Results 91 to 100 of about 5,746 (195)

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Glutaric aciduria type 1: a review of phenotypic and genetic characteristics

Journal of Biochemical and Clinical Genetics, 2019
Glutaric aciduria type I (GA1) is an inherited metabolic disorder in which excessive levels of the amino acids lysine, hydroxylysine, and tryptophan accumulate in the body as a result of defective glutaryl-CoA dehydrogenase (GCDH) enzyme activity ...
Ali M AlAsmari, Mohammed M Saleh, Abdul Ali Peer-Zada   +2 more
doaj   +1 more source

Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profile in patients with ulcerative colitis [PDF]

, 2012
Background Accurate diagnostic and monitoring tools for ulcerative colitis (UC) are missing. Our aim was to describe the proteomic profile of UC and search for markers associated with disease exacerbation.
A Shkoda, ACJ Polley, AI Thompson, BA Jacobsen, CA Anderson, D Ludwig, DC Baumgart, DK Podolsky, DW Day, EM Comelli, F Wu, Flemming Jessen, G Roda, Hanne Søndergaard Møller, HM Moore, JD Lewis, JD Storey, Jens Christian Møller, JL Mendoza, K Araki, K Geboes, K Kok, KN Jensen, L Kruidenier, L Kruidenier, L Kruidenier, L LihBrody, Lotte Bach Larsen, LV Lopes, M Mann, M Vatn, MA Meuwis, MA Meuwis, N Vermeulen, Nina Aagaard Poulsen, ON Jensen, P Alex, P Nanni, P Nanni, P Von Stein, R Lametsch, RM Aaronson, S Din, S Kanmura, S Turroni, Stig Purup, SY Hsieh, T Werner, U Dagli, V Andersen, V Andersen, V Andersen, Vibeke Andersen, VR Winrow, WEW Roediger, XH Li   +55 more
core   +2 more sources

Multi‐Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review shows evidence from preclinical and clinical studies, supporting the therapeutic potential of polyphenols for diabetic kidney disease (DKD). This is due to their diverse bioactive properties and ability to intervene in intricate mechanisms of the disease.
Esienanwan E. Efiong, Emmanuel Effa, Esther Peters, Ochuko L. Erukainure, Peter U. Amadi, Joshua Onyeka Ikebuiro, Sapna Sharma, Christoph Schmaderer, Kathrin Maedler, Emmy Tuenter, Harald Grallert   +10 more
wiley   +1 more source

Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease.

PLoS ONE, 2011
Previously, we demonstrated that allopregnanolone (APα) promoted proliferation of rodent and human neural progenitor cells in vitro. Further, we demonstrated that APα promoted neurogenesis in the hippocampal subgranular zone (SGZ) and reversed learning ...
Shuhua Chen, Jun Ming Wang, Ronald W Irwin, Jia Yao, Lifei Liu, Roberta Diaz Brinton   +5 more
doaj   +1 more source

Metabolic signatures and a diagnostic model for citrin deficiency based on urinary organic acids

Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.
Urinary organic acid profiles in NICCD show enrichment in energy and amino acid pathways. The random forest model differentiates NICCD from non‐specific metabolic abnormalities, both with elevated 4‐hydroxyphenyllactic acid and 4‐hydroxyphenylpyruvic acid, which may cause misdiagnosis. Model explanation and web application help physicians make clinical
Peiyao Wang, Peichun Chen, Xinjie Yang, Ziyan Cen, Yu Zhang, Qimin He, Benqing Wu, Xinwen Huang   +7 more
wiley   +1 more source

Seasonal Plasticity in Tryptophan Metabolism Provides New Insights Into Physiological Adaptation in Snake Hibernation

Ecology and Evolution, Volume 15, Issue 9, September 2025.
The microbial pathways of tryptophan metabolism predominate in active snakes, while the 5‐hydroxytryptamine pathway and kynurenine pathway govern tryptophan catabolism in hibernating snakes. ABSTRACT Hibernation is a common behavioral strategy for snakes to cope with extreme environments.
Yuting Wei, Zexiu Zhang, Xiaohong Lin, Gangning Wei, Pengyue Zhang, Huirong Mao, Biao Chen, Jianhao Ji, Yunlin Zheng, Zhiyi Luo, Xiaolong Hu   +10 more
wiley   +1 more source

3-Hydroxyglutaric acid fails to affect the viability of primary neuronal rat cells

Neurobiology of Disease, 2004
Glutaric aciduria type I (GA I) is an autosomal recessive inherited metabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase (GCD) resulting in the accumulation of 3-hydroxyglutaric acid (3OHG), glutaric acid and glutaconic acid in body ...
F Freudenberg, Z Lukacs, K Ullrich
doaj   +1 more source

Cancer Metabolism: A Modeling Perspective [PDF]

, 2015
Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy.
Ghaffari, Pouyan, Mardinoglu, Adil, Nielsen, Jens   +2 more
core   +1 more source

Cloning, Structure, and Chromosome Localization of the Mouse Glutaryl-CoA Dehydrogenase Gene

Genomics, 1995
Glutaryl-CoA dehydrogenase (GCDH) is a nuclear-encoded, mitochondrial matrix enzyme. In humans, deficiency of GCDH leads to glutaric acidemia type I, an inherited disorder of amino acid metabolism characterized by a progressive neurodegenerative disease. In this report we describe the cloning and structure of the mouse GCDH (Gcdh) gene and cDNA and its
D M, Koeller, K A, DiGiulio, S V, Angeloni, L L, Dowler, F E, Frerman, R A, White, S I, Goodman   +6 more
openaire   +2 more sources