Results 271 to 280 of about 2,024,212 (329)

Management of monosodium glutamate toxicity

Journal of Asthma, 1982
(1982). Management of monosodium glutamate toxicity. Journal of Asthma: Vol. 19, No. 2, pp. 105-110.
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Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents

Developmental Brain Research, 1990
Cationic fluxes resulting from glutamate receptor activity have recently been implicated in neurotoxicity. Immature cortical neurons are insensitive to the toxic effects of glutamate receptor stimulation. However, these neurons are killed by glutamate via a non-receptor-mediated mechanism thought to stem from glutamate's ability to inhibit cystine ...
T H, Murphy, J M, Baraban
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Heat shock protects cultured neurons from glutamate toxicity

Neuron, 1991
Expression of heat shock proteins (HSPs) occurs in brain after ischemia and status epilepticus. We report that induction of the heat shock response in cortical cultures protects neurons from glutamate-induced excitotoxicity. Cultures heated to 42.2 degrees C for 20 min showed an overall decrease in protein synthesis but an increase in the synthesis of ...
G, Rordorf, W J, Koroshetz, J V, Bonventre   +2 more
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Estrogen protects primary cortical neurons from glutamate toxicity

Neuroscience Letters, 1996
The gonadal steroid estrogen has been shown to affect neuronal growth, differentiation and survival. We examined the ability of estrogen to protect primary cortical neurons from toxicity induced by the excitatory neurotransmitter glutamate. In these experiments, a 24-h pretreatment with 15 and 50 nM 17 beta-estradiol significantly reduced cellular ...
C A, Singer, K L, Rogers, T M, Strickland, D M, Dorsa   +3 more
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Chronic glutamate toxicity in mouse cortical neuron culture

Brain Research, 2009
Two pathways for glutamate toxicity have been described, receptor-mediated excitotoxicity and non-receptor mediated oxidative glutamate toxicity. Here, we show that two distinct forms of receptor-mediated primary cortical neuronal death exist, chronic and acute glutamate toxicity, and that these depend on exposure time.
Jong Seong, Ha, Chul-Sang, Lee, Jin-Soo, Maeng, Ki-Sun, Kwon, Sung Sup, Park   +4 more
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Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity

Brain Research, 2010
Oxidative glutamate toxicity is characterized by the inhibition of cystine uptake, the depletion of intracellular glutathione, and increased levels of intracellular reactive oxygen species, factors that lead to neuronal injury. We found that the presence of extracellular catalase protected cultured neuronal cells, such as HT22, SH-SY5Y and PC12 cells ...
Jong Seong, Ha, Heon M, Lim, Sung Sup, Park   +2 more
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Scutellarin Attenuates Oxidative Glutamate Toxicity in PC12 Cells

Planta Medica, 2004
The present study investigated the protective effects of the antioxidant scutellarin against oxidative toxicity induced by glutamate in PC12 cells. Vitamin E, a classical antioxidant was employed as a comparative agent. Incubation of PC12 cells with 10 mM glutamate resulted in significant cytotoxity as evaluated by the MTT and lactate dehydrogenase ...
Hao, Hong, Guo-Qing, Liu
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Acetoacetate protects neuronal cells from oxidative glutamate toxicity

Journal of Neuroscience Research, 2006
Glutamate cytotoxicity contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as epilepsy and ischemia. We previously reported that a high-fat and low-carbohydrate diet, the ketogenic diet (KD), protects against kainic acid-induced hippocampal cell death in mice.
Hae Sook, Noh, Young-Sool, Hah, Rashidova, Nilufar, Jaehee, Han, Jae-Hwan, Bong, Sang Soo, Kang, Gyeong Jae, Cho, Wan Sung, Choi   +7 more
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The toxicity of monosodium glutamate in young rats

Biochimica et Biophysica Acta (BBA) - General Subjects, 1971
Abstract Intraperitoneal or intragastric injection of monosodium l -glutamate (4 mg/g) to infant rats invariably caused an increase in brain glutamine, never in brain glutamate. The toxicity (convulsions) observed after these doses was not unique to l -glutamate; monosodium l -aspartate or d -glutamate gave similar symptoms.
I K, Mushahwar, R E, Koeppe
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Analysis of glutamate uptake and monosodium glutamate toxicity in neural retina monolayer cultures

Developmental Brain Research, 1981
Abstract Three different types of monolayer cultures from 8-day chick embryo neural retina can be generated by differential manipulation of culture media and substrata. They are: (i) a purified monolayer of neurons; (ii) a purified monolayer of nonneuronal, flat cells; and (iii) complex cultures containing both neurons and nonneurons ...
A G, Hyndman, R, Adler
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