Results 101 to 110 of about 17,667 (261)

Phenotypic and Genotypic Characteristics of Adult‐Onset Glutaric Aciduria Type 1: Report of Two Cases and a Literature Review

Brain and Behavior, Volume 15, Issue 2, February 2025.
This study reported two new cases and characterized the phenotype and genotype of adult‐onset glutaric aciduria Type 1 by literature review, emphasizing subependymal lesions and the coexistence of hyperhomocysteinemia. No clear genotype–phenotype correlation was found in adult‐onset glutaric aciduria Type 1. ABSTRACT Introduction Glutaric aciduria Type
Luhua Wei, Jieyu Li, Zhiying Xie, Ying Zhu, Jing Chen, Yawen Zhao, Yun Yuan, Yining Huang, Yanling Yang, Zhaoxia Wang, Jing Chen   +10 more
wiley   +1 more source

Cloning, Structure, and Chromosome Localization of the Mouse Glutaryl-CoA Dehydrogenase Gene

Genomics, 1995
Glutaryl-CoA dehydrogenase (GCDH) is a nuclear-encoded, mitochondrial matrix enzyme. In humans, deficiency of GCDH leads to glutaric acidemia type I, an inherited disorder of amino acid metabolism characterized by a progressive neurodegenerative disease. In this report we describe the cloning and structure of the mouse GCDH (Gcdh) gene and cDNA and its
Lisa L. Dowler, Kathleen Axtell DiGiulio, David M. Koeller, Robert A. White, Frank E. Frerman, Stephen V. Angeloni, Stephen I. Goodman   +6 more
openaire   +3 more sources

Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity

Cell Reports, 2018
Summary: Lysine glutarylation (Kglu) of mitochondrial proteins is associated with glutaryl-CoA dehydrogenase (GCDH) deficiency, which impairs lysine/tryptophan degradation and causes destruction of striatal neurons during catabolic crisis with subsequent
Jessica Schmiesing, Stephan Storch, Ann-Cathrin Dörfler, Michaela Schweizer, Georgia Makrypidi-Fraune, Melanie Thelen, Marc Sylvester, Volkmar Gieselmann, Catherine Meyer-Schwesinger, Friedrich Koch-Nolte, Henning Tidow, Chris Mühlhausen, Abdul Waheed, William S. Sly, Thomas Braulke   +14 more
doaj  

Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease.

PLoS ONE, 2011
Previously, we demonstrated that allopregnanolone (APα) promoted proliferation of rodent and human neural progenitor cells in vitro. Further, we demonstrated that APα promoted neurogenesis in the hippocampal subgranular zone (SGZ) and reversed learning ...
Shuhua Chen, Jun Ming Wang, Ronald W Irwin, Jia Yao, Lifei Liu, Roberta Diaz Brinton   +5 more
doaj   +1 more source

Navigating Metabolic Challenges in Ovarian Cancer: Insights and Innovations in Drug Repurposing

Cancer Medicine, Volume 14, Issue 4, February 2025.
ABSTRACT Background Ovarian cancer (OC) is the most lethal gynecological malignancy and a major global health concern, often diagnosed at advanced stages with poor survival rates. Despite advancements in treatment, resistance to standard chemotherapy remains a critical challenge with limited treatment options available.
Sara Mikhael, Georges Daoud
wiley   +1 more source

Free Energy of Activation for the Comorosan Effect [PDF]

arXiv, 2007
Initial reaction rate data for lactic dehydrogenase / pyruvate, lactic dehydrogenase / lactate and malic dehydrogenase / malate enzyme reactions were analyzed to obtain activation free energy changes of -329, -195 and -221 cal/mole, respectively, for rate increases associated with time-specific irradiation of the crystalline substrates prior to ...
arxiv  

Arginine metabolism is a biomarker of red blood cell and human aging

Aging Cell, Volume 24, Issue 2, February 2025.
Reisz et al. examined age‐related changes in erythrocyte metabolism using 15,700 specimens from 13,757 individuals across four cohorts, including healthy donors and sickle cell disease patients. The study identifies alterations in arginine metabolism associated with chronological age, linking them to erythrocyte function, vesiculation, and post ...
Julie A. Reisz, Eric J. Earley, Travis Nemkov, Alicia Key, Daniel Stephenson, Gregory R. Keele, Monika Dzieciatkowska, Steven L. Spitalnik, Eldad A. Hod, Steven Kleinman, Nareg H. Roubinian, Mark T. Gladwin, Kirk C. Hansen, Philip J. Norris, Michael P. Busch, James C. Zimring, Gary A. Churchill, Grier P. Page, Angelo D'Alessandro   +18 more
wiley   +1 more source

Evolution: The Case of the Glyceraldehyde-3-Phosphate Dehydrogenase Gene [PDF]

arXiv, 2000
The enzyme Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) catalyses the decomposition of glucose. The gene that produces the GAPDH is therefore present in a wide class of organisms. We show that for this gene the average value of the fluctuations in nucleotide distribution in the codons, normalized to strand bias, provides a reasonable measure of how
arxiv  

Increased transforming growth factor-beta1circulating levels and production in human monocytes after 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase inhibition with pravastatin [PDF]

, 2002
ObjectivesWe sought to determine whether inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase with pravastatin affects transforming growth factor-beta1(TGF-beta1) circulating levels and its production in the monocytes of ...
Baccante, Giovanna, Cuccurullo, Franco, Di Febbo, Concetta, Di Nisio, Marcello, Porreca, Ettore   +4 more
core   +1 more source

Hypoglycemic and hypolipidemic bioactive compounds from edible traditional Chinese medicines and their action of mechanisms explored by multitarget affinity ultrafiltration with liquid chromatography–mass spectrometry

Food Frontiers, Volume 6, Issue 1, Page 65-85, January 2025.
• Overviewed edible TCMs for their hypoglycemic and hypolipidemic potentials • Reviewed screening strategies for bioactive compounds in edible TCMs by UF/LC‐MS • Updated molecular mechanisms of hypoglycemic and hypolipidemic compounds in edible TCMs • Prospected future trends and challenges in more efficient multi‐target based UF/LC‐MS Abstract Edible ...
Xiaowen Hua, Mengjia Xu, Ming Yang, Yingying Zhang, Jianke Ma, Li Cheng, Chu Chu, Zimiao Wu, Mingquan Guo   +8 more
wiley   +1 more source