Results 281 to 290 of about 91,004 (324)

Mitigation Potential of Greenhouse Gas Emissions Through Nitrogen‐Water Management Optimization in Major Asian Rice Regions

open access: yesEarth's Future, Volume 13, Issue 12, December 2025.
Abstract Rice production represents a major global food source and a significant contributor to greenhouse gas (GHG) emissions. While nitrogen fertilization and water‐saving irrigation are recognized as effective GHG mitigation strategies in rice cultivation, their synergistic effects and underlying mechanisms remain inadequately characterized.
Zizun Wei   +5 more
wiley   +1 more source

Metagenomic Insights Into the Ecology, Taxonomy and Metabolic Capabilities of ‘Candidatus Darwinibacteriales’ Ord. Nov. (Formerly MBA03), a Potential Key Player in Anaerobic Digestion

open access: yesMicrobial Biotechnology, Volume 18, Issue 12, December 2025.
Metagenomic analysis of anaerobic digesters revealed a dominant, uncultured bacterial taxon—MBA03—now proposed as ‘Candidatus Darwinibacteriales’ ord. nov. This newly defined order includes potential syntrophic acetate‐oxidising bacteria (SAOB), suggesting a key role in methane production.
Roser Puchol‐Royo   +9 more
wiley   +1 more source

Unveiling the Potential of Lentilactobacillus hilgardii in Malolactic Fermentation: Comparative Genomics and Fermentation Dynamics

open access: yesMicrobial Biotechnology, Volume 18, Issue 12, December 2025.
This study explores the metabolic potential of Lentilactobacillus hilgardii for malolactic fermentation in winemaking. Genomic and in silico analyses, combined with experimental validation, reveal its resilience at low temperatures and unique enzymatic traits. Comparative insights with Oenococcus oeni highlight L.
Giacomo Mantegazza   +5 more
wiley   +1 more source

Effects of methotrexate on Wnt/β‐catenin signaling and glial activation in temporomandibular joint arthritis in rats

open access: yesEuropean Journal of Oral Sciences, Volume 133, Issue 6, December 2025.
Abstract Rheumatoid arthritis is a chronic autoimmune disease that can affect the temporomandibular joint (TMJ) and cause pain. Methotrexate is widely used to control disease progression, but its effects on pain mechanisms are not fully understood. This study evaluated the antinociceptive effects of methotrexate on pain behavior, Wnt/β‐catenin pathway ...
Ana Carolina de Figueiredo Costa   +6 more
wiley   +1 more source

Pathology reporting of hepatoblastoma resections: recommendations from the international collaboration on cancer reporting

open access: yesHistopathology, Volume 87, Issue 6, Page 802-814, December 2025.
This is the first international dataset for the reporting of hepatoblastoma resection specimens produced by the International Collaboration on Cancer Reporting (ICCR). The aim is to standardize pathology reports, facilitating international data comparisons and improving management of hepatoblastoma on a global level.
Dolores H López‐Terrada   +13 more
wiley   +1 more source

Identification of Glutathione Synthetase as a Therapeutic Target for Cervical Cancer via Combining Bioinformatics and Experimental Validation

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 24, December 2025.
ABSTRACT Cervical cancer remains a leading cause of cancer‐related mortality among women worldwide, posing a severe threat to female health. Previous research indicates that cuproptosis is a copper‐dependent form of regulated cell death, holding potential as a therapeutic avenue. This study aimed to identify and validate Cuproptosis‐Related Genes (CRGs)
Meini Pan   +8 more
wiley   +1 more source

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health

open access: yesJournal of Neurochemistry, Volume 169, Issue 12, December 2025.
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Osmar Vieira Ramires Júnior   +5 more
wiley   +1 more source

GmMEKK2 Disrupts the MKK1/2–MPK4 Cascade to Amplify Immune Signalling and Confer Enhanced Resistance to Soybean Mosaic Virus

open access: yesMolecular Plant Pathology, Volume 26, Issue 12, December 2025.
Overexpressing GmMEKK2 in soybean (Glycine max) blocks the MEKK1‐MKK1‐MPK4 cascade via protein interaction, triggering defence responses. An increase in reactive oxygen species levels and elevated expression of defence genes such as PR1 leads the plant to exhibit an autoimmune state, enhancing resistance to SMV.
Xuanbo Zhong   +5 more
wiley   +1 more source

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