Results 291 to 300 of about 2,024,212 (329)

Protective autoimmunity against the enemy within: fighting glutamate toxicity

Trends in Neurosciences, 2003
Glutamate, a key neurotransmitter, is pivotal to CNS function. Alterations in its concentration can be dangerous, as seen for example in acute injuries of the CNS, chronic neurodegenerative disorders and mental disorders. Its homeostasis is attributed to the efficient removal of glutamate from the extracellular milieu by reuptake via local transport ...
Michal, Schwartz, Iftach, Shaked, Jasmin, Fisher, Tal, Mizrahi, Hadas, Schori   +4 more
openaire   +2 more sources

Protection by prostaglandins from glutamate toxicity in cortical neurons☆

Neurochemistry International, 1994
The growing evidence that glutamate may be an important agent mediating ischemic damage to neurons, led us to investigate the possible protective effects of pharmacological agents against glutamate in a model system of cortical neurons. In this study we examined, in particular, the cytoprotective effect of prostaglandins.
C, Cazevieille, A, Muller, F, Meynier, N, Dutrait, C, Bonne   +4 more
openaire   +2 more sources

Urolithin B protects PC12 cells against glutamate-induced toxicity

Molecular Biology Reports
The involvement of malfunctioning glutamate systems in various central nervous system (CNS) disorders is widely acknowledged. Urolithin B, known for its neuroprotective and antioxidant properties, has shown potential as a therapeutic agent for these disorders.
Israa, Aljabouri, Mehdi, Rostami, Farshad, Mirzavi, Mahla Kazemian, Kakhki, Abbas, Alalikhan, Elaheh, Gheybi, Ali, Hakimi, Mohammad, Soukhtanloo   +7 more
openaire   +2 more sources

Glutamate Toxicity in Lung and Airway Disease

2007
1. Experimental glutamate toxicity can occur in the respiratory system. Acute administration of high concentrations of glutamate or glutamate agonist NMDA can elicit high-permeability pulmonary edema and airway constriction. 2. Endogenous glutamate receptor activation may play a key role in mediating oxidant lung injury, and airway hyper-
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Atorvastatin and Fluoxetine Prevent Oxidative Stress and Mitochondrial Dysfunction Evoked by Glutamate Toxicity in Hippocampal Slices

Molecular Neurobiology, 2017
F. K. Ludka, Tharine A. Dal-Cim, L. B. Binder, L. Constantino, C. Massari, C. Tasca   +5 more
semanticscholar   +1 more source

Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities.

Lancet Neurology, 2016
Richard Macrez, P. Stys, D. Vivien, S. Lipton, F. Docagne   +4 more
semanticscholar   +1 more source

Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway

Cellular and molecular neurobiology, 2016
Xiaoyuan Mao, Honghao Zhou, Xi Li, Zhaoqian Liu   +3 more
semanticscholar   +1 more source

More dimensions for glutamate toxicity

Science, 1988
openaire   +1 more source

Increased Expression of GM1 Detected by Electrospray Mass Spectrometry in Rat Primary Embryonic Cortical Neurons Exposed to Glutamate Toxicity.

Analytical Chemistry, 2016
D. Park, Lynn Wang, Paula Pittock, G. Lajoie, S. Whitehead   +4 more
semanticscholar   +1 more source