Results 231 to 240 of about 24,633 (278)
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Glutaminase Activity and Neocortical Excitability
Nature, 1965THE work recorded here was carried out in order to ascertain whether glutaminase I activity in the neocortex of the cat plays a part in the glutamate-glutamine system changes induced by the appearance and development of an epileptogenic focus produced by application of mescaline1.
N, Mison-Crighel +2 more
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The role of glutaminase in the small intestine
The International Journal of Biochemistry & Cell Biology, 1999Glutaminase is the enzyme which hydrolyses glutamine, the main respiratory fuel of the intestine, to yield glutamate and ammonia. Glutaminase has a central role in intestinal metabolism: the products of the reaction catalyzed by glutaminase can be transaminated, catabolized to yield energy or used for the biosynthesis of pyrimidine nucleotides ...
R, McCauley +3 more
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Hepatic glutaminase expression: relationship to kidney‐type glutaminase and to the urea cycle
The FASEB Journal, 1993Glutamine functions as a major transport form of nitrogen and carbon within the body. In the liver, glutamine is hydrolyzed by a unique liver‐type, phosphate‐activated glutaminase, and the end products of hepatic glutamine catabolism are glucose and urea. Other tissues possess a different, kidney‐type, glutaminase isozyme.
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The activity of glutaminase in the human placenta
Archives of Biochemistry and Biophysics, 1951Abstract Homogenates and extracts of human placenta are able to desamidate glutamine by means of an enzyme which has the properties of glutaminase. Placental glutaminase is activated by phosphate. Its pH optimum lies at 9.0. A method for its assay in placental homogenate is described.
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Safety evaluation of yeast glutaminase
Food and Chemical Toxicology, 2000The consumption of soy and soy products (including soy sauce) has been increasing in Western countries due to purported health benefits of soy (cancer protective, estrogenic effects). In addition to providing soy proteins and isoflavones, soy sauce also functions as a flavor enhancer and is able to impart a "umami" taste.
K, Ohshita +5 more
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On glutaminase activity in mammalian synaptosomes
Brain Research, 1976A large proportion (30%) of tissue glutaminase activity was found localized in synaptosome fractions as well as purified mitochondrial fractions, where it is also enriched on a protein basis (2-fold). Sulphate was more effective (2-8-fold) than phosphate or chloride in activating the enzyme at concentrations above 10-12 mM, but equivalent to phosphate ...
H F, Bradford, H K, Ward
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LOCALIZATION OF GLUTAMINASE IN THE RAT NEOSTRIATUM
Journal of Neurochemistry, 1979Abstract— Glutaminase activity in rat striatal tissue was not significantly decreased by lesions of the cortico‐striatal tract which depressed striatal glutamate uptake by 47% but was markedly decreased following intrastriatal injections of kainic acid.
E G, McGeer, P L, McGeer
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Glutaminase inhibitors: a patent review
Expert Opinion on Therapeutic Patents, 2018The kidney-type glutaminase (GLS) controlling the first step of glutamine metabolism is overexpressed in many cancer cells. Targeting inhibition of GLS shows obvious inhibitory effects on cancer cell proliferation. Therefore, extensive research and development of GLS inhibitors have been carried out in industrial and academic institutions over the past
CanRong, Wu +3 more
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Glutaminase isozymes in rat kidney
Biochemical and Biophysical Research Communications, 1966Abstract In 1958 Sayer and Roberts reported on the mode of activation of glutaminase by phosphate using a dog kidney preparation. More recently Kvamme et al. (1965) showed that the activation by phosphate involves a conformational change of the enzyme protein of pig kidney. The authors found that there are two types of glutaminase in rat kidney.
N, Katunuma, I, Tomino, H, Nishino
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