Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer [PDF]
, 2022 Resistance to cancer therapeutics represents a leading cause of mortality and is particularly important in cancers, such as triple negative breast cancer, for which no targeted therapy is available, as these are only treated with traditional ...
Castellanos-Uribe, M +3 more
core +2 more sources
Polymeric aqua(glutarato)(hydrogen glutarato)lanthanum(III) monohydrate [PDF]
, 2006 The structure of the title compound, [La(C5H6O4)(C5H7O4)(H2O)] . H2O, consists of dense layers formed by chains of one-edge-sharing LaO9 (H2O) polyhedra, linked together by the glutarate ligand. The three-dimensional polymeric structure, built up through
Balegroune, F. +4 more
core +1 more source
New Catalytic Systems for Fixation of Carbon Dioxide into Valuable Poly(Alkylene Carbonates) [PDF]
, 2016 Fixation of carbon dioxide into valuable products is a promising method to mitigate the issues of global warming and decrease the consumption of fossil-fuel carbon sources.
Bahramian, Bahareh, Dehghani, Fariba
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An Efficient Process for Pretreatment of Lignocelluloses in Functional Ionic Liquids [PDF]
, 2015 Background and Aims. The complex structure of the lignocelluloses is the main obstacle in the conversion of lignocellulosic biomass into valuable products. Ionic liquids provide the opportunities for their efficient pretreatment for biomass.
Bi-Xian Zhang +3 more
core +2 more sources
Desymmetrization of meso-methylenecyclopropanes by a palladium-catalyzed asymmetric ring-opening bis(alkoxycarbonylation) reaction [PDF]
, 2014 Desymmetrization of various meso-methylenecyclopropanes was accomplished by a palladium-catalyzed asymmetric ring-opening bis(alkoxycarbonylation) reaction employing a chiral bioxazoline ligand. The reaction proceeded smoothly in the presence of copper(I)
Aratani Takahiro +5 more
core +2 more sources
Multi-Omics to Illuminate Signaling Molecules of the Gut Microbiota-Brain Axis [PDF]
, 2021 The human gastrointestinal (GI) tract harbors hundreds of trillions of microorganisms, collectively referred to as the gut microbiota. Complex, dynamic, and metabolically active by nature, these commensal microbes carry critical functional roles in ...
Lai, Yunjia
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Comprehensive metabolomic study of the response of HK-2 cells to hyperglycemic hypoxic diabetic-like milieu [PDF]
, 2021 Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Although hyperglycaemia has been determined as the most important risk factor, hypoxia also plays a relevant role in the development of this disease.
Castro Puyana, María +5 more
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Rapid Communications in Mass Spectrometry, EarlyView.ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler +7 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1192-1203, June 2026.ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt +9 more
wiley +1 more source
SYNTHESIS AND EVALUATION OF SOME ARYLALKENYL AND ARYLEPOXYALKYL HYDROGEN SUCCINATES AND HYDROGEN GLUTARATES AS INHIBITORS OF RAT LIVER β-HYDROXY-β-METHYLGLUTARYL COENZYME A REDUCTASE [PDF]
, 1974 Atherosclerotic disease is an almost universal phenomenon and increases in severity and frequency with increasing age. Atherosclerosis may contribute to several disorders including bursting of an artery, blockage of an artery, or induction of arterial ...
Marecki, Paul Emil
core +1 more source