Results 31 to 40 of about 893 (156)

Development of tCAP(N3): Affinity Peptide‐Aided, pH‐Triggered Strategy for Site‐Specific Native IgG Modification

Chemistry – A European Journal, Volume 32, Issue 6, 9 February 2026.
The tCAP(N3) reagent, featuring a stable and self‐activating precursor, enables site‐specific conjugation of native IgGs. This Fc‐affinity peptide approach selectively transfers an Ac‐Lys(N3)‐Gly‐Gly payload to Lys248, producing divalently azidated antibody while preserving its biological function.
Hiroko Kawakami, Abdur Rafique, Shugo Tsuda, Asaki Nagashima, Yukie Nohara, Naoki Dozono, Ken Sakamoto, Shun Masuda, Masato Kiyoshi, Hiroko Shibata, Akiko Ishii‐Watabe, Taku Yoshiya, Yuji Ito   +12 more
wiley   +1 more source

Antimalarial Polyethylene Glycol–Lumefantrine Conjugates: Synthesis and Effect of Linker Chemistry on Drug Release

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Research into advanced therapeutics for malaria are rare. We investigate how linker chemistry governs the release kinetics of the antimalarial lumefantrine from polyethylene glycol conjugates. A clear correlation between diacid linker length and drug release rate is established, enabling rational design of conjugates with controlled release.
Thenesia R. Govender, William M. R. Matshe, Nokuthula Dube, Zamani E. D. Cele, Aurelia A. Williams, Lynne A. Pilcher, Mohammed O. Balogun   +6 more
wiley   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, Volume 13, Issue 8, 9 February 2026.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Structural Studies by X-Ray and Neutron Diffraction [PDF]

, 1971
This thesis is concerned with the application of neutron and X-ray diffraction techniques to the study of hydrogen bonding in the acid salts of some simple carboxylic acids and, in particular, those of glutaric acid. It is divided into three parts.
MacDonald, Alistair L
core  

Nanostructures in Water-in-CO₂ Microemulsions Stabilized by Double-chain Fluorocarbon Solubilizers [PDF]

, 2013
High-pressure small-angle neutron scattering (HP-SANS) studies were conducted to investigate nanostructures and interfacial properties of water-in-supercritical CO2 (W/CO2) microemulsions with double-fluorocarbon-tail anionic surfactants, having ...
Cummings, Stephen, Eastoe, Julian, Heenan, Richard K, Iwama, Shuho, James, Craig, Mohamed, Azmi, Ono, Shinji, Rogers, Sarah E, Sagisaka, Masanobu, Yan, Ci, Yoshizawa, Atsushi   +10 more
core   +1 more source

Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application

MedComm, Volume 7, Issue 2, February 2026.
Hydrogels offer an innovative platform for cancer immunotherapy. Through tailorable crosslinking strategies, they form customizable drug delivery platforms that address diverse therapeutic requirements by loading specific immunotherapeutic agents. These systems demonstrate significant clinical potential for precise tumor immunotherapy.
Xiaohua Chen, Shan Wu, Yueyang Zhang, Lilu Feng, Yang Chen, Xuzhao Yang, Ke Men, Jiuqun Zhu, Ming Li   +8 more
wiley   +1 more source

Role of Altered Metabolites and Metabolic Pathways in Major Tuber Crops Under Drought Stress

Plant-Environment Interactions, Volume 7, Issue 1, February 2026.
ABSTRACT Drought stress poses a significant challenge to growth and productivity of major tuber crops, particularly cassava (Manihot esculenta Crantz), potato (Solanum tuberosum L.) and sweet potato (Ipomoea batatas (L.) Lam.). These crops are among the most widely cultivated tubers globally and play a critical role in food and nutritional security ...
Maltase Mutanda, Fikile N. Makhubu, Sandiswa Figlan   +2 more
wiley   +1 more source

Hydrolysis of peptide bonds : participation of a carboxyl group in amide hydrolysis [PDF]

, 1967
In order to assess the effect of substituents on the participation of a neighbouring carboxyl group in the hydrolysis of amides, seventeen substituted succinamic acids have been prepared.
Jones, F. W.
core   +1 more source

Glucuronoyl Esterase of Pathogenic Phanerochaete carnosa Induces Immune Responses in Aspen Independently of Its Enzymatic Activity

Plant Biotechnology Journal, Volume 24, Issue 2, Page 602-619, February 2026.
ABSTRACT Microbial enzymes expressed in plants add new functionalities but occasionally trigger undesirable immune responses. Phanerochaete carnosa glucuronoyl esterase (PcGCE) hydrolyses the bond between lignin and 4‐O‐methyl‐α‐D‐glucuronic acid substituent of glucuronoxylan.
Evgeniy N. Donev, Marta Derba‐Maceluch, Xiao‐Kun Liu, Henri Colyn Bwanika, Izabela Dobrowolska, Mohit Thapa, Joanna Leśniewska, Jan Šimura, Alex Yi‐Lin Tsai, Konrad S. Krajewski, Dan Boström, Leszek A. Kleczkowski, Maria E. Eriksson, Karin Ljung, Emma R. Master, Ewa J. Mellerowicz   +15 more
wiley   +1 more source