Results 131 to 140 of about 9,046 (297)

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Reduction of sodium content in baking through new technological approaches

Journal of Engineering Science (Chişinău)
Excessive sodium consumption is a global public health concern, negatively impacting life expectancy and overall quality of life. Bread, one of the world’s staple foods, contributes significantly to total sodium consumption, making it ...
CARACACI, Corina, CODINĂ, Georgiana Gabriela, GHENDOV-MOSANU, Aliona   +2 more
doaj   +1 more source

Thermoresponsive Polypeptides from Pegylated Poly-l-glutamates

, 2016
The synthesis and characterization of new thermoresponsive pegylated poly-l-glutamate (poly-l-EGxGlu) are described. The obtained polypeptides display low critical solution temperature (LCST) behaviors in water, and the LCST can be tuned via ...
Zhibo Li (1328010), Chongyi Chen (1859107), Zhaohui Wang (144332)   +2 more
core   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Characterization of a second class Ie ribonucleotide reductase

Communications Biology
Class I ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides under oxic conditions. The R2 subunit provides a radical required for catalysis conducted by the R1 subunit. In most R2s the radical is generated on a tyrosine via
Juliane John, Daniel Lundin, Rui M. Branca, Rohit Kumar, Vivek Srinivas, Hugo Lebrette, Martin Högbom   +6 more
doaj   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Nitric Oxide Reductase from Paracoccus denitrificans [Elektronisk resurs] : A Proton Transfer Pathway from the “Wrong” Side

, 2008
Denitrification is an anaerobic process performed by several soil bacteria as an alternative to aerobic respiration. A key-step in denitrification (the N-N-bond is made) is catalyzed by nitric oxide reductase (NOR); 2NO + 2e- + 2H+ → N2O + H2O.
Flock, Ulrika,, de Vries, Simon,, Ädelroth, Pia,   +2 more
core  

A family of protein-deglutamylating enzymes associated with neurodegeneration.

, 2010
International audiencePolyglutamylation is a posttranslational modification that generates glutamate side chains on tubulins and other proteins. Although this modification has been shown to be reversible, little is known about the enzymes catalyzing ...
Annie Andrieux, Magiera, Maria, M., Deloulme, Jean-Christophe, Grau, Montserrat Bosch, Desagher, S., Gold, Nicholas, D., Nicholas D. Gold, Janke, C., Montserrat Bosch Grau, Bosson, A., Rogowski, Krzysztof, Bosc, C., Holzer, Max, Lacroix, B., Anouk Bosson, Grau, M. B., Rogowski, K., Peris, Leticia, Moutin, M. J., Magiera, M. M., Solange Desagher, Jean-Christophe Deloulme, Christian Larroque, Christophe Bosc, Benjamin Lacroix, Max Holzer, Dijk, J.,, Lacroix, Benjamin, Desagher, Solange, Nicole Bec, Deloulme, J. C., Bec, N., Leticia Peris, Janke, Carsten, Andrieux, A., Magiera, Maria M., Gold, N. D., Bosson, Anouk, Andrieux, Annie, Krzysztof Rogowski, Bosc, Christophe, Gold, Nicholas D., Juliette van Dijk, Marie-Jo Moutin, Bec, Nicole, Larroque, C., Peris, L., Holzer, M., Larroque, Christian, Magiera, Maria,, Moutin, Marie-Jo, Gold, Nicholas,, Maria M. Magiera, van Dijk, Juliette, Carsten Janke   +54 more
core   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source