Results 251 to 260 of about 216,468 (357)

Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen   +14 more
wiley   +1 more source

Rat Liver Glutamine Synthetase

open access: hybrid, 1972
Suresh S. Tate   +2 more
openalex   +1 more source

Differential impact of manganese on glutamate clearance, electroencephalography, and sleep in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Underlying glutamate dysregulation in Alzheimer's disease can be worsened by environmental factors like manganese (Mn) exposure. This study examined how excess Mn affects glutamatergic signaling and neurotransmission in a beta‐amyloid mouse model. METHODS APP/PSEN1 and control mice were exposed to systemic Mn subcutaneously.
Rebecca A. Buchanan   +5 more
wiley   +1 more source

Addendum to “Reconstruction of glutamine synthetase using computer averaging” [PDF]

open access: green, 1979
Joachim Frank   +3 more
openalex   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

open access: yesCancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu   +16 more
wiley   +1 more source

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