Results 221 to 230 of about 216,468 (357)

Tumor desialylation surpasses anti‐PD‐L1 checkpoint therapy in restoring anti‐tumor immunity in a murine model for colorectal cancer

International Journal of Cancer, Volume 157, Issue 9, Page 1948-1962, 1 November 2025.
What's new? Our research highlights how tumor sialylation affects tumor growth and reshapes the immune tumor microenvironment in colorectal cancer. We demonstrate for the first time that complete removal of sialic acids from colorectal tumor cells elicits a robust anti‐tumor immune response, but does not enhance anti‐PD‐L1 blockade efficacy.
Irene van der Haar Àvila, Tao Zhang, Victor Lorrain, Eelco Keuning, Laraib Amir Ali, Cora Chadick, Sara García‐García, Louis Boon, Noortje de Haan, Juan J. García‐Vallejo, Yvette van Kooyk, Sandra J. van Vliet   +11 more
wiley   +1 more source

Glutamine Synthetase: Diverse Regulation and Functions of an Ancient Enzyme. [PDF]

Biochemistry
Tecson MCB, Geluz C, Cruz Y, Greene ER.
europepmc   +1 more source

Bestrophin-2 and glutamine synthetase form a complex for glutamate release. [PDF]

Nature, 2022
Owji AP, Yu K, Kittredge A, Wang J, Zhang Y, Yang T.   +5 more
europepmc   +1 more source

A COMPARISON OF THE CHARACTERISTICS OF GLUTAMINE SYNTHETASE AND GLUTAMATE DEHYDROGENASE FROM LEMNA MINOR L. [PDF]

, 1977
George R. Stewart, David Rhodes
openalex   +1 more source

The Evolving Trend of Liver Transplantation in Metabolic Diseases: From Origins to Current Perspectives

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Liver transplantation (LTx) has become, over the years, an increasingly used therapeutic option in patients with inherited metabolic diseases (IMD). Initially performed for Tyrosinemia Type I and ornithine transcarbamylase deficiency, it now accounts as the second indication for pediatric transplants worldwide. The use of LTx has been extended
Andrea Pietrobattista, Diego Martinelli, Marco Spada, Carlo Dionisi‐Vici   +3 more
wiley   +1 more source

Characterization of the Glutamine Synthetase Gene Family in Wheat (<i>Triticum aestivum</i> L.) and Expression Analysis in Response to Various Abiotic Stresses. [PDF]

Int J Mol Sci
Zhang Z, Zhang X, Mu Y, Wang H, Wang L, Nai F, Wei Y, Xiong S, Ma X, Li H, Wang X.   +10 more
europepmc   +1 more source

Critical Evaluation of the Changes in Glutamine Synthetase Activity in Models of Cerebral Stroke

Neurochemical Research, 2015
T. Jeitner, K. Battaile, Arthur J. L. Cooper   +2 more
semanticscholar   +1 more source

A Deep Clinical and Biochemical Characterization of a Patient With Combined Malonic and Methylmalonic Aciduria (CMAMMA)

JIMD Reports, Volume 66, Issue 6, November 2025.
ABSTRACT Combined malonic and methylmalonic aciduria (CMAMMA) is an inborn error of metabolism caused by a deficiency in mitochondrial malonyl‐CoA synthetase, the enzyme responsible for activating malonic acid (MA) to malonyl‐CoA, a precursor of lipoic acid.
Vincenza Gragnaniello, Alfonso Galderisi, Sara Tucci, Mara Doimo, Marianna Caterino, Christian Loro, Chiara Cazzorla, Margherita Ruoppolo, Leonardo Salviati, Alberto B. Burlina   +9 more
wiley   +1 more source

2-oxoglutarate triggers assembly of active dodecameric <i>Methanosarcina mazei</i> glutamine synthetase. [PDF]

Elife
Herdering E, Reif-Trauttmansdorff T, Kumar A, Habenicht T, Hochberg G, Bohn S, Schuller J, Schmitz RA.   +7 more
europepmc   +1 more source

Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway. [PDF]

Int J Med Sci, 2023
Xuan DTM, Wu CC, Wang WJ, Hsu HP, Ta HDK, Anuraga G, Chiao CC, Wang CY.   +7 more
europepmc   +1 more source