Results 21 to 30 of about 88 (85)

Dystonia and Infantile Glutaric Acidemia

Pediatric Neurology Briefs, 1989
Glutaric acidemia, an autosomal recessively inherited disease caused by deficiency of glutaryl-CoA dehydrogenase, was manifested by acute dystonia in 3 infants reported from the Children's Hospital of Pittsburgh, Pennsylvania.
openaire   +4 more sources

Enhancing Form Stability: Shrink‐Resistant Hydrogels Made of Interpenetrating Networks of Recombinant Spider Silk and Collagen‐I

Advanced Healthcare Materials, Volume 14, Issue 12, May 6, 2025.
A shrinkage‐resistant hydrogel is developed to confer post‐fabrication shape fidelity. The hydrogel, based on recombinant spider silk protein eADF4(C16)‐RGD and collagen‐I, exhibits tunable mechanical properties and shrink‐resistance in the presence of fibroblasts as well as muscle cells.
Xuen J. Ng, Tilman U. Esser, Vanessa T. Trossmann, Christoph Rudisch, Maren Fiedler, Kaveh Roshanbinfar, Zan Lamberger, Philipp Stahlhut, Gregor Lang, Thomas Scheibel, Felix B. Engel   +10 more
wiley   +1 more source

Topologically associating domains and the evolution of three‐dimensional genome architecture in rice

The Plant Journal, Volume 122, Issue 4, May 2025.
SUMMARY We examined the nature and evolution of three‐dimensional (3D) genome conformation, including topologically associating domains (TADs), in five genomes within the genus Oryza. These included three varieties from subspecies within domesticated Asian rice O. sativa as well as their closely related wild relatives O. rufipogon and O.
Amina Kurbidaeva, Sonal Gupta, Maricris Zaidem, Raúl Castanera, Yutaka Sato, Zoé Joly‐Lopez, Josep M. Casacuberta, Michael D. Purugganan   +7 more
wiley   +1 more source

Metabolic Engineering of Corynebacterium glutamicum for High‐Level Production of 1,5‐Pentanediol, a C5 Diol Platform Chemical

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study develops an efficient biosynthesis system for 1,5‐pentanediol (1,5‐PDO) in Corynebacterium glutamicum, an important compound for industrial applications. By engineering the l‐lysine degradation pathway, 5‐hydroxyvaleric acid (5‐HV) is synthesized from glucose as a key intermediate.
Yu Jung Sohn, Se‐Yeun Hwang, Haeyoung Lee, Subeen Jeon, Ji Young Park, Jaehyung Kim, Donghyuk Kim, Ki Jun Jeong, Sang Yup Lee, Jeong Chan Joo, Jin‐Byung Park, Si Jae Park   +11 more
wiley   +1 more source

Bioactive hemostatic materials: a new strategy for promoting wound healing and tissue regeneration

MedComm, Volume 6, Issue 4, April 2025.
This paper reviews the current status and latest advancements in the field of hemostatic materials, focusing on the mechanism of hemostasis and wound healing, the chemical design principles and physiological mechanisms of hemostatic materials, and the comparison of different active ingredients and dosage forms.
Zhengyuan Liu, Junnan Xu, Xing Wang
wiley   +1 more source

Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood‐Testis Barrier in Mice

Advanced Science, Volume 12, Issue 10, March 13, 2025.
Exposure to PFHxS disrupts the immune‐isolated microenvironment and mitochondrial function homeostasis during spermatogenesis. Subsequently, it up‐regulates the metabolite β‐hydroxybutyrate which is involved in the post‐translational modification of proteins, and resulting in a decrease in histone acetylation level.
Yan Zhang, Mingxue Shu, Shilin Shan, Huiying Liu, Yucheng Zhang, Chenyang Song, Qiaoqiao Xu, Yun Fan, Chuncheng Lu   +8 more
wiley   +1 more source

Orthopaedic manifestations of glutaric acidemia Type 1

Journal of Children's Orthopaedics, 2020
Purpose Glutaric acidemia type 1 (GA1), a rare hereditary metabolic disease caused by biallelic mutations of GCDH, can result in acute or insidious striatal degeneration within the first few years of life. We reviewed the orthopaedic sequelae and management of 114 neurologically injured patients with a confirmed molecular diagnosis of GA1.
İmerci, Ahmet, Strauss, Kevin A, Oleas-Santillan, Geovanny F, Miller, Freeman   +3 more
openaire   +4 more sources

Quorum Sensing Coordinates Carbon and Nitrogen Metabolism to Optimize Public Goods Production in Pseudomonas fluorescens 2P24

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Pseudomonas fluorescens 2P24 utilizes a LasI/LasR‐type quorum sensing (QS) system, MupI/MupR, to regulate carbon and nitrogen metabolism for optimal production of secondary metabolites as public goods, including 2,4‐diacetylphloroglucinol, mupirocin, and siderophores.
Jie Li, Mengxue Nie, Hongguang Ma, Xuanying Tao, Yanxia Sun, Xinyue Tu, Pingping Zhang, Li‐Qun Zhang, Rong Jia, Yong‐Xing He, Nannan Zhang, Honghua Ge   +11 more
wiley   +1 more source

Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation‐Mediated FGFR4 Activation

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study indicates that Lgals3 plays a potential novel therapeutic target for the prevention of Calcium oxalate (CaOx) stone formation and subsequent renal fibrosis. Elevated Lgals3 interacted with PKM2 and promote the expression of FGFR4 via histone H3K18 lactylation, thereby facilitating CaOx crystal deposition and the development of renal fibrosis.
Zehua Ye, Yushi Sun, Songyuan Yang, Lei Li, Bojun Li, Yuqi Xia, Tianhui Yuan, Weimin Yu, Lijia Chen, Xiangjun Zhou, Fan Cheng   +10 more
wiley   +1 more source

Glutarate metabolism in Pseudomonas putida is regulated by two distinct glutarate sensing transcription factors [PDF]

, 2019
ABSTRACTTranscription factor based biosensors can be leveraged to screen thousands of genetics designs for optimal production in engineered microbes. In this study we characterize two glutarate sensing transcription factors (CsiR and GcdR) from Pseudomonas putida.
Pablo Cruz-Morales, Pablo Cruz-Morales, Pablo Cruz-Morales, Mitchell G. Thompson, Mitchell G. Thompson, Mitchell G. Thompson, Jacquelyn M. Blake-Hedges, Jacquelyn M. Blake-Hedges, Jacquelyn M. Blake-Hedges, Rohith N. Krishna, Rohith N. Krishna, Rohith N. Krishna, Patrick M. Shih, Patrick M. Shih, Zak Costello, Zak Costello, Hector Garcia-Martin, Niklas F. C. Hummel, Niklas F. C. Hummel, Jay D. Keasling, Matthew R. Incha, Matthew R. Incha, Matthew R. Incha, Allison N. Pearson, Allison N. Pearson, Will Skyrud   +25 more
openaire   +3 more sources