Results 51 to 60 of about 954 (132)

Connecting the Dots: Bridging Microsamples and Conventional Blood Matrices in Metabolic Biomarker Analysis

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT Bridging the gap between microsampling techniques and standard blood matrices presents a groundbreaking opportunity in metabolic biomarker analysis, offering minimally invasive, patient‐centric alternatives to traditional venipuncture. This review presents the current knowledge obtained from the comparison of biomarkers analysis in liquid ...
Marlene Thaitumu, Vasiliki Gkanali, Georgios Theodoridis, Helen Gika   +3 more
wiley   +1 more source

Depot-Specific Adipose Tissue Metabolite Profiles and Corresponding Changes Following Aerobic Exercise [PDF]

, 2018
Objectives: Total, visceral, and abdominal subcutaneous adipose tissue (AT) depots have distinct associations with cardiometabolic health; however, the metabolite profiles that characterize each AT depot and its reduction following exercise are poorly ...
Andre Tchernof, Andre Tchernof, Andre Tchernof, Andrea M. Brennan, Robert E. Gerszten, Robert Ross, Theresa E. Cowan   +6 more
core   +1 more source

Ketogenic Diet Modulates Gut Microbiota–Brain Metabolite Axis in a Sex‐ and Genotype‐Specific Manner in APOE4 Mice

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
(Top) The apolipoprotein ε4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD), whereas the ε3 (APOE3) allele confers neutral risk. APOE4 carriers, especially females, exhibit early neurometabolic deficits and gut microbiome dysbiosis. A ketogenic diet (KD) may mitigate these deficits.
Kira Ivanich, Andrew Yackzan, Abeoseh Flemister, Ya‐Hsuan Chang, Xin Xing, Anna Chen, Lucille M. Yanckello, McKenna Sun, Chetan Aware, Maalavika Govindarajan, Skyler Kramer, Aaron Ericsson, Ai‐Ling Lin   +12 more
wiley   +1 more source

Whole-Genome Sequencing analysis of Human Metabolome in Multi-Ethnic Populations [PDF]

, 2023
Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome sequencing association analysis of both common and
Alkis, Taryn, Brown, Michael R, Chen, Han, Feofanova, Elena V, Gerszten, Robert E, Grieser, Charles, Kelly, Rachel S, Larson, Martin G, Lasky-Su, Jessica, Lemaitre, Rozenn N, Li, Xihao, Li, Zilin, Manuel, Astrid M, Mendez, Kevin M, Morrison, Alanna C, Qi, Qibin, Tahir, Usman A, Wong, Kari E, Yu, Bing, Zhao, Zhongming   +19 more
core   +1 more source

Erchen Decoction Offers Health Benefits in Regulating Obesity: Component Analysis, Network Pharmacology, and Experiment Verification

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This study explored the potential of Erchen Decoction (ECT) in treating simple obesity by integrating network pharmacology, molecular docking, and animal experiments. ECT was found to regulate lipid metabolism, oxidative stress, and immune responses, with key compounds exhibiting strong binding to oxidative stress and immune markers. Animal experiments
Longfei Zhang, Xiaoxiao Liu, Mingze Xu, Yang Liu, Jiahao Yang, Wenqiong Wang, Hengxian Qu, Tianzhu Guan, Dawei Chen, Ruixia Gu   +9 more
wiley   +1 more source

Non-targeted urine metabolomics and associations with prevalent and incident type 2 diabetes [PDF]

, 2020
Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D.
Berne, Christian, Broeckling, Corey D., Fall, Tove, Ganna, Andrea, Ingelsson, Erik, Lind, Lars, Nowak, Christoph, Prenni, Jessica E., Salihovic, Samira, Sundström, Johan, Ärnlöv, Johan   +10 more
core   +1 more source

Gut Microbiota Composition and Modulation in Developmental and Epileptic Encephalopathies

European Journal of Neuroscience, Volume 62, Issue 4, August 2025.
Clinical studies link gut microbiota (GM) composition to adrenocorticotropic hormone (ACTH) treatment response. In infantile epileptic spasms syndrome (IESS) mouse models, GM modulation via antibiotics, ketogenic diet (KD), fecal transplantation, or probiotics reduced epileptic spasms, while in Dravet syndrome (DS) models, the KD showed no anti‐seizure
Takwa Ammar, Fatma Abdelhedi, Leila Ammar keskes, Chahnez Charfi Triki   +3 more
wiley   +1 more source

Systemic delivery of AAV-GCDH ameliorates HLD-induced phenotype in a glutaric aciduria type I mouse model

Molecular Therapy: Methods & Clinical Development
Glutaric aciduria type 1 (GA1) is a rare inherited metabolic disorder caused by a deficiency of glutaryl-coenzyme A dehydrogenase (GCDH), with accumulation of neurotoxic metabolites, resulting in a complex movement disorder, irreversible brain damage ...
Anna Mateu-Bosch, Eulàlia Segur-Bailach, Emma Muñoz-Moreno, María José Barallobre, Maria Lourdes Arbonés, Sabrina Gea-Sorlí, Frederic Tort, Antonia Ribes, Judit García-Villoria, Cristina Fillat   +9 more
doaj   +1 more source

Does renal GCDH expression contribute to the explanation of the two excretor types in glutaric aciduria type I? [PDF]

, 2015
This Master Thesis was carried out at the University of Lausanne and is part of the master's curriculum in the School of Medicine(1). All manipulations have been done at the laboratory of the "Centre des Maladies Moléculaires" (CMM) which is part of the "
PARATA, G.
core  

Ethylene Glycol Monomethyl Ether–Induced Toxicity Is Mediated through the Inhibition of Flavoprotein Dehydrogenase Enzyme Family [PDF]

Ethylene glycol monomethyl ether (EGME) is a widely used industrial solvent known to cause adverse effects to human and other mammals. Organs with high metabolism and rapid cell division, such as testes, are especially sensitive to its actions.
Adam, Klaus-Peter, Ando, Yosuke, Guo, Lining, Iwabuchi, Haruo, Kiyosawa, Naoki, Manabe, Sunao, Milburn, Michael V., Okazaki, Osamu, Ryals, John A., Saitoh, Wataru, Sanbuissho, Atsushi, Takei, Makoto, Tanimoto, Tomoe, Weiel, James E., Yamoto, Takashi   +14 more
core   +2 more sources