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Decarboxylases Brain Glutamate Decarboxylase as a Model
1983Decarboxylases are a group of diverse enzymes that catalyze the decarboxylation of amino acids, keto acids, and others. They have been described in bacteria, plants, and animals.1,2 Although some of their functions remain unknown, it is clear that several of the decarboxylases have biosynthetic functions; e.g., ornithine and adenosylmethionine ...
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Regulatory properties of brain glutamate decarboxylase
Cellular and Molecular Neurobiology, 19871. Glutamate decarboxylase is a focal point for controlling gamma-aminobutyric acid (GABA) synthesis in brain. Several factors that appear to be important in the regulation of GABA synthesis have been identified by relating studies of purified glutamate decarboxylase to conditions in vivo. 2. The interaction of glutamate decarboxylase with its cofactor,
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Glutamate decarboxylase. Inhibition by monocarboxylic acids
Archives of Biochemistry and Biophysics, 1972Abstract Aliphatic monocarboxylic acids are demonstrated to be substrate competitive inhibitors of bacterial glutamate decarboxylase. A chain-length effect is observed in the inhibition by the monocarboxylic acids with n -valeric acid functioning as the most effective inhibitor.
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Glutamate Decarboxylase: Preliminary Crystallographic Data
1987Glutamate decarboxylase was purified from Escherichia coli and crystallized by vapour diffusion and microdialysis techniques in the presence of polyethylene glycol. Growth of large crystals suitable for X-ray studies is particularly favoured by low concentrations of citric or glutaric acid, which are both effective inhibitors of the enzyme.
Z. Markovic-Housley +4 more
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GLUTAMIC-ACID DECARBOXYLASE IN SCHIZOPHRENIA
The Lancet, 1978E D, Bird +5 more
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