Results 281 to 290 of about 2,024,212 (329)

Serotonin protects C6 glioma cells from glutamate toxicity

Neuroscience, 1994
It was recently shown that addition of L-glutamate in millimolar amounts to a culture of C6 glioma cells induced cell death within 24 h. The mechanism for glutamate toxicity in the C6 glioma cells is linked to the inhibition of cystine uptake, leading to glutathione depletion through the cystine/glutamate antiporter (Xc) system.
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Calcium dynamics in neurons treated with toxic and non-toxic concentrations of glutamate

NeuroReport, 1992
Intracellular calcium concentration ([Ca2+]i) dynamics were simultaneously monitored in multiple cultured rat neurons loaded with Fluo-3 and continuously stimulated with glutamate (GLU). Three response types were observed: 10 microM GLU caused an initial transient increase in [Ca2+]i; 20 microM a biphasic response characterized by a 150-350 s 'calcium ...
M A, DeCoster, M L, Koenig, J C, Hunter, F C, Tortella   +3 more
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Cullin5 Reduces Retinal Cell Death Induced by Glutamate Toxicity

Current Eye Research, 2010
To investigate the expression in the mouse retina and the function in a retinal cell of cullin5 that is known as a protein that is associated with ubiquitilation.The retinal sites of expressing cullin5 were determined by immunohistochemistry with a specific antibody for cullin5.
Takashi, Kanamoto, Hideaki, Okumichi, Ulfah, Rimayanti, Yoshiaki, Kiuchi   +3 more
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Glutamic acid modification of vincristine toxicity.

Cancer biochemistry biophysics, 1984
The principal limiting feature of the antitumor agent, vincristine, in the clinic has been neurotoxicity; there are no known agents which can routinely prevent or decrease this side effect. Glutamic acid in laboratory and clinical investigations in the early 1960s was found to antagonize vinblastine, another clinically useful vinca alkaloid.
D V, Jackson, D L, Rosenbaum, L J, Carlisle, T R, Long, H B, Wells, C L, Spurr   +5 more
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Cystine Protects Cochlear Outer Hair Cells against Glutamate Toxicity

Acta Oto-Laryngologica, 1999
We previously reported that long-term exposure to glutamate (Glu) induced death of cochlear outer hair cells (OHCs). However, the mechanisms of OHC death induced by Glu were unclear. In the central nervous system, Glu is known to interfere with a cystine-Glu antiporter, leading to a decrease in cystine uptake and reducing the intracellular glutathione ...
K, Sunami, H, Yamane, M, Takayama, T, Nakagawa, K, Konishi, H, Iguchi   +5 more
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BCL-2 blocks glutamate toxicity in neural cell lines

Molecular Brain Research, 1993
Glutamate has been shown, at high concentrations (5-10 mM), to lead to death in cells of the pheochromocytoma cell line PC12. We report that similar concentrations of glutamate also kill immortalized central neural cell lines, and that the expression of the proto-oncogene bcl-2 in these cell lines blocks glutamate neurotoxicity.
L T, Zhong, D J, Kane, D E, Bredesen
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Manganese Toxicity and the Glutamine–Glutamate Cycle

2014
Glutamine (Gln) is abundantly expressed in the central nervous system (CNS), where it participates in a variety of metabolic pathways. Gln metabolism proceeds via the glutamine/glutamate (Glu)-γ-aminobutyric acid (GABA) cycle (GGC), and the reactions within this cycle are carried out both in astrocytic and neuronal compartments. The GGC appears to have
Marta Sidoryk-Wegrzynowicz, Michael Aschner   +1 more
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NAALADase inhibition protects motor neurons against chronic glutamate toxicity

European Journal of Pharmacology, 2003
Glutamate toxicity is implicated in the pathogenesis of amyotrophic lateral sclerosis. The neuropeptide N-acetyl-aspartyl glutamate (NAAG) appears to function both as a storage form for glutamate and as a neuromodulator at glutamatergic synapses. N-acetylated-alpha-linked acidic dipeptidase (NAALADase; also termed glutamate carboxypeptidase II) yields ...
Ajit G, Thomas, Andrea M, Corse, Carol F, Coccia, Masako M, Bilak, Jeffrey D, Rothstein, Barbara S, Slusher   +5 more
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Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro

Neuroscience Letters, 2000
Non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of Alzheimer's disease, although the underlying mechanisms are unknown. Glutamate excitotoxicity has been implicated in Alzheimer's disease, Parkinson's disease, and others. We examined the effects of aspirin, acetaminophen, and ibuprofen on cultured primary rat embryonic neurons from ...
D, Casper, U, Yaparpalvi, N, Rempel, P, Werner   +3 more
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Glutamate toxicity enhances tau gene expression in neuronal cultures

Journal of Neuroscience Research, 1997
Tau protein is a microtubule-associated protein normally expressed in neurons. In Alzheimer's disease (AD) brains, phosphorylated tau accumulates in paired helical filaments which form neurofibrillary tangles in affected neurons; moreover, tau mRNA expression is increased in affected regions of AD brains.
F, Esclaire, M, Lesort, C, Blanchard, J, Hugon   +3 more
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