Results 11 to 20 of about 465,354 (232)

Design principles for cyclin K molecular glue degraders

Nature Chemical Biology, 2023
Detailed analysis of the structure–activity relationship for cyclin K degraders reveals diverse compounds that acquire glue activity through simultaneous binding to the CDK12 kinase pocket and engagement of several key DDB1 interfacial residues ...
Zuzanna Kozicka, Dakota J. Suchyta, Vivian Focht, Georg Kempf, Georg Petzold, M. Jentzsch, Charles Zou, C. Di Genua, K. Donovan, Seemon Coomar, Marko Cigler, Cristina Mayor-Ruiz, Jonathan L. Schmid-Burgk, D. Häussinger, Georg E. Winter, E. Fischer, Mikołaj Słabicki, Dennis Gillingham, Benjamin L. Ebert, N. Thomä   +19 more
semanticscholar   +1 more source

GLUE: A Multi-Task Benchmark and Analysis Platform for Natural Language Understanding [PDF]

BlackboxNLP@EMNLP, 2018
Human ability to understand language is general, flexible, and robust. In contrast, most NLU models above the word level are designed for a specific task and struggle with out-of-domain data.
Alex Wang, Amanpreet Singh, Julian Michael, Felix Hill, Omer Levy, Samuel R. Bowman   +5 more
semanticscholar   +1 more source

Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction

RSC Chemical Biology, 2023
Molecular glues are a class of small molecules that stabilize the interactions between proteins. Naturally occurring molecular glues are present in many areas of biology where they serve as central regulators of signaling pathways.
H. Rui, K. Ashton, Jaeki Min, Connie Y. Wang, P. R. Potts   +4 more
semanticscholar   +1 more source

Rational Chemical Design of Molecular Glue Degraders

bioRxiv, 2022
Targeted protein degradation with molecular glue degraders has arisen as a powerful therapeutic modality for eliminating classically undruggable disease-causing proteins through proteasome-mediated degradation.
Ethan S. Toriki, James W. Papatzimas, Kaila Nishikawa, Dustin Dovala, L. McGregor, Matthew J. Hesse, J. McKenna, John A. Tallarico, M. Schirle, Daniel K. Nomura   +9 more
semanticscholar   +1 more source

Molecular glue CELMoD compounds are regulators of cereblon conformation

Science, 2022
Cereblon (CRBN) is a ubiquitin ligase (E3) substrate receptor protein co-opted by CRBN E3 ligase modulatory drug (CELMoD) agents that target therapeutically relevant proteins for degradation.
E. R. Watson, S. Novick, M. Matyskiela, P. Chamberlain, Andres H. de la Peña, Jinyi Zhu, E. Tran, P. Griffin, I. Wertz, G. Lander   +9 more
semanticscholar   +1 more source

Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB

bioRxiv, 2022
Targeted protein degradation using heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) or molecular glues has arisen as a powerful therapeutic modality for degrading disease targets.
E. King, Yoojin Cho, Dustin Dovala, J. McKenna, John A. Tallarico, M. Schirle, Daniel K. Nomura   +6 more
semanticscholar   +1 more source

Haven't got a glue: Protein surface variation for the design of molecular glue degraders.

Cell Chemical Biology, 2021
Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiquitin ligase and a target, which result in ubiquitination and subsequent degradation of the recruited protein.
Zuzanna Kozicka, N. Thomä
semanticscholar   +1 more source

A systematic review and meta-analysis on the use of fibrin glue in peripheral nerve repair: Can we just glue it?

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2022
BACKGROUND Within the field of peripheral nerve surgery, the use of fibrin glue as an alternative to conventional microsurgical suture repair is becoming increasingly popular.
J. E. Koopman, L. Duraku, T. Jong, R. D. de Vries, J. M. Zuidam, C. Hundepool   +5 more
semanticscholar   +1 more source

Endovascular Treatment of a Ruptured Distal Anterior Cerebral Artery Aneurysm Using Coils and N-Butyl-Cyanoacrylate in a 5-Month-Old Baby

Journal of Clinical Interventional Radiology ISVIR, 2021
Intracranial aneurysms in pediatric population are rare and differ in several features with their adult counterpart. Clipping and endovascular therapy have both demonstrated favorable clinical outcomes with reconstructive and deconstructive techniques ...
Giancarlo Saal-Zapata, Jesús Flores, Ricardo Vallejos, Dante Valer, Walter Durand, Rodolfo Rodriguez   +5 more
doaj   +1 more source

Physical and Mechanical Characterization of Fiber Cell Wall in Castor (Ricinus communis L.) Stalk

BioResources, 2014
Castor (Ricinus communis L.) stalk is a byproduct of the production of castor oil. As a natural material, castor stalk has great potential in the production of bio-composites as reinforcement materials.
Xiaoping Li, Guanben Du, Siqun Wang, Guanxia Yu   +3 more
doaj   +1 more source