Results 301 to 310 of about 278,769 (333)
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Bicyclic glutamic acid derivatives
Chirality, 2006AbstractFor the second‐generation asymmetric synthesis of the trans‐tris(homoglutamic) acids via Strecker reaction of chiral ketimines, the cyanide addition as the key stereodifferentiating step produces mixtures of diastereomeric α‐amino nitrile esters the composition of which is independent of the reaction temperature and the type of the solvent ...
Meyer, U. +3 more
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Glutamic acid and ethanol dependence
Pharmacology Biochemistry and Behavior, 1978Glutamate diethyl ester, a specific glutamate antagonist, attenuated the seizures and decreases in behavioral activity that were observed in mice during withdrawal. Prior to withdrawal, ethanol-dependent animals were supersensitive to kainic acid, a potent glutamate agonist, but they were not supersensitive to the convulsant drug pentylenetetrazol ...
Elias K. Michaelis, William J. Freed
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PERMANENCY OF GLUTAMIC ACID TREATMENT
Archives of Neurology And Psychiatry, 1951OUR PREVIOUS publications have been concerned with the effect of glutamic acid on mental functioning at various levels of the learning curve and over different intervals of time. 1 Glutamic acid was found to be beneficial not only to patients in the category of low-defective intelligence, but to persons at the high-defective and borderline intelligence
Bessie B. Burgemeister +1 more
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GLUTAMIC ACID AND INTELLIGENCE
Journal of the American Medical Association, 1949To the Editor:— I read with a great deal of interest the editorial inThe Journal, Dec. 25, 1948, page 1231, on the subject "Glutamic Acid and Intelligence." Any therapeutic measure which would offer even a glimmer of promise in helping the mentally retarded would indeed be a blessing.
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Experimental Brain Research, 1988
The actions of the four isomers of 1-amino-1, 3-cyclopentane dicarboxylate (ACPD), a conformationally restricted analogue of glutamate, have been examined for their ability to displace radiolabelled kainate and glutamate from their binding sites on membranes prepared from rat brain.
K. Curry, H. McLennan
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The actions of the four isomers of 1-amino-1, 3-cyclopentane dicarboxylate (ACPD), a conformationally restricted analogue of glutamate, have been examined for their ability to displace radiolabelled kainate and glutamate from their binding sites on membranes prepared from rat brain.
K. Curry, H. McLennan
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Glutamate Dehydrogenase Reaction as a Source of Glutamic Acid in Synaptosomes
Journal of Neurochemistry, 1991Abstract: The role of the glutamate dehydrogenase reaction as a pathway of glutamate synthesis was studied by incubating synaptosomes with 5 mM15NH4Cl and then utilizing gas chromatography‐mass spectrometry to measure isotopic enrichment in glutamate and aspartate.
Zhi-Ping Lin +4 more
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Effect of phosphonic analogues of glutamic acid on glutamate decarboxylase
Experientia, 1985Among the phosphonic analogues of glutamic acid, only 4-amino-4-phosphono butyric acid, the compound which shows the highest affinity for pyridoxal phosphate, inhibits competitively both Escherichia coli and rat brain glutamate decarboxylases. Phosphinothricin, 2-amino-4-(methylphosphino)butyric acid, is a strong inhibitor of the mammalian enzyme.
Eugène Neuzil +3 more
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Experimental Neurology, 1988
The fine distribution of GABA, glutamic acid decarboxylase, and glutamic acid within each layer of the rabbit cerebellar cortex was determined with microanalytical methods. The greatest glutamic acid decarboxylase activity and the highest GABA concentration were found in the Purkinje cell layer.
Yasuhiro Okada, Sanae Kanno
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The fine distribution of GABA, glutamic acid decarboxylase, and glutamic acid within each layer of the rabbit cerebellar cortex was determined with microanalytical methods. The greatest glutamic acid decarboxylase activity and the highest GABA concentration were found in the Purkinje cell layer.
Yasuhiro Okada, Sanae Kanno
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Glutamic Acid and Cerebral Function
1951Publisher Summary The role of glutamic acid in cerebral metabolism is traced to the study of the effects of the administration of the amino acid to patients suffering from petit ma1 epilepsy and to mentally defective subjects. This chapter exclusively deals with the data on humans as they bear on the biochemistry of glutamic acid. Glucose is the main
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From Glycine to Glutamic Acid: Analysis of the Proton-Binding Isotherm of Glutamic Acid
Analytical Biochemistry, 1998The process of the analysis of the protonation of glycine is extended to the three-site molecule of glutamic acid with its amino and two carboxyl groups. Detailed data on the binding of protons to glutamic acid are available not only for protonation of the three groups simultaneously but also for derivatives in which the alpha and beta carboxyl groups ...
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