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Activity of the nitrate reductase and glutamine synthetase enzymes in arabic coffee.
, 2005 José Fernandes de Andrade Netto
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Glutamine synthetase and hepatocellular carcinoma
Clinics and Research in Hepatology and Gastroenterology, 2023Glutamine synthetase (GS) is an enzyme that converts ammonia and glutamate to glutamine using adenosine triphosphate. GS is expressed in the brain, kidney, and liver tissues under normal physiological conditions. GS is involved in abnormal lipid metabolism of the liver by catalyzing de novo synthesis of glutamine, thereby inducing liver inflammation ...
Jinghua, Jiang +3 more
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Glutamine synthetase deadenylylating enzyme
Biochemical and Biophysical Research Communications, 1968The glutamine synthetase of Escherichiacoli exists in various forms differing from each other by their content of covalently bound adenylyl groups (Shapiro etal., 1967;Wulff etal., 1967). The biosynthetic activity of unadenylylated glutamine synthetase is very much greater with Mg2+ as the activating cation than with Mn2+, and its γ-glutamyl ...
B M, Shapiro, E R, Stadtman
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Congenital Glutamine Deficiency with Glutamine Synthetase Mutations
New England Journal of Medicine, 2005Glutamine synthetase plays a major role in ammonia detoxification, interorgan nitrogen flux, acid-base homeostasis, and cell signaling. We report on two unrelated newborns who had congenital human glutamine synthetase deficiency with severe brain malformations resulting in multiorgan failure and neonatal death.
Johannes, Häberle +11 more
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Glutamine synthetase deficiency
2020Prenatal onset malformations of the brain, seizures, necrolytic erythema of the skin, enteropathy with diarrhea, early neonatal death, and multiorgan failure or chronic encephalopathy and developmental delay, hyperammonemia, low concentration of glutamine in plasma and cerebrospinal fluid, and deficient activity of glutamine synthetase.
William L. Nyhan +3 more
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Equine placenta expresses glutamine synthetase
Veterinary Research Communications, 2008In most mammalian species the developing fetus utilizes large amounts of glutamine derived both from the maternal circulation and synthesized de novo in the placenta. The present study was designed to determine the role of the placenta in glutamine synthesis in the horse.
Hélio C, Manso Filho +4 more
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Regulation of Glutamine Synthetase Activity
EcoSal Plus, 2004Detailed studies of the glutamine synthetase (GS) in Escherichia coli and other bacteria have shown that the activity of this enzyme is regulated by at least five different mechanisms: (i) cumulative feedback inhibition by multiple end products of glutamine metabolism, (ii) interconversion between taut and relaxed ...
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[Glutamine synthetase immobilization].
Prikladnaia biokhimiia i mikrobiologiia, 1978Highly purified glutamine synthetase has been isolated from Chlorella and immobilized on BrCN-sepharose. Its residual activity was 25-35%. Immobilized glutamine synthetase showed far greater thermal stability than glutamine synthetase in solution. During immobilization pH optimum of the enzyme was shifted towards the alkaline area, maximum rate of the ...
A S, Rasulov, Z G, Evstigneeva
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Intrahippocampal kainic acid reduces glutamine synthetase
Neuroscience, 1990Kainic acid was injected into the hippocampus of rats and glutamine synthetase was measured to determine whether astrocytes are involved in the early effects of this neurotoxic agent. Glutamine synthetase was reduced by 38%, 24 h after the stereotaxic application of 4 nmol of kainic acid to this region.
R A, Waniewski, D, McFarland
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Localisation of Glutamine Synthetase in Chloroplasts
Nature New Biology, 1973Glutamine is of considerable importance in plants, as a readily metabolised and translocated intermediate and as a product of ammonia detoxification. Glutamine synthetase carries out the ATP-driven addition of ammonia to glutamate to produce the amide. The source of ATP and information on the metabolic role, for glutamine synthetase may be suggested by
D, O'Neal, K W, Joy
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