Results 241 to 250 of about 91,004 (324)

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry   +13 more
wiley   +1 more source

Biomolecular Interaction, Molecular Docking, Antimicrobial, Antioxidant, Antitumor, Cell Cycle Analysis, and Annexin V/PI Assay Efficiency of Some Co (II), Cu (II), Mn (II), Ni (II), Pd (II), and Pt (II) Complexes With a Halogenated Bidentate Schiff Base

open access: yesApplied Organometallic Chemistry, Volume 39, Issue 12, December 2025.
The ligand and metal complexes have been characterized experimentally and theoretically. Molecular docking studies were performed. The binding affinity toward biomolecules was analyzed. The in vitro antimicrobial (bacteria and fungi) behavior was evaluated. Furthermore, radical scavenging and in vitro anticancer activity, apoptosis, and cell cycle were
Elena Pahonțu   +13 more
wiley   +1 more source

Specific promoters for genetic engineering of the rubber tree; molecular and functional analysis : [Draft] [PDF]

open access: yes, 2004
Cambillau, Laurence   +7 more
core  

From Gene to Enzyme: Multidimensional Decoding of the GGT Molecular Family and Its Clinical Tumor Diagnosis

open access: yesCancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Gamma‐glutamyltransferase (GGT) is a membrane‐bound enzyme involved in glutathione metabolism and oxidative stress regulation. Although it is traditionally viewed as a liver function marker, emerging evidence suggests that its aberrant expression is closely associated with tumorigenesis, progression, and therapeutic resistance ...
Fei Wang   +11 more
wiley   +1 more source

Herbicide programs for control of a five‐way herbicide resistant waterhemp population in Xtendflex or Enlist E3 soybean

open access: yesCrop, Forage &Turfgrass Management, Volume 11, Issue 2, December 2025.
Abstract Waterhemp [Amaranthus tuberculatus (Moq.) J.D. Sauer] is one of the most problematic weeds in soybean [Glycine max (L.) Merr.] production in the Midwestern United States. In recent years, the adoption of soybean resistant to dicamba, 2,4‐D, and/or glufosinate have enabled the use of these herbicides to improve control of problematic weeds ...
Claudia R. Bland   +3 more
wiley   +1 more source

From Leaf to Brew: Comprehensive Insights Into the Physiology, Processing, and Flavor of Nanchuan Tea (Camellia nanchuanica)

open access: yesFood Chemistry International, Volume 1, Issue 4, Page 375-383, December 2025.
Nanchuan tea: a novel tea resource with a unique flavor profile. ABSTRACT Camellia nanchuanica, a unique tea species endemic to the mountainous regions of Nanchuan (Chongqing, China), represents a valuable germplasm resource with distinctive flavor characteristics and physiological adaptations.
Yan Liu, Liyong Luo, Liang Zeng
wiley   +1 more source

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