Results 91 to 100 of about 5,871 (233)

Primary hyperoxaluria Type 1: organic aciduria diagnosed in plasma [PDF]

, 2013
Background: Primary hyperoxaluria Type 1 (PH1) is a rare autosomal recessive inborn error of glyoxylate metabolism, caused by a deficiency of the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase.
Dias, Aureliano, Rodrigues, Marilia, Valongo, Carla, Vilarinho, Laura   +3 more
core  

Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease.

PLoS ONE, 2011
Previously, we demonstrated that allopregnanolone (APα) promoted proliferation of rodent and human neural progenitor cells in vitro. Further, we demonstrated that APα promoted neurogenesis in the hippocampal subgranular zone (SGZ) and reversed learning ...
Shuhua Chen, Jun Ming Wang, Ronald W Irwin, Jia Yao, Lifei Liu, Roberta Diaz Brinton   +5 more
doaj   +1 more source

Undercover: Gene control by metabolites and metabolic enzymes [PDF]

, 2016
To make the appropriate developmental decisions or maintain homeostasis, cells and organisms must coordinate the expression of their genome and metabolic state. However, the molecular mechanisms that relay environmental cues such as nutrient availability
Knaap, J.A. (Jan) van der, Verrijzer, C.P. (Peter)   +1 more
core   +2 more sources

3-Hydroxyglutaric acid fails to affect the viability of primary neuronal rat cells

Neurobiology of Disease, 2004
Glutaric aciduria type I (GA I) is an autosomal recessive inherited metabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase (GCD) resulting in the accumulation of 3-hydroxyglutaric acid (3OHG), glutaric acid and glutaconic acid in body ...
F Freudenberg, Z Lukacs, K Ullrich
doaj   +1 more source

Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profile in patients with ulcerative colitis [PDF]

, 2012
Background Accurate diagnostic and monitoring tools for ulcerative colitis (UC) are missing. Our aim was to describe the proteomic profile of UC and search for markers associated with disease exacerbation.
A Shkoda, ACJ Polley, AI Thompson, BA Jacobsen, CA Anderson, D Ludwig, DC Baumgart, DK Podolsky, DW Day, EM Comelli, F Wu, Flemming Jessen, G Roda, Hanne Søndergaard Møller, HM Moore, JD Lewis, JD Storey, Jens Christian Møller, JL Mendoza, K Araki, K Geboes, K Kok, KN Jensen, L Kruidenier, L Kruidenier, L Kruidenier, L LihBrody, Lotte Bach Larsen, LV Lopes, M Mann, M Vatn, MA Meuwis, MA Meuwis, N Vermeulen, Nina Aagaard Poulsen, ON Jensen, P Alex, P Nanni, P Nanni, P Von Stein, R Lametsch, RM Aaronson, S Din, S Kanmura, S Turroni, Stig Purup, SY Hsieh, T Werner, U Dagli, V Andersen, V Andersen, V Andersen, Vibeke Andersen, VR Winrow, WEW Roediger, XH Li   +55 more
core   +2 more sources

Isolation of isoprene degrading bacteria from soils, development of isoA gene probes and identification of the active isoprene degrading soil community using DNA-stable isotope probing [PDF]

, 2016
Emissions of biogenic volatile organic compounds (bVOCs), are an important element in the global carbon cycle, accounting for a significant proportion of fixed carbon.
Acuña Alvarez, Altschul, Atkinson, Bertoni, Broadgate, Bäck, Capone, Cardy, Cleveland, Cleveland, Cole, Crombie, Dowd, Dumont, Edgar, Ensign, Ewers, Exton, Fiore, Gelmont, Ginkel, Ginkel, Gray, Greenberg, Guenther, Hylckama Vlieg, Hylckama Vlieg, Hylckama Vlieg, Julsing, Kirschke, Kottegoda, Kuzma, Lane, Leahy, Logan, Loivamäki, Loreto, Marmur, McLeod, Muyzer, Neufeld, Pacifico, Pegoraro, Radajewski, Schaefer, Sharkey, Sharkey, Srivastva, Tamura, Tuovinen, Vickers, Wiedinmyer, Wiedinmyer, Zhou   +53 more
core   +1 more source

Cloning, Structure, and Chromosome Localization of the Mouse Glutaryl-CoA Dehydrogenase Gene

Genomics, 1995
Glutaryl-CoA dehydrogenase (GCDH) is a nuclear-encoded, mitochondrial matrix enzyme. In humans, deficiency of GCDH leads to glutaric acidemia type I, an inherited disorder of amino acid metabolism characterized by a progressive neurodegenerative disease. In this report we describe the cloning and structure of the mouse GCDH (Gcdh) gene and cDNA and its
D M, Koeller, K A, DiGiulio, S V, Angeloni, L L, Dowler, F E, Frerman, R A, White, S I, Goodman   +6 more
openaire   +2 more sources

Glutaric Aciduria Type I Diagnosis Case with Normal Glutaryl Carnitine and Urine Organic Acid Analysis

Journal of Pediatric Research, 2018
Glutaric aciduria Type I (GA-I) is a rare inherited metabolic disease, deficiency of glutaryl-CoA dehydrogenase results in accumulation of the putatively neurotoxic metabolites glutaric and 3-hydroxyglutaric acid (GA, 3-OH-GA) in body tissues ...
Ebru Canda, Havva Yazıcı, Esra Er, Cenk Eraslan, Yasemin Atik Altınok, Hepsen Mine Serin, Sara Habif, Gül Serdaroğlu, Sema Kalkan Uçar, Hüseyin Onay, Ferda Özkınay, Mahmut Çoker   +11 more
doaj   +1 more source

Increased glutamate receptor and transporter expression in the cerebral cortex and striatum of gcdh-/- mice: possible implications for the neuropathology of glutaric acidemia type I.

PLoS ONE, 2014
We determined mRNA expression of the ionotropic glutamate receptors NMDA (NR1, NR2A and NR2B subunits), AMPA (GluR2 subunit) and kainate (GluR6 subunit), as well as of the glutamate transporters GLAST and GLT1 in cerebral cortex and striatum of wild type
Valeska Lizzi Lagranha, Ursula Matte, Talita Giacomet de Carvalho, Bianca Seminotti, Carolina Coffi Pereira, David M Koeller, Michael Woontner, Stephen I Goodman, Diogo Onofre Gomes de Souza, Moacir Wajner   +9 more
doaj   +1 more source

Cancer Metabolism: A Modeling Perspective [PDF]

, 2015
Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy.
Ghaffari, Pouyan, Mardinoglu, Adil, Nielsen, Jens   +2 more
core   +1 more source