Results 271 to 280 of about 30,656 (311)

Natural and synthetic inhibitors of UDP-glucuronosyltransferase

Pharmacology & Therapeutics, 2001
Glucuronidation is a major detoxification pathway in vertebrates. The reaction is catalyzed by a family of UDP-glucuronosyltransferases (UGTs) and involves conjugation of many endobiotic and xenobiotic substances with glucuronic acid, forming inactive water-soluble glucuronides.
Zlatina Naydenova, Svetla Lozeva, Konstantin Grancharov, Evgeny Golovinsky   +3 more
openaire   +2 more sources

Development of Human Liver UDP-Glucuronosyltransferases

Developmental Pharmacology and Therapeutics, 1989
The development of multiple UDPGT activities towards eight substrates has been studied in fetal term and adult post-mortem (less than 5 h after death) liver samples. Most fetal and term liver activities were less than 14% of adult values, except that towards 5-hydroxytryptamine which was present in fetal and term liver at adult levels.
David Harding, Michael W.H. Coughtrie, Robert Hume, Sylvie Fournel-Gigleux, Brian Burchell, Michael R. Jackson, J. E. A. Leakey   +6 more
openaire   +3 more sources

UDP-glucuronosyltransferases: a family of detoxifying enzymes

Trends in Pharmacological Sciences, 1990
Glucuronidation is an important process in the metabolism of xenobiotic and endogenous substances leading to enhancement of excretion of these compounds from the body. A multigene family encodes a number of UDP-glucuronosyltransferase enzymes which catalyse this route of metabolism.
Brian Burchell, Thomas R. Tephly
openaire   +3 more sources

Function, genetic polymorphism, and transcriptional regulation of human UDP-glucuronosyltransferase (UGT) 1A1.

Drug Metabolism and Pharmacokinetics, 2013
  Human UDP-glucuronosyltransferase (UGT) 1A1 is the enzyme that detoxifies neurotoxic bilirubin by conjugating it with glucuronic acid. UGT1A1 also plays a critical role in the detoxification and excretion of endogenous and exogenous lipophilic ...
J. Sugatani
semanticscholar   +1 more source

A Major Genotype in UDP-glucuronosyltransferase 2B15

Drug Metabolism and Pharmacokinetics, 2002
A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'.
Toshihiko Fujii, Yoshiki Takahashi, Kenji Toide, Shin-ichiro Umeda, Yoshiaki Terauchi, Hiroshi Yamazaki, Tetsuya Kamataki   +6 more
openaire   +3 more sources

Polymorphisms of UDP-Glucuronosyltransferase and Pharmacokinetics of Irinotecan

Therapeutic Drug Monitoring, 2002
Irinotecan is a prodrug that is hydrolyzed by carboxylesterase in vivo to form an active metabolite SN-38. SN-38 is further conjugated and detoxified by UDP-glucuronosyltransferase (UGT) to yield its beta-glucuronide (SN-38G). Although irinotecan is widely used, the drug causes unpredictably severe, occasionally fatal, toxicity of leukopenia or ...
Hiroshi Ueoka, Yuichi Ando, Masao Ichiki, Yoshinori Hasegawa, Kaoru Shimokata, Toru Sugiyama   +5 more
openaire   +2 more sources

TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1.

Chemical Communications, 2013
TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1.
Takuya Terai, R. Tomiyasu, T. Ota, Tasuku Ueno, Toru Komatsu, K. Hanaoka, Y. Urano, T. Nagano   +7 more
semanticscholar   +1 more source

STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*

Drug Metabolism Reviews, 1999
UDP-Glucuronosyltransferases (UGTs) are glycoproteins localized in the endoplasmic reticulum (ER) which catalyze the conjugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GIcUA) as the sugar donor. Glucuronidation is a major factor in the elimination of lipophilic compounds from the body. In
Anna Radominska-Pandya, Peter I. Mackenzie, Eric Battaglia, Joanna M. Little, Piotr J. Czernik   +4 more
openaire   +3 more sources

Polymorphism of UDP-Glucuronosyltransferase and Drug Metabolism

Current Drug Metabolism, 2005
UDP-glucuronosyltransferase is a group of catabolic enzymes involved in the detoxification and excretion of many xenobiotic and endogeneous substances in intrahepatic and extrahepatic tissues. The group consists of two subfamilies, UGT1 and UGT2. UGT1 consists of 5 exons and has a unique gene structure.
Yoshihiro Maruo, Masaru Iwai, Asami Mori, Hiroshi Sato, Yoshihiro Takeuchi   +4 more
openaire   +3 more sources

The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A

Xenobiotica, 2016
1. The exposed level of vitamin A in plasma might be exceeded due to the both inadvertent and clinical utilization. The adverse effects of vitamin A have been frequently reported, however, the mechanism remains unclear. The inhibition of vitamin A on the activity of UDP-glucuronosyltransferases (UGTs) was determined using in vitro incubation system to ...
Liang-Liang Zhu, Zhenying Zhao, Peipei Dong, Zhi-Wei Fu, Chun-Ting Huang, Hong-Zhi Sun, Zhong-Ze Fang, Yun-Feng Cao, Xue Wu, Xin Liu   +9 more
openaire   +2 more sources