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A Major Genotype in UDP-glucuronosyltransferase 2B15
Drug Metabolism and Pharmacokinetics, 2002A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'.
Toshihiko Fujii +6 more
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STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*
Drug Metabolism Reviews, 1999UDP-Glucuronosyltransferases (UGTs) are glycoproteins localized in the endoplasmic reticulum (ER) which catalyze the conjugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GIcUA) as the sugar donor. Glucuronidation is a major factor in the elimination of lipophilic compounds from the body. In
Anna Radominska-Pandya +4 more
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Transcriptional Regulation of UDP-Glucuronosyltransferases
2009Totowa, New ...
Xie, Wen +2 more
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The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A
Xenobiotica, 20161. The exposed level of vitamin A in plasma might be exceeded due to the both inadvertent and clinical utilization. The adverse effects of vitamin A have been frequently reported, however, the mechanism remains unclear. The inhibition of vitamin A on the activity of UDP-glucuronosyltransferases (UGTs) was determined using in vitro incubation system to ...
Liang-Liang Zhu +9 more
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Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2011UDP glucuronosyltransferases (UGTs) are important for the metabolism of many drugs. To understand the ontogeny of these enzymes in sheep (Ovis aries), knowledge of their expression levels at different developmental stages is important. cDNA sequences of six UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) were cloned in sheep liver by rapid ...
Geoff Hammond +4 more
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Metabolism of Endobiotics and Xenobiotics by UDP-Glucuronosyltransferase
1997Publisher Summary All organisms are exposed to a number of chemical compounds that are toxic were it not for metabolic mechanisms available to the organism to moderate their effects. Chemical substances may be xenobiotics, such as drugs, or compounds presented to the organism from environmental or dietary sources.
Mitchell D. Green +5 more
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Roles of UDP-Glucuronosyltransferases in Chemical Carcinogenesi
Critical Reviews in Biochemistry and Molecular Biology, 1991UDP-glucuronosyltransferases (UGT) play a major role in the elimination of nucleophilic metabolites of carcinogens, such as phenols and quinols of polycyclic aromatic hydrocarbons. In this way they prevent their further oxidation to electrophiles, which may react with DNA, RNA, and protein.
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UDP-Glucuronosyltransferase inhibitors
European Journal of Drug Metabolism and Pharmacokinetics, 1998Zlatina Naydenova +2 more
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Characterisation and Regulation of UDP-Glucuronosyltransferases
1991Many drugs, xenobiotics and endogenous compounds are metabolised via common two stage pathway, which was designated as phase 1 (oxidative metabolism) and phase II (conjugation) by Williams (1). Glucuronidation reactions catalysed by the UDP-glucuronosyltransferases (UDPGTs) is arguably the major conjugation system of phase II metabolism. The metabolism
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