Results 31 to 40 of about 917 (174)

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Riboflavin (RF, vitamin B2) is an essential vitamin of which the co‐factors are critical to numerous cellular processes. RF is used as a treatment for inherited metabolic diseases (IMDs), although its effectiveness in many disorders has not been established.
Bregje Jaeger, Nina N. Stolwijk, Femke Aaldering, Charlotte A. Ruys, Marije Smits, Nicole I. Wolf, Carla E. M. Hollak, Annet M. Bosch   +7 more
wiley   +1 more source

Advances in Wine Yeast Autolysis: Biochemical and Molecular Mechanisms, and the Release of Organic Compounds in White and Sparkling Wines—An Updated Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Wine yeasts play a central role in alcoholic fermentation and significantly contribute to the sensory attributes of wines through cellular autolysis during lees aging (sur lie), especially in white wines. This process releases organic compounds that alter the wine's chemical and sensory profile.
José Ricardo Machado dos Santos, Aniela Pinto Kempka   +1 more
wiley   +1 more source

Anxiety Disorder Types From a Metabolomics Perspective: A Mendelian Randomization Analysis Based on 1400 Plasma Metabolites

Brain and Behavior, Volume 16, Issue 4, April 2026.
This study investigates the causal relationship between plasma metabolites and three common types of anxiety disorders using Mendelian randomization analysis. Our findings propose a novel direction for utilizing metabolites as biomarkers in the diagnosis and treatment of anxiety disorders.
Zhen Xiao, Zedi Wu, Zixin Chen, Ziyue Xu, Qi Zhou, Silan Liu, Muqing Wang, Shujun Hou, Wanling Liu, Zhengyi Li, Kunping Xun, Ning Zhang, Chun Wang   +12 more
wiley   +1 more source

Glutarate regulates T cell metabolism and anti-tumour immunity [PDF]

, 2023
T cell function and fate can be influenced by several metabolites: in some cases, acting through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through post-translational modification of lysines in important targets.
Antrobus, Robin, Barbieri, Laura, Bargiela, David, Cunha, Pedro P., Foskolou, Iosifina P., Grice, Guinevere L., Hughes, Rob, Johnson, Randall S., Koivunen, Peppi, Minogue, Eleanor, Nathan, James A., Quaranta, Alessandro, Sah-Teli, Shiv K., Velica, Pedro, Wadsworth, Brennan J., Wheelock, Craig E., Zurita, Javier   +16 more
core   +1 more source

Amphiphilic Polymer Model Networks Synthesized by Different Hetero‐Complementary Coupling Reactions of Tetra‐PEG and Tetra‐PCL Stars

Macromolecular Chemistry and Physics, Volume 227, Issue 7, 14 April 2026.
Amphiphilic co‐networks (ACN) synthesized by different hetero‐complementary reactions of hydrophilic tetra‐PEG and hydrophobic tetra‐PCL stars are compared. For the ACNs, equilibrium volume swelling degrees (Qv) are determined. Information about the ACNs micro structure (connectivity distribution) is obtained from proton low‐resolution multiple‐quantum
Stephanie Ihmann, Bidit Lamsal, Martin Geisler, Kay Saalwächter, Frank Böhme   +4 more
wiley   +1 more source

Porous Hexacyanometallate(III) Complexes as Catalysts in the Ring-Opening Copolymerization of CO2 and Propylene Oxide [PDF]

, 2021
In this work, six porous hexacyanometallate complexes (Ni3[Co(CN)6]2, Co3[Co(CN)6]2, Fe3[Co(CN)6]2, Ni3[Fe(CN)6]2, Co3[Fe(CN)6]2, Fe4[Fe(CN)6]2) were synthesized by a complexing agent assisted coprecipitation method and thoroughly characterized via X-ray
González Marcos, María Pilar, González Velasco, Juan Ramón, Penche, Guillermo   +2 more
core   +1 more source

Lueyang Black‐Boned Chicken and Black Bean Soup Promoting the Acute Healing of Skin Wounds, Accompanying Special Flavor Substances

Food Chemistry International, Volume 2, Issue 1, Page 46-57, March 2026.
ABSTRACT Animal protein and plant protein make the protein supplement more comprehensive and further optimize the nutritional structure of the national diet. In this study, a “dual protein” Lueyang black‐boned chicken and black bean soup (FS) was prepared.
Mengya Zhao, Zining Luo, Pengyan Tong, Yining Jia, Xin Yang, Jing Liu, Fangyu Long   +6 more
wiley   +1 more source

Nanostructures in Water-in-CO₂ Microemulsions Stabilized by Double-chain Fluorocarbon Solubilizers [PDF]

, 2013
High-pressure small-angle neutron scattering (HP-SANS) studies were conducted to investigate nanostructures and interfacial properties of water-in-supercritical CO2 (W/CO2) microemulsions with double-fluorocarbon-tail anionic surfactants, having ...
Cummings, Stephen, Eastoe, Julian, Heenan, Richard K, Iwama, Shuho, James, Craig, Mohamed, Azmi, Ono, Shinji, Rogers, Sarah E, Sagisaka, Masanobu, Yan, Ci, Yoshizawa, Atsushi   +10 more
core   +1 more source

Engineering Cyanobacteria for High‐Yield Photosynthetic Isoprene Production With Long‐Term Phenotypic Stability

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1014-1030, March 2026.
Center: Cyanobacterial isoprene production from CO2 and sunlight. Top: CRISPR‐editing for generation of markerless production strains. Top right: Long‐term production assay for strain stability assessment. Bottom right: Engineering of MEP pathway and surrounding metabolism for bottleneck idenfication. Bottom left: Relief of bottleneck by overproduction
Kim N. Janssen, Paul Bolay, Adrian Tüllinghoff, Jörg Toepel, Daniel Spindler, Bruno Bühler, Pia Lindberg   +6 more
wiley   +1 more source