Shifting the Substrate Scope of an Ene/Yne‐Reductase by Loop Engineering
ChemCatChem, EarlyView.A flexible active‐site loop that is involved in shaping the substrate and product cleft as well as the active‐site pocket was identified for the MDR‐related ene/yne‐reductase CaeEnR1 from Cyclocybe aegerita. Double mutations of this loop showed an up to 20‐fold increase in conversion rates toward cinnamaldehyde‐like substrates and a 2‐fold increase in ...
Dominik Karrer +7 more
wiley +1 more source
Enzyme Activation in Wheat Grains in Relation to Water Content. Glutamic Acid—Alanine Transaminase, and Glutamic Acid Decarboxylase. [PDF]
, 1959 P. Linko, Max Milner
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GLUTAMIC ACID DECARBOXYLASE IN BRAIN [PDF]
Journal of Biological Chemistry, 1951 Eugene Roberts, Sam Frankel
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Merging Peptide and Enzyme Catalysis in a Single Protein Domain Bearing Two Separated Active Sites
ChemCatChem, EarlyView.A dual‐functional catalyst that unites peptide catalysis and biocatalysis within a single protein scaffold at two distinct active sites offers a promising strategy for cascade catalysis. This hybrid catalyst enabled here a one‐pot transformation of alcohols to C─C coupled products via enamine activation, revealing challenges such as mismatched reaction
Mathias Pickl +7 more
wiley +1 more source
DETERMINATION OF ASPARTIC AND GLUTAMIC ACIDS BY ENZYMATIC DECARBOXYLATION
, 1951 Alton Meister +2 more
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The Ascent of Supramolecular Polymers and Gels in Asymmetric Catalysis
Chemistry – A European Journal, EarlyView.SPs and gels emerged as modular platforms for asymmetric catalysis. This review ranks literature reports according to the achiral or chiral nature of the monomers bearing the catalytic site. New paradigms showcased by this approach are particularly highlighted, such as catalysts operating with a low amount of chiral inducers, or with no chiral inducer,
Ran Chen +2 more
wiley +1 more source
MECHANISM OF THE CONVERSION OF ORNITHINE INTO PROLINE AND GLUTAMIC ACID IN VIVO
, 1951 Marjorie R. Stetten
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The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability
Cytoskeleton, EarlyView.ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou +6 more
wiley +1 more source
The estimation of
, 1953 G. H. Wiltshire
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A GLUTAMIC ACID-PRODUCING BACILLUS [PDF]
Journal of Bacteriology, 1959 J. W. Foster, Kwei-Chao Chao
openaire +3 more sources