Results 291 to 300 of about 91,004 (324)

2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase

Herdering E, Reif-Trauttmansdorff T, Kumar A, Habenicht T, Hochberg G, Bohn S, Schuller J, Schmitz RA.   +7 more
europepmc   +1 more source

Blue light‐induced stomatal opening is associated with species‐specific changes in primary metabolism but not with starch breakdown in guard cells

New Phytologist, Volume 248, Issue 5, Page 2347-2360, December 2025.
Summary Blue light (BL)‐induced stomatal opening has been associated with starch breakdown within Arabidopsis guard cells (GCs). However, whether this mechanism is conserved in angiosperms and which metabolic pathways are activated downstream of BL perception and/or starch degradation, remains unknown.
Humaira Bahadar, Eva Gomes Morais, Francisco Bruno S. Freire, Valéria F. Lima, Marina Ellen Giacomelli, Leticia dos Anjos, Werner Camargos Antunes, Danilo M. Daloso   +7 more
wiley   +1 more source

Long non-coding RNA PXN-AS1 promotes glutamine synthetase-mediated chronic myeloid leukemia BCR::ABL1-independent resistance to Imatinib via cell cycle signaling pathway. [PDF]

Cancer Cell Int
Li Y, Yuan S, Zhou Y, Zhou J, Zhang X, Zhang P, Xiao W, Zhang Y, Deng J, Lou S.   +9 more
europepmc   +1 more source

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Glutamine synthetase and hepatocellular carcinoma

Clinics and Research in Hepatology and Gastroenterology, 2023
Glutamine synthetase (GS) is an enzyme that converts ammonia and glutamate to glutamine using adenosine triphosphate. GS is expressed in the brain, kidney, and liver tissues under normal physiological conditions. GS is involved in abnormal lipid metabolism of the liver by catalyzing de novo synthesis of glutamine, thereby inducing liver inflammation ...
Jinghua, Jiang, Yiting, Hu, Dazhang, Fang, JianSheng, Luo   +3 more
openaire   +2 more sources

Congenital Glutamine Deficiency with Glutamine Synthetase Mutations

New England Journal of Medicine, 2005
Glutamine synthetase plays a major role in ammonia detoxification, interorgan nitrogen flux, acid-base homeostasis, and cell signaling. We report on two unrelated newborns who had congenital human glutamine synthetase deficiency with severe brain malformations resulting in multiorgan failure and neonatal death.
Johannes, Häberle, Boris, Görg, Frank, Rutsch, Eva, Schmidt, Annick, Toutain, Jean-François, Benoist, Antoinette, Gelot, Annie-Laure, Suc, Wolfgang, Höhne, Freimut, Schliess, Dieter, Häussinger, Hans G, Koch   +11 more
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Localisation of Glutamine Synthetase in Chloroplasts

Nature New Biology, 1973
Glutamine is of considerable importance in plants, as a readily metabolised and translocated intermediate and as a product of ammonia detoxification. Glutamine synthetase carries out the ATP-driven addition of ammonia to glutamate to produce the amide. The source of ATP and information on the metabolic role, for glutamine synthetase may be suggested by
D, O'Neal, K W, Joy
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Induction of glutamine synthetase by cortisol

Biochimica et Biophysica Acta (BBA) - General Subjects, 1968
Abstract A 2-fold increase in the activity of hepatic glutamine synthetase ( L -glutamate: ammonia ligase (ADP), EC 6.3.1.2) was observed following the administration of cortisol to adrenalectomized rats and this response was prevented by actinomycin D.
P N, Raina, F, Rosen
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Glutamine synthetase deadenylylating enzyme

Biochemical and Biophysical Research Communications, 1968
The glutamine synthetase of Escherichiacoli exists in various forms differing from each other by their content of covalently bound adenylyl groups (Shapiro etal., 1967;Wulff etal., 1967). The biosynthetic activity of unadenylylated glutamine synthetase is very much greater with Mg2+ as the activating cation than with Mn2+, and its γ-glutamyl ...
B M, Shapiro, E R, Stadtman
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Distribution of glutamine synthetase and an inverse relationship between glutamine synthetase expression and intramuscular glutamine concentration in the horse

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2008
Glutamine plays important roles in the interorgan transport of nitrogen, carbon and energy but little is known about glutamine metabolism in the horse. In this study we determined the tissue distribution of glutamine synthetase expression in three Standardbred mares.
Helio C, Manso Filho, Helena Emilia C, Costa, Yanxin, Wang, Kenneth H, McKeever, Malcolm, Watford   +4 more
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The optical specificity of glutamine synthetase

Archives of Biochemistry and Biophysics, 1960
The optical specificity of the glutamine synthetase isolated from dried peas has been studied. The degree of optical specificity shown by the enzyme is a function of the pH, the activating meta-lion concentration, the metal-ion species and the concentration of ammonia or hydroxylamine.
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