Results 261 to 270 of about 2,024,212 (329)

Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons.

Journal of Biochemistry (Tokyo), 2021
Lysophosphatidylethanolamines (LPEs) are bioactive lysophospholipids that have been suggested to play important roles in several biological processes. We performed a quantitative analysis of LPE species and showed their composition in mouse brain.
Kazutoshi Hisano, Hironori Yoshida, S. Kawase, Tetsuhiko Mimura, H. Haniu, T. Tsukahara, Taiga Kurihara, Y. Matsuda, N. Saito, Takeshi Uemura   +9 more
semanticscholar   +1 more source

Neuroprotection from glutamate toxicity with ultra-low dose glutamate

Neuroreport, 2001
The protective effects of ultra-low doses (ULD) of glutamate against glutamate toxicity was studied in primary rat spinal, cortical and cerebellar neurons. Neurons were exposed to four subtoxic, ultra-low concentrations of glutamate (10(-18) M, 10(-20)M, 10(-22) M and 10(-30) M) for 72 h and then subsequently challenged with toxic concentrations (25 ...
W, Jonas, Y, Lin, F, Tortella
openaire   +2 more sources

Glutamate–pyruvate transaminase protects against glutamate toxicity in hippocampal slices

Brain Research, 2003
Elimination of glutamate through enzymatic degradation is an alternative to glutamate receptor blockade in preventing excitotoxic neuronal injury. Glutamate pyruvate transaminase (GPT) is a highly active glutamate degrading enzyme that requires pyruvate as a co-substrate.
C C, Matthews, H R, Zielke, D A, Parks, P S, Fishman   +3 more
openaire   +2 more sources

Glutamate receptor-induced toxicity in neostriatal cells

Brain Research, 1996
Infrared differential interference contrast (IR DIC) videomicroscopy was used to measure and characterize cell swelling induced by activation of glutamate receptors (GluR) in a neostriatal brain slice preparation. This swelling is, in many cases, a prelude to necrotic cell death.
C S, Colwell, M S, Levine
openaire   +2 more sources

Glutamate Toxicity: An Experimental and Theoretical Analysis

European Journal of Neuroscience, 1992
AbstractIn slices of 8‐day‐old rat cerebellum, the lowest concentration of glutamate that induced toxicity (30 min exposure; 90 min recovery) was 100 μM, but the damage only occurred in the outermost regions. As the concentration was raised, the band of necrosis became progressively deeper until, at 3 mM, it was uniform across the slice thickness. At a
Giti, Garthwaite, Geoffrey D., Williams, John, Garthwaite   +2 more
openaire   +2 more sources

Glutamate alleviates cadmium toxicity in rice via suppressing cadmium uptake and translocation.

Journal of Hazardous Materials, 2020
Cadmium (Cd), a naturally occurring heavy metal, is toxic to animals and plants. Minimization of Cd in rice grain is important to human health since rice is the main source of Cd intake for human populations feeding on it as staple food.
Meng Jiang, Jie Jiang, Shan Li, Mei Li, Yuan-yuan Tan, Shi-yong Song, Q. Shu, Jian-zhong Huang   +7 more
semanticscholar   +1 more source

A Non-Excitatory Paradigm of Glutamate Toxicity

Journal of Neurophysiology, 2002
Retinal ganglion cells are driven by glutamatergic synapses, but they are also very susceptible to glutamate toxicity. Whereas the conventional excitotoxicity model of glutamate-induced cell death requires membrane depolarization, we have found that glutamate toxicity need not be linked with excitation.
Wen, Shen, Malcolm M, Slaughter
openaire   +2 more sources

Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro‐2a cells from glutamate toxicity

Life Science, 2018
Aim: Glutamate is a major neurotransmitter involved in several brain functions and glutamate excitotoxicity is involved in Alzheimer's disease (AD). In the current study, the neuroprotective effect of the Indian medicinal plant Grewia tiliaefolia (GT ...
D. Malar, M. Prasanth, Rajamohamed Beema Shafreen, K. Balamurugan, K. P. Devi   +4 more
semanticscholar   +1 more source

Metabotropic Glutamate Receptors and Neuronal Toxicity

1992
Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G, PISANI A, COPANI A, BRUNO V, ARONICA E, D'AGATA V, CANONICO P. L, NICOLETTI F   +7 more
openaire   +6 more sources

L-Glutamate toxicity in Huntington's Disease fibroblasts

Biochemical and Biophysical Research Communications, 1980
Abstract Brain degeneration in Huntington's Disease is thought to occur primarily in the regions of high L-glutamate concentrations. Huntington's Disease fibroblast cultures have a sensitivity to these high concentrations of L-glutamate. These cells show degeneration and loss of viability, within 12 hrs, following treatment with 30 mM L-glutamate ...
P N, Gray, P C, May, L, Mundy, J, Elkins
openaire   +2 more sources