Results 141 to 150 of about 2,024,212 (329)

Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons

Neural Plasticity, 2016
Glutamate is an important excitatory neurotransmitter in mammalian brains, but excessive amount of glutamate can cause “excitotoxicity” and lead to neuronal death.
Xiaohui Bai, Chi Zhang, Aiping Chen, Wenwen Liu, Jianfeng Li, Qian Sun, Haibo Wang   +6 more
doaj   +1 more source

Neoroprotective effects of tocotrienol-rich fraction and α-tocopherol of vitamin E against glutamate toxicity on astrocyte-neuronal mono-culture and co-culture systems [PDF]

, 2013
Elevated concentration of glutamate, also known as glutamate neurotoxicity, is the major contributor to pathological cell death in nervous system. It has been suggested to play a key role in neurodegenerative diseases.
Yap, Hui Min
core  

Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic Damage

Advanced Science, EarlyView.
SJNPs co‐deliver JHU083 and spermine to reprogram macrophage–neuron immunometabolic crosstalk in sepsis. By suppressing pro‐inflammatory M1 polarization and promoting NGF‐mediated neurotrophic signaling, SJNPs preserve pulmonary neuronal integrity, alleviate lung injury, and improve survival in murine sepsis models.
Wenhui Wang, Yongrui Hai, Xintong Lu, Ye Chen, Bingjie Zhang, Renming Fan, Jiarui Dou, Jiaxin Yan, Shuo Fu, Wen Zhang, Junke Song, Gaofei Wei   +11 more
wiley   +1 more source

Germinated brown rice protects against glutamate toxicity in HT22 hippocampal neurons through the jnk-mediated apoptotic pathway via the GABA_A receptor. [PDF]

IBRO Neurosci Rep, 2023
Promtang S, Turbpaiboon C, Oo EM, Khowawisetsut L, Uawithya P, Chompoopong S.   +5 more
europepmc   +1 more source

Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure. [PDF]

, 2018
Acute exposure to high concentrations of H2S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known.
Anantharam, Poojya, Gearhart, Jeffery M, Grobe, Nadja, Hoffmann, Andrea, Kim, Dong-Suk, Mahama, Belinda, Meade, Mitchell L, Rumbeiha, Wilson K, Whitley, Elizabeth M   +8 more
core  

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Response to amoxicillin and perampanel in infantile Alexander disease

Epilepsia Open
Type I Alexander disease (AxD) presents with paroxysmal neurodegeneration, refractory epilepsy, and encephalopathy in the first years of life and is associated with a poor prognosis.
Susana Boronat, Eulalia Turon‐Viñas, Noel Mac Manus, Asuncion Diaz‐Gomez, Mónica Vicente, Victoria Ros‐Castelló, Alba Sierra‐Marcos   +6 more
doaj   +1 more source

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source

Electrocatalytic C─N Coupling in Aqueous Solutions for High‐Value Product Synthesis

Angewandte Chemie, EarlyView.
Electrocatalytic C–N coupling offers a sustainable route to synthesize crucial organic nitrogen compounds from abundant feedstocks under mild conditions. This review examines recent progress in overcoming key challenges, like slow kinetics and competing reactions through advanced catalysts and novel mechanisms, paving the way for transforming chemical ...
Yunpeng Zuo, Dongxue Yu, Xiaoran Zhang, Xin Wang   +3 more
wiley   +2 more sources

Quercetin ameliorates glutamate toxicity-induced neuronal cell death by controlling calcium-binding protein parvalbumin. [PDF]

J Vet Sci, 2022
Kang JB, Park DJ, Shah MA, Koh PO.
europepmc   +1 more source