxicology, 2015
The uridine diphosphate (UDP)-glucuronosyltransferase (UGT) superfamily of enzymes (EC 2.4.1.17) conjugates glucuronic acid to an aglycone substrate to make them more polar and readily excreted. In general, this reaction terminates the activities of chemicals, drugs and toxins, although occasionally a more active or toxic species is produced.In ...
Abby C. Collier, Zoe Riches
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Human UDP-Glucuronosyltransferase 2B7

Current Drug Metabolism, 2001
UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar donor.
Anna Radominska-Pandya, Joanna M. Little, Piotr J. Czernik   +2 more
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UDP-Glucuronosyltransferase in gilbert’s syndrome

Pathology, 1996
The diagnosis of Gilbert's syndrome, a condition characterised by mild jaundice related to chronic unconjugated hyperbilirubinemia, is often presumptive and the pathogenesis is incompletely understood. It would be of interest to develop an immunohistochemical staining method to confirm a diagnosis of Gilbert's syndrome.
J. Rhode, Amar P. Dhillon, H.S. Debinski, Paul V. Desmond, Peter I. Mackenzie, C.S. Lee   +5 more
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Immobilized glucuronosyltransferase for the synthesis of conjugates

Journal of Medicinal Chemistry, 1976
Partially purified rabbit liver UDPglucuronosyltransferase is immobilized on agarose by the cyanogen bromide activation method. Both soluble and matrix-bound enzyme preparations display very similar Km and pH optimum. The storage stability of the immobilized enzyme at 4 degrees is 5-10 times improved over the soluble preparations.
Donald W. MacGlashan, Catherine Fenselau, Indu Parikh   +2 more
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UDP-Glucuronosyltransferases*

2010
The UDP-glucuronosyltransferases (UGT) are enzymes that conjugate glucuronic acid to nucleophilic O, N, S, and C atoms on lipophilic compounds via a nucleophilic bimolecular (SN2) mechanism. The aglycone substrates glucuronidated include drugs, environmental toxins, and endogenous compounds such as bilirubin and steroid hormones.
Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Miners, John Oliver   +2 more
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Regulation of UDP glucuronosyltransferases in the gastrointestinal tract

Toxicology and Applied Pharmacology, 2004
The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution pattern that is subject to ...
Gregory, Philip A, Lewinsky, Rikke Holm, Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne   +3 more
openaire   +4 more sources